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Atomistry » Zinc » PDB 2aqs-2b83 » 2aw1 » |
Zinc in PDB 2aw1: Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor CelecoxibEnzymatic activity of Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib
All present enzymatic activity of Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib, PDB code: 2aw1
was solved by
A.Di Fiore,
C.Pedone,
K.D'ambrosio,
A.Scozzafava,
G.De Simone,
C.T.Supuran,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2aw1:
The structure of Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib
(pdb code 2aw1). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib, PDB code: 2aw1: Zinc binding site 1 out of 1 in 2aw1Go back to![]() ![]()
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II "Selective" Inhibitor Celecoxib
![]() Mono view ![]() Stereo pair view
Reference:
A.Di Fiore,
C.Pedone,
K.D'ambrosio,
A.Scozzafava,
G.De Simone,
C.T.Supuran.
Carbonic Anhydrase Inhibitors: Valdecoxib Binds to A Different Active Site Region of the Human Isoform II As Compared to the Structurally Related Cyclooxygenase II Bioorg.Med.Chem.Lett. V. 16 437 2006.
Page generated: Wed Oct 16 21:50:17 2024
ISSN: ISSN 0960-894X PubMed: 16290146 DOI: 10.1016/J.BMCL.2005.09.040 |
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