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Zinc in PDB 1zkl: Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

Enzymatic activity of Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

All present enzymatic activity of Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases:
3.1.4.17;

Protein crystallography data

The structure of Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases, PDB code: 1zkl was solved by H.Wang, Y.Liu, Y.Chen, H.Robinson, H.Ke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.50 / 1.67
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 115.751, 115.751, 64.290, 90.00, 90.00, 120.00
R / Rfree (%) 19.4 / 20.7

Other elements in 1zkl:

The structure of Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases (pdb code 1zkl). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases, PDB code: 1zkl:

Zinc binding site 1 out of 1 in 1zkl

Go back to Zinc Binding Sites List in 1zkl
Zinc binding site 1 out of 1 in the Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Multiple Determinants For Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:15.4
occ:1.00
 OD2 A:ASP253 2.0 12.8 1.0
OD1 A:ASP362 2.1 14.2 1.0
NE2 A:HIS252 2.1 11.5 1.0
NE2 A:HIS216 2.1 12.8 1.0
O A:HOH509 2.2 15.1 1.0
O A:HOH504 2.3 14.9 1.0
CD2 A:HIS252 3.0 11.0 1.0
CG A:ASP362 3.1 14.8 1.0
CG A:ASP253 3.1 12.8 1.0
CD2 A:HIS216 3.1 12.8 1.0
CE1 A:HIS216 3.1 12.9 1.0
CE1 A:HIS252 3.2 11.2 1.0
OD2 A:ASP362 3.4 15.9 1.0
OD1 A:ASP253 3.6 11.7 1.0
MG A:MG502 3.8 13.7 1.0
CG A:HIS252 4.2 11.2 1.0
O A:HOH542 4.2 23.8 1.0
O A:HOH505 4.2 13.8 1.0
ND1 A:HIS216 4.2 13.1 1.0
ND1 A:HIS252 4.2 11.4 1.0
CG A:HIS216 4.2 12.9 1.0
CD2 A:HIS212 4.3 13.9 1.0
CB A:ASP253 4.3 11.6 1.0
NE2 A:HIS212 4.4 14.7 1.0
CB A:ASP362 4.4 13.9 1.0
CG2 A:VAL220 4.7 12.2 1.0
O A:ASP362 4.7 14.8 1.0
O A:HOH508 4.7 11.6 1.0
CA A:ASP362 4.9 13.7 1.0

Reference:

H.Wang, Y.Liu, Y.Chen, H.Robinson, H.Ke. Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7 J.Biol.Chem. V. 280 30949 2005.
ISSN: ISSN 0021-9258
PubMed: 15994308
DOI: 10.1074/JBC.M504398200
Page generated: Wed Oct 16 21:16:39 2024

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