Zinc in PDB 2i3v: Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant

The structure of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant, PDB code: 2i3v was solved by N.Armstrong, J.Jasti, M.Beich-Frandsen, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	63.191, 106.291, 192.817, 90.00, 90.00, 90.00
R / Rfree (%)	23.7 / 28.1

The binding sites of Zinc atom in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant (pdb code 2i3v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 7 binding sites of Zinc where determined in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant, PDB code: 2i3v:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7;

Zinc binding site 1 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:69.9 occ:1.00 OE1 A:GLU42 2.4 44.7 1.0 CE1 A:HIS46 2.5 58.2 1.0 NZ A:LYS45 2.9 57.2 1.0 NE2 A:HIS46 3.0 58.5 1.0 O A:HOH438 3.2 61.5 1.0 CD A:GLU42 3.2 41.9 1.0 OE2 A:GLU42 3.4 48.9 1.0 ND1 A:HIS46 3.6 58.6 1.0 CE A:LYS45 3.7 54.5 1.0 CD A:LYS45 4.2 50.1 1.0 CD2 A:HIS46 4.2 58.3 1.0 CD2 A:LEU241 4.3 38.5 1.0 CG A:HIS46 4.5 54.7 1.0 CG A:GLU42 4.6 40.6 1.0 CD2 A:LEU246 4.7 56.6 1.0 CB A:GLU42 4.9 38.8 1.0

Zinc binding site 2 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:91.7 occ:1.00 NE2 A:HIS23 2.3 59.4 1.0 CE1 A:HIS23 3.2 59.9 1.0 CD2 A:HIS23 3.4 59.9 1.0 OE2 A:GLU24 3.4 83.8 1.0 ND1 A:HIS23 4.4 61.4 1.0 CG A:HIS23 4.5 61.8 1.0 CD A:GLU24 4.6 81.7 1.0

Zinc binding site 3 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn303 b:77.4 occ:1.00 OE1 B:GLU166 2.5 71.2 1.0 OE2 B:GLU166 2.7 67.7 1.0 CD B:GLU166 2.9 69.1 1.0 CG B:GLU166 4.3 65.2 1.0

Zinc binding site 4 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn304 b:93.0 occ:1.00 CE1 B:HIS23 2.5 83.6 1.0 NE2 B:HIS23 3.1 83.2 1.0 ND1 B:HIS23 3.3 83.4 1.0 CD2 B:HIS23 4.1 82.9 1.0 CG B:HIS23 4.2 82.3 1.0

Zinc binding site 5 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn305 b:80.2 occ:1.00 OE1 B:GLU42 2.3 70.4 1.0 OE2 D:GLU166 2.3 42.9 1.0 CG D:GLU166 2.9 50.0 1.0 CD D:GLU166 3.0 53.9 1.0 CE1 B:HIS46 3.0 87.0 1.0 CD B:GLU42 3.3 67.5 1.0 OE2 B:GLU42 3.7 65.5 1.0 NE2 B:HIS46 3.7 87.7 1.0 ND1 B:HIS46 4.0 86.8 1.0 CB D:GLU166 4.1 49.5 1.0 OE1 D:GLU166 4.2 52.9 1.0 O D:ALA165 4.5 49.3 1.0 CG B:GLU42 4.5 66.5 1.0 CB B:GLU42 4.7 64.6 1.0 CA D:GLU166 4.8 49.1 1.0 CD2 B:LEU241 4.9 56.9 1.0 O D:HOH416 4.9 49.0 1.0 CD2 B:HIS46 5.0 86.2 1.0 CA B:GLU42 5.0 64.2 1.0

Zinc binding site 6 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn306 b:62.6 occ:1.00 OD1 C:ASP65 2.4 56.8 1.0 OD2 C:ASP65 2.5 55.7 1.0 OD2 C:ASP67 2.6 53.1 1.0 CG C:ASP65 2.7 57.3 1.0 CG C:ASP67 3.6 56.6 1.0 CB C:ASP67 3.9 57.5 1.0 CB C:ASP65 4.2 57.7 1.0 N C:ASP67 4.3 59.9 1.0 OD1 C:ASP67 4.7 58.6 1.0 CA C:ASP67 4.7 59.7 1.0 CA C:ASP65 4.8 56.3 1.0 N C:ALA66 4.9 57.5 1.0 C C:ASP65 4.9 56.8 1.0

Zinc binding site 7 out of 7 in the Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor: Structure of G725C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn307 b:90.6 occ:1.00 OE2 D:GLU98 2.5 74.8 1.0 O D:HOH429 2.8 70.6 1.0 OE1 D:GLU98 2.9 74.5 1.0 CD D:GLU98 3.0 73.9 1.0 O D:HOH447 4.1 72.7 1.0 CG D:GLU98 4.5 71.4 1.0

N.Armstrong, J.Jasti, M.Beich-Frandsen, E.Gouaux. Measurement of Conformational Changes Accompanying Desensitization in An Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.) V. 127 85 2006.
ISSN: ISSN 0092-8674
PubMed: 17018279
DOI: 10.1016/J.CELL.2006.08.037