Atomistry » Zinc » PDB 1zfp-1zsb » 1zfq
Atomistry »
  Zinc »
    PDB 1zfp-1zsb »
      1zfq »

Zinc in PDB 1zfq: Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor

Enzymatic activity of Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor

All present enzymatic activity of Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor, PDB code: 1zfq was solved by V.S.Honndorf, A.Heine, G.Klebe, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.55
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.390, 41.420, 72.230, 90.00, 104.54, 90.00
R / Rfree (%) 15.2 / 18.8

Other elements in 1zfq:

The structure of Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor (pdb code 1zfq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor, PDB code: 1zfq:

Zinc binding site 1 out of 1 in 1zfq

Go back to Zinc Binding Sites List in 1zfq
Zinc binding site 1 out of 1 in the Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn600

b:9.5
occ:1.00
 N14 A:ZEC300 2.0 7.6 1.0
NE2 A:HIS94 2.0 10.3 1.0
NE2 A:HIS96 2.1 9.7 1.0
ND1 A:HIS119 2.1 9.9 1.0
CD2 A:HIS94 2.9 11.1 1.0
CE1 A:HIS119 2.9 7.8 1.0
CE1 A:HIS94 3.0 8.5 1.0
S11 A:ZEC300 3.0 9.9 1.0
O13 A:ZEC300 3.0 9.2 1.0
CD2 A:HIS96 3.0 9.7 1.0
CG A:HIS119 3.1 9.1 1.0
CE1 A:HIS96 3.1 11.0 1.0
CB A:HIS119 3.6 7.8 1.0
OG1 A:THR199 3.9 9.6 1.0
OE1 A:GLU106 4.0 9.2 1.0
O12 A:ZEC300 4.1 10.5 1.0
CG A:HIS94 4.1 10.6 1.0
ND1 A:HIS94 4.1 9.6 1.0
NE2 A:HIS119 4.1 9.5 1.0
CD2 A:HIS119 4.2 8.1 1.0
C9 A:ZEC300 4.2 11.8 1.0
ND1 A:HIS96 4.2 11.6 1.0
CG A:HIS96 4.2 8.4 1.0
C1 A:GOL900 4.4 15.2 1.0
N10 A:ZEC300 4.9 10.8 1.0
CD A:GLU106 5.0 12.9 1.0

Reference:

V.S.Honndorf, A.Heine, G.Klebe, C.T.Supuran. Carbonic Anhydrase II in Complex with Ethoxzolamidphenole As Sulfonamide Inhibitor To Be Published.
Page generated: Wed Oct 16 21:14:24 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy