Zinc in PDB 2li8: The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna

The binding sites of Zinc atom in the The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna (pdb code 2li8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna, PDB code: 2li8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn187 b:0.0 occ:1.00 NE2 A:HIS147 2.1 0.0 1.0 SG A:CYS142 2.1 0.0 1.0 SG A:CYS139 2.1 0.0 1.0 SG A:CYS152 2.1 0.0 1.0 HB3 A:CYS142 2.6 0.0 1.0 CB A:CYS142 2.9 0.0 1.0 CD2 A:HIS147 3.0 0.0 1.0 H A:CYS142 3.0 0.0 1.0 HB2 A:CYS152 3.1 0.0 1.0 CB A:CYS139 3.1 0.0 1.0 HB3 A:CYS139 3.1 0.0 1.0 HD2 A:HIS147 3.1 0.0 1.0 CB A:CYS152 3.2 0.0 1.0 CE1 A:HIS147 3.2 0.0 1.0 HB2 A:CYS139 3.2 0.0 1.0 HA A:CYS152 3.3 0.0 1.0 H A:GLY144 3.4 0.0 1.0 HE1 A:HIS147 3.5 0.0 1.0 H A:GLY143 3.5 0.0 1.0 HB3 A:ASN141 3.5 0.0 1.0 N A:CYS142 3.6 0.0 1.0 CA A:CYS142 3.8 0.0 1.0 HB2 A:CYS142 3.8 0.0 1.0 CA A:CYS152 3.8 0.0 1.0 HD21 A:ASN141 4.0 0.0 1.0 HA A:ALA149 4.0 0.0 1.0 HD11 A:LEU154 4.1 0.0 1.0 HB3 A:CYS152 4.1 0.0 1.0 H A:LYS153 4.2 0.0 1.0 H A:ASN141 4.2 0.0 1.0 CG A:HIS147 4.2 0.0 1.0 N A:GLY143 4.2 0.0 1.0 ND1 A:HIS147 4.3 0.0 1.0 HE2 A:LYS153 4.3 0.0 1.0 N A:GLY144 4.4 0.0 1.0 HG A:LEU154 4.4 0.0 1.0 HA3 A:GLY144 4.5 0.0 1.0 C A:CYS142 4.5 0.0 1.0 CA A:CYS139 4.5 0.0 1.0 HD23 A:LEU154 4.5 0.0 1.0 C A:ASN141 4.6 0.0 1.0 CB A:ASN141 4.6 0.0 1.0 O A:HIS148 4.6 0.0 1.0 HA A:CYS142 4.7 0.0 1.0 N A:CYS152 4.7 0.0 1.0 H A:CYS152 4.8 0.0 1.0 CD1 A:LEU154 4.8 0.0 1.0 HD12 A:LEU154 4.9 0.0 1.0 ND2 A:ASN141 4.9 0.0 1.0 C A:CYS139 4.9 0.0 1.0 HA A:CYS139 4.9 0.0 1.0 O A:CYS139 4.9 0.0 1.0 N A:LYS153 4.9 0.0 1.0 CA A:GLY144 5.0 0.0 1.0 C A:HIS148 5.0 0.0 1.0 CA A:ASN141 5.0 0.0 1.0 C A:CYS152 5.0 0.0 1.0 N A:ASN141 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Solution Structure of the LIN28-Znf Domains Bound to Aggagau of Pre-Let-7 Mirna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn188 b:0.0 occ:1.00 SG A:CYS164 2.1 0.0 1.0 SG A:CYS161 2.1 0.0 1.0 NE2 A:HIS169 2.1 0.0 1.0 SG A:CYS174 2.1 0.0 1.0 HB2 A:CYS174 2.9 0.0 1.0 HD2 A:PRO175 3.0 0.0 1.0 HA A:CYS174 3.0 0.0 1.0 CD2 A:HIS169 3.0 0.0 1.0 HB3 A:CYS164 3.0 0.0 1.0 HB3 A:PHE163 3.0 0.0 1.0 H A:CYS164 3.0 0.0 1.0 CB A:CYS174 3.0 0.0 1.0 HD2 A:HIS169 3.1 0.0 1.0 CB A:CYS161 3.1 0.0 1.0 CB A:CYS164 3.2 0.0 1.0 HB3 A:CYS161 3.2 0.0 1.0 HB2 A:CYS161 3.3 0.0 1.0 CE1 A:HIS169 3.3 0.0 1.0 N A:CYS164 3.5 0.0 1.0 CA A:CYS174 3.6 0.0 1.0 HB2 A:SER166 3.6 0.0 1.0 HE1 A:HIS169 3.6 0.0 1.0 H A:SER166 3.9 0.0 1.0 HA A:VAL171 3.9 0.0 1.0 CA A:CYS164 3.9 0.0 1.0 HG A:SER166 4.0 0.0 1.0 CD A:PRO175 4.0 0.0 1.0 HB3 A:CYS174 4.0 0.0 1.0 HB2 A:CYS164 4.1 0.0 1.0 CB A:PHE163 4.1 0.0 1.0 H A:PHE163 4.2 0.0 1.0 HG A:LEU176 4.2 0.0 1.0 CG A:HIS169 4.2 0.0 1.0 HD1 A:PHE163 4.3 0.0 1.0 HD3 A:PRO175 4.3 0.0 1.0 C A:PHE163 4.3 0.0 1.0 ND1 A:HIS169 4.3 0.0 1.0 H A:LEU176 4.4 0.0 1.0 H A:GLN165 4.5 0.0 1.0 HD13 A:LEU176 4.5 0.0 1.0 CA A:CYS161 4.5 0.0 1.0 O A:MET170 4.5 0.0 1.0 HB2 A:PHE163 4.6 0.0 1.0 CB A:SER166 4.6 0.0 1.0 N A:CYS174 4.6 0.0 1.0 C A:CYS174 4.6 0.0 1.0 C A:CYS164 4.6 0.0 1.0 CA A:PHE163 4.7 0.0 1.0 N A:PRO175 4.7 0.0 1.0 OG A:SER166 4.7 0.0 1.0 N A:GLN165 4.8 0.0 1.0 N A:SER166 4.8 0.0 1.0 C A:MET170 4.8 0.0 1.0 N A:PHE163 4.8 0.0 1.0 H A:CYS174 4.8 0.0 1.0 HA A:CYS164 4.9 0.0 1.0 CA A:VAL171 4.9 0.0 1.0 HA A:CYS161 4.9 0.0 1.0 HG2 A:PRO175 4.9 0.0 1.0 HB2 A:LEU176 4.9 0.0 1.0 N A:VAL171 4.9 0.0 1.0 CD1 A:PHE163 5.0 0.0 1.0 CG A:PHE163 5.0 0.0 1.0

F.E.Loughlin, L.F.Gebert, H.Towbin, A.Brunschweiger, J.Hall, F.H.Allain. Structural Basis of Pre-Let-7 Mirna Recognition By the Zinc Knuckles of Pluripotency Factor LIN28. Nat.Struct.Mol.Biol. V. 19 84 2011.
ISSN: ISSN 1545-9993
PubMed: 22157959
DOI: 10.1038/NSMB.2202