Zinc in PDB 2lbm: Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3

All present enzymatic activity of Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3:
3.6.4.12;

The binding sites of Zinc atom in the Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3 (pdb code 2lbm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3, PDB code: 2lbm:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:0.0 occ:1.00 SG A:CYS171 2.3 0.0 1.0 SG A:CYS200 2.3 0.0 1.0 SG A:CYS174 2.3 0.0 1.0 SG A:CYS197 2.3 0.0 1.0 H A:CYS197 2.8 0.0 1.0 HB2 A:CYS174 3.3 0.0 1.0 CB A:CYS171 3.4 0.0 1.0 HB2 A:CYS200 3.4 0.0 1.0 HB2 A:CYS171 3.4 0.0 1.0 CB A:CYS174 3.5 0.0 1.0 CB A:CYS200 3.5 0.0 1.0 HB3 A:CYS171 3.5 0.0 1.0 HB3 A:CYS197 3.5 0.0 1.0 CB A:CYS197 3.5 0.0 1.0 H A:CYS174 3.6 0.0 1.0 N A:CYS197 3.6 0.0 1.0 HB1 A:ALA173 3.6 0.0 1.0 HB A:ILE196 3.7 0.0 1.0 H A:CYS200 3.8 0.0 1.0 N A:CYS174 4.0 0.0 1.0 N A:CYS200 4.1 0.0 1.0 CA A:CYS197 4.1 0.0 1.0 HB3 A:CYS174 4.2 0.0 1.0 CA A:CYS200 4.3 0.0 1.0 HB3 A:CYS200 4.3 0.0 1.0 H A:ALA173 4.4 0.0 1.0 CA A:CYS174 4.4 0.0 1.0 HA A:CYS200 4.4 0.0 1.0 HB2 A:CYS197 4.4 0.0 1.0 HB2 A:ASN199 4.4 0.0 1.0 HA A:ILE196 4.4 0.0 1.0 O A:CYS197 4.5 0.0 1.0 CB A:ALA173 4.5 0.0 1.0 C A:ILE196 4.6 0.0 1.0 HB2 A:ALA173 4.6 0.0 1.0 CB A:ILE196 4.6 0.0 1.0 C A:CYS197 4.7 0.0 1.0 C A:ALA173 4.7 0.0 1.0 CA A:CYS171 4.8 0.0 1.0 CA A:ILE196 4.8 0.0 1.0 HB3 A:ASN199 4.8 0.0 1.0 HA A:CYS174 4.8 0.0 1.0 N A:ALA173 4.9 0.0 1.0 HA A:CYS171 5.0 0.0 1.0 CA A:ALA173 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2 b:0.0 occ:1.00 SG A:CYS220 2.3 0.0 1.0 SG A:CYS243 2.3 0.0 1.0 SG A:CYS240 2.3 0.0 1.0 SG A:CYS223 2.3 0.0 1.0 H A:CYS223 2.9 0.0 1.0 HB2 A:CYS243 3.1 0.0 1.0 CB A:CYS220 3.3 0.0 1.0 CB A:CYS243 3.3 0.0 1.0 HB3 A:CYS220 3.3 0.0 1.0 HB2 A:CYS220 3.4 0.0 1.0 HB3 A:CYS223 3.5 0.0 1.0 CB A:CYS223 3.5 0.0 1.0 HB3 A:CYS240 3.6 0.0 1.0 CB A:CYS240 3.6 0.0 1.0 H A:CYS240 3.7 0.0 1.0 N A:CYS223 3.7 0.0 1.0 HB3 A:TRP222 3.7 0.0 1.0 H A:CYS243 3.9 0.0 1.0 HB3 A:CYS243 4.1 0.0 1.0 HD1 A:PHE239 4.1 0.0 1.0 N A:CYS240 4.2 0.0 1.0 CA A:CYS223 4.2 0.0 1.0 N A:CYS243 4.3 0.0 1.0 CA A:CYS243 4.3 0.0 1.0 HB3 A:LYS242 4.3 0.0 1.0 HB2 A:CYS223 4.4 0.0 1.0 HB2 A:CYS240 4.4 0.0 1.0 HB2 A:TRP222 4.4 0.0 1.0 CA A:CYS240 4.4 0.0 1.0 H A:TRP222 4.4 0.0 1.0 HB2 A:GLU225 4.4 0.0 1.0 CB A:TRP222 4.5 0.0 1.0 H A:ALA224 4.5 0.0 1.0 HA A:CYS243 4.6 0.0 1.0 O A:CYS240 4.6 0.0 1.0 CA A:CYS220 4.7 0.0 1.0 C A:CYS223 4.8 0.0 1.0 C A:TRP222 4.8 0.0 1.0 N A:ALA224 4.9 0.0 1.0 C A:CYS240 4.9 0.0 1.0 N A:TRP222 4.9 0.0 1.0 HA A:CYS220 4.9 0.0 1.0 HA A:PHE239 4.9 0.0 1.0

