Zinc in PDB 1uvq: Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide

The structure of Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide, PDB code: 1uvq was solved by C.Siebold, B.E.Hansen, J.R.Wyer, K.Harlos, R.E.Esnouf, A.Svejgaard, J.I.Bell, J.L.Strominger, E.Y.Jones, L.Fugger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.31 / 1.8
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	102.078, 129.304, 40.619, 90.00, 90.00, 90.00
R / Rfree (%)	18.9 / 20.5

The binding sites of Zinc atom in the Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide (pdb code 1uvq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide, PDB code: 1uvq:

Zinc binding site 1 out of 1 in the Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Hla-DQ0602 in Complex with A Hypocretin Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1192 b:9.6 occ:1.00 OD2 B:ASP76 2.1 10.3 1.0 NE2 B:HIS81 2.1 12.3 1.0 CD2 B:HIS81 3.0 10.7 1.0 CG B:ASP76 3.1 8.5 1.0 CE1 B:HIS81 3.2 13.3 1.0 OD1 B:ASP76 3.5 11.3 1.0 O B:HOH2090 4.0 13.2 1.0 CG B:HIS81 4.2 11.0 1.0 ND1 B:HIS81 4.2 11.9 1.0 O B:HOH2097 4.4 27.9 1.0 CB B:ASP76 4.4 7.4 1.0 O B:ASP76 4.9 9.9 1.0 C B:ASP76 4.9 8.5 1.0

C.Siebold, B.E.Hansen, J.R.Wyer, K.Harlos, R.E.Esnouf, A.Svejgaard, J.I.Bell, J.L.Strominger, E.Y.Jones, L.Fugger. Crystal Structure of Hla-DQ0602 That Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy Proc.Natl.Acad.Sci.Usa V. 101 1999 2004.
ISSN: ISSN 0027-8424
PubMed: 14769912
DOI: 10.1073/PNAS.0308458100