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Zinc in PDB 1pjp: The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone

Enzymatic activity of The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone

All present enzymatic activity of The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone:
3.4.21.39;

Protein crystallography data

The structure of The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone, PDB code: 1pjp was solved by P.J.B.Pereira, Z.M.Wang, H.Rubin, R.Huber, W.Bode, N.M.Schechter, S.Strobl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.20
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 74.370, 74.370, 50.090, 90.00, 90.00, 90.00
R / Rfree (%) 18.4 / 23.7

Zinc Binding Sites:

The binding sites of Zinc atom in the The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone (pdb code 1pjp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone, PDB code: 1pjp:

Zinc binding site 1 out of 1 in 1pjp

Go back to Zinc Binding Sites List in 1pjp
Zinc binding site 1 out of 1 in the The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl- Ala-Ala-Pro-Phe-Chloromethylketone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1000

b:22.8
occ:1.00
 OE2 A:GLU84 1.9 22.6 1.0
NZ A:LYS109 2.4 24.6 1.0
CD A:GLU84 2.8 20.4 1.0
OE1 A:GLU84 3.0 22.2 1.0
CE A:LYS109 3.1 24.9 1.0
CD A:LYS109 3.5 24.6 1.0
O A:HOH1015 4.1 20.9 1.0
CG A:GLU84 4.2 18.8 1.0
CG2 A:ILE86 4.3 15.7 1.0
O A:HOH1140 4.5 60.3 1.0
CG A:LYS109 4.6 23.8 1.0

Reference:

P.J.Pereira, Z.M.Wang, H.Rubin, R.Huber, W.Bode, N.M.Schechter, S.Strobl. The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl-Ala-Ala-Pro-Phe-Chloromethylketone: Structural Explanation For Its Dipeptidyl Carboxypeptidase Specificity. J.Mol.Biol. V. 286 163 1999.
ISSN: ISSN 0022-2836
PubMed: 9931257
DOI: 10.1006/JMBI.1998.2462
Page generated: Wed Oct 16 17:50:49 2024

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