Zinc binding site 3 out of 3 in the Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of the Add Domain of Atrx Complexed with Histone Tail H3 1-15 K9ME3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn3 b:0.0 occ:1.00 SG A:CYS235 2.3 0.0 1.0 SG A:CYS265 2.3 0.0 1.0 SG A:CYS232 2.3 0.0 1.0 SG A:CYS268 2.3 0.0 1.0 H A:CYS235 2.8 0.0 1.0 H A:CYS268 3.1 0.0 1.0 HB3 A:CYS235 3.3 0.0 1.0 CB A:CYS232 3.3 0.0 1.0 CB A:CYS235 3.4 0.0 1.0 HB2 A:CYS232 3.4 0.0 1.0 HB2 A:PHE234 3.4 0.0 1.0 HB3 A:CYS232 3.4 0.0 1.0 HB2 A:CYS268 3.5 0.0 1.0 HB3 A:CYS265 3.6 0.0 1.0 CB A:CYS268 3.6 0.0 1.0 CB A:CYS265 3.6 0.0 1.0 HB A:ILE267 3.7 0.0 1.0 H A:CYS265 3.7 0.0 1.0 N A:CYS235 3.7 0.0 1.0 HD1 A:TYR264 3.8 0.0 1.0 N A:CYS268 4.0 0.0 1.0 N A:CYS265 4.1 0.0 1.0 CA A:CYS235 4.2 0.0 1.0 HB2 A:CYS235 4.3 0.0 1.0 HA A:TYR264 4.3 0.0 1.0 H A:PHE234 4.3 0.0 1.0 CA A:CYS268 4.4 0.0 1.0 HB3 A:CYS268 4.4 0.0 1.0 HB2 A:CYS265 4.4 0.0 1.0 HB2 A:ASN237 4.4 0.0 1.0 CB A:PHE234 4.4 0.0 1.0 H A:ILE267 4.4 0.0 1.0 CA A:CYS265 4.5 0.0 1.0 HB3 A:ASN237 4.5 0.0 1.0 HG12 A:ILE267 4.5 0.0 1.0 HD2 A:PHE234 4.5 0.0 1.0 HB3 A:PHE234 4.6 0.0 1.0 CB A:ILE267 4.6 0.0 1.0 HA A:CYS268 4.7 0.0 1.0 C A:TYR264 4.7 0.0 1.0 CD1 A:TYR264 4.7 0.0 1.0 CA A:CYS232 4.7 0.0 1.0 C A:PHE234 4.8 0.0 1.0 C A:CYS235 4.8 0.0 1.0 N A:PHE234 4.9 0.0 1.0 CB A:ASN237 5.0 0.0 1.0 CA A:TYR264 5.0 0.0 1.0 CG1 A:ILE267 5.0 0.0 1.0 HG13 A:ILE267 5.0 0.0 1.0

S.Eustermann, J.Yang, M.J.Law, R.Amos, L.M.Chapman, C.Jelinska, D.Garrick, D.Clynes, R.J.Gibbons, D.Rhodes, D.R.Higgs, D.Neuhaus. Combinatorial Readout of Histone H3 Modifications Specifies Localization of Atrx to Heterochromatin Nat.Struct.Mol.Biol. 2011.
ISSN: ESSN 1545-9985
PubMed: 21666677
DOI: 10.1038/NSMB.2070