Zinc in PDB 2cjs: Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules

The structure of Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules, PDB code: 2cjs was solved by J.Lu, M.Machius, I.Dulubova, H.Dai, T.C.Sudhof, D.R.Tomchick, J.Rizo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.78
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.248, 93.534, 113.128, 90.00, 90.00, 90.00
R / Rfree (%)	17.5 / 21.9

The binding sites of Zinc atom in the Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules (pdb code 2cjs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules, PDB code: 2cjs:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:19.1 occ:1.00 SG C:CYS119 2.3 21.8 1.0 SG C:CYS95 2.4 20.5 1.0 SG C:CYS92 2.4 20.9 1.0 SG C:CYS116 2.4 21.7 1.0 CB C:CYS92 3.1 20.6 1.0 CB C:CYS119 3.2 20.8 1.0 CB C:CYS95 3.2 21.7 1.0 CB C:CYS116 3.5 21.5 1.0 N C:CYS95 3.7 21.5 1.0 N C:CYS116 3.9 20.9 1.0 CA C:CYS95 4.1 21.4 1.0 OG1 C:THR98 4.1 19.5 1.0 CA C:CYS116 4.2 21.8 1.0 CA C:CYS119 4.5 20.9 1.0 CB C:THR98 4.5 18.9 1.0 N C:CYS119 4.5 21.5 1.0 CA C:CYS92 4.6 20.9 1.0 CB C:ILE94 4.6 21.8 1.0 O C:HOH2043 4.6 39.5 1.0 C C:CYS116 4.6 21.9 1.0 O C:CYS116 4.6 22.0 1.0 CB C:ARG118 4.8 22.6 1.0 C C:ILE94 4.8 22.0 1.0 C C:CYS95 4.9 21.1 1.0 N C:HIS96 5.0 21.2 1.0

Zinc binding site 2 out of 2 in the Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis For A MUNC13-1 Homodimer - MUNC13-1 - Rim Heterodimer Switch: C2-Domains As Versatile Protein-Protein Interaction Modules within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn202 b:19.0 occ:1.00 SG C:CYS137 2.3 19.3 1.0 SG C:CYS111 2.3 20.5 1.0 SG C:CYS108 2.4 20.8 1.0 SG C:CYS134 2.4 20.5 1.0 CB C:CYS108 3.1 19.3 1.0 CB C:CYS137 3.2 20.9 1.0 CB C:CYS111 3.3 18.1 1.0 CB C:CYS134 3.5 20.1 1.0 O C:HOH2040 3.8 16.5 0.5 N C:CYS111 3.8 19.6 1.0 N C:CYS134 3.9 20.8 1.0 N C:CYS137 4.1 20.0 1.0 CA C:CYS111 4.1 19.1 1.0 CA C:CYS134 4.2 20.2 1.0 CA C:CYS137 4.3 19.4 1.0 O C:CYS134 4.6 19.4 1.0 CA C:CYS108 4.6 20.2 1.0 C C:CYS134 4.7 21.6 1.0 CB C:TYR110 4.7 19.0 1.0 C C:CYS111 4.9 20.0 1.0 N C:GLN112 4.9 17.8 1.0 C C:TYR110 4.9 19.2 1.0

J.Lu, M.Machius, I.Dulubova, H.Dai, T.C.Sudhof, D.R.Tomchick, J.Rizo. Structural Basis For A MUNC13-1 Homodimer to MUNC13-1/Rim Heterodimer Switch. Plos Biol. V. 4 E192 2006.
ISSN: ISSN 1544-9173
PubMed: 16732694
DOI: 10.1371/JOURNAL.PBIO.0040192