Zinc in PDB 2f7p: Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A

All present enzymatic activity of Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A, PDB code: 2f7p was solved by D.A.Kuntz, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.33 / 1.28
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.954, 109.874, 139.035, 90.00, 90.00, 90.00
R / Rfree (%)	16.6 / 18

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A (pdb code 2f7p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A, PDB code: 2f7p:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II Complex with Benzyl-Mannostatin A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn5001 b:5.9 occ:1.00 NE2 A:HIS471 2.1 4.6 1.0 OD2 A:ASP204 2.1 6.0 1.0 NE2 A:HIS90 2.1 5.7 1.0 O3 A:2SK5009 2.2 6.2 1.0 OD1 A:ASP92 2.2 6.5 1.0 O4 A:2SK5009 2.2 6.2 1.0 CD2 A:HIS90 3.1 6.2 1.0 CD2 A:HIS471 3.1 5.3 1.0 CE1 A:HIS471 3.1 4.9 1.0 C4 A:2SK5009 3.1 6.0 1.0 C3 A:2SK5009 3.1 6.0 1.0 CE1 A:HIS90 3.1 5.4 1.0 CG A:ASP92 3.1 6.1 1.0 CG A:ASP204 3.2 6.4 1.0 OD2 A:ASP92 3.5 7.5 1.0 CB A:ASP204 3.6 6.3 1.0 N5 A:2SK5009 3.9 7.6 1.0 C5 A:2SK5009 4.0 7.5 1.0 OD2 A:ASP472 4.1 5.9 1.0 C1 A:2SK5009 4.1 6.3 1.0 ND1 A:HIS471 4.2 5.2 1.0 CG A:HIS90 4.2 4.8 1.0 C2 A:2SK5009 4.2 6.1 1.0 CG A:HIS471 4.2 4.3 1.0 ND1 A:HIS90 4.2 6.0 1.0 OD1 A:ASP204 4.3 6.8 1.0 CE1 A:HIS470 4.5 3.8 1.0 OH A:TYR269 4.5 9.2 1.0 CB A:ASP92 4.5 6.2 1.0 O A:HOH5918 4.6 9.3 1.0 O2 A:2SK5009 4.9 6.8 1.0

S.P.Kawatkar, D.A.Kuntz, R.J.Woods, D.R.Rose, G.J.Boons. Structural Basis of the Inhibition of Golgi Alpha-Mannosidase II By Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions. J.Am.Chem.Soc. V. 128 8310 2006.
ISSN: ISSN 0002-7863
PubMed: 16787095
DOI: 10.1021/JA061216P