Zinc in PDB 1mzb: Ferric Uptake Regulator

The structure of Ferric Uptake Regulator, PDB code: 1mzb was solved by E.Pohl, M.L.Vasil, J.C.Haller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	12.00 / 1.80
Space group	I 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	63.300, 63.300, 180.100, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 25.4

The binding sites of Zinc atom in the Ferric Uptake Regulator (pdb code 1mzb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Ferric Uptake Regulator, PDB code: 1mzb:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Ferric Uptake Regulator


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Ferric Uptake Regulator within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:32.2 occ:1.00 NE2 A:HIS86 2.0 32.2 1.0 OE2 A:GLU107 2.0 32.3 1.0 NE2 A:HIS124 2.2 28.8 1.0 OD2 A:ASP88 2.2 30.6 1.0 O A:HOH1086 2.3 30.4 1.0 OD1 A:ASP88 2.4 37.8 1.0 CG A:ASP88 2.6 28.1 1.0 CE1 A:HIS86 2.8 47.4 1.0 CD A:GLU107 2.8 31.8 1.0 OE1 A:GLU107 3.0 32.1 1.0 CD2 A:HIS124 3.1 25.4 1.0 CD2 A:HIS86 3.1 45.2 1.0 CE1 A:HIS124 3.2 28.9 1.0 O A:HOH1047 3.8 39.7 1.0 ND1 A:HIS86 4.0 47.1 1.0 CB A:ASP88 4.1 27.9 1.0 CG A:HIS86 4.2 46.6 1.0 CG A:GLU107 4.2 30.1 1.0 CG A:HIS124 4.3 26.9 1.0 NE2 A:GLN110 4.3 30.3 1.0 ND1 A:HIS124 4.3 29.7 1.0 O A:HOH1006 4.6 34.1 1.0 OE1 A:GLN110 4.7 31.9 1.0 N A:ASP88 4.9 37.8 1.0 CD A:GLN110 4.9 31.6 1.0 CA A:ASP88 4.9 32.7 1.0

Zinc binding site 2 out of 4 in the Ferric Uptake Regulator


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Ferric Uptake Regulator within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:31.3 occ:1.00 NE2 A:HIS32 2.0 29.8 1.0 OE1 A:GLU80 2.0 42.5 1.0 NE2 A:HIS89 2.0 23.9 1.0 OE2 A:GLU100 2.2 48.5 1.0 CD2 A:HIS32 2.8 36.1 1.0 CD A:GLU80 2.8 40.6 1.0 OE2 A:GLU80 2.8 45.7 1.0 CD2 A:HIS89 3.0 25.1 1.0 CE1 A:HIS89 3.1 28.0 1.0 CD A:GLU100 3.1 50.7 1.0 CE1 A:HIS32 3.2 36.6 1.0 CG A:GLU100 3.3 44.4 1.0 CG A:HIS32 4.0 34.7 1.0 CG A:HIS89 4.1 25.9 1.0 ND1 A:HIS89 4.2 25.9 1.0 ND1 A:HIS32 4.2 36.2 1.0 CG A:GLU80 4.2 37.6 1.0 OE1 A:GLU100 4.3 52.2 1.0 CB A:GLU100 4.8 41.2 1.0 CB A:GLU80 4.8 33.0 1.0 CB A:HIS87 5.0 48.3 1.0 CZ A:PHE72 5.0 28.2 1.0

Zinc binding site 3 out of 4 in the Ferric Uptake Regulator


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Ferric Uptake Regulator within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn203 b:26.4 occ:1.00 OD2 A:ASP73 1.9 26.1 1.0 ND1 A:HIS76 2.1 31.2 1.0 CG A:ASP73 2.7 27.7 1.0 OD1 A:ASP73 2.9 27.1 1.0 CE1 A:HIS76 3.0 28.2 1.0 CG A:HIS76 3.2 29.2 1.0 CB A:HIS76 3.6 28.3 1.0 O A:HOH1004 3.9 29.6 1.0 N A:HIS76 3.9 25.8 1.0 NE2 A:HIS76 4.2 32.0 1.0 CB A:ASP73 4.2 27.8 1.0 CD2 A:HIS76 4.3 26.7 1.0 C A:GLY75 4.3 26.4 1.0 CA A:HIS76 4.3 24.4 1.0 CA A:GLY75 4.6 25.4 1.0 O A:GLY75 4.8 23.9 1.0 O A:HOH1002 4.8 26.1 1.0 N A:GLY75 4.8 27.2 1.0

Zinc binding site 4 out of 4 in the Ferric Uptake Regulator


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Ferric Uptake Regulator within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn204 b:24.6 occ:0.50 OE2 A:GLU105 2.0 46.3 1.0 O A:HOH1088 2.4 6.5 0.5 CD A:GLU105 2.7 42.4 1.0 CG A:GLU105 2.8 36.7 1.0 OE1 A:GLU105 3.9 45.4 1.0 O A:HOH1114 4.1 53.9 1.0 CB A:GLU105 4.4 30.4 1.0 O A:GLU105 4.5 30.6 1.0 CB A:ARG109 4.5 26.7 1.0 C A:GLU105 4.7 30.1 1.0 CG A:ARG109 4.8 28.5 1.0 CD A:ARG109 4.8 32.2 1.0

E.Pohl, J.C.Haller, A.Mijovilovich, W.Meyer-Klaucke, E.Garman, M.L.Vasil. Architecture of A Protein Central to Iron Homeostatis: Crystal Structure and Spectroscopic Analysis of the Ferric Uptake Regulator Mol.Microbiol. V. 47 903 2003.
ISSN: ISSN 0950-382X
PubMed: 12581348
DOI: 10.1046/J.1365-2958.2003.03337.X