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Zinc in PDB 1ghx: A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site

Enzymatic activity of A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site

All present enzymatic activity of A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site:
3.4.21.5;

Protein crystallography data

The structure of A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site, PDB code: 1ghx was solved by B.A.Katz, K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer, J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris, E.Verner, W.Young, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 7.00 / 1.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 72.300, 71.950, 72.960, 90.00, 101.54, 90.00
R / Rfree (%) 20.7 / 25.5

Other elements in 1ghx:

The structure of A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site (pdb code 1ghx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site, PDB code: 1ghx:

Zinc binding site 1 out of 1 in 1ghx

Go back to Zinc Binding Sites List in 1ghx
Zinc binding site 1 out of 1 in the A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Zn859

b:52.2
occ:1.00
 NE2 H:HIS119 2.1 22.1 1.0
OD2 L:ASP1A 2.3 59.6 1.0
NZ L:LYS9 2.5 31.8 0.5
HZ2 L:LYS9 2.5 32.9 0.5
O H:HOH856 2.7 38.9 1.0
CE1 H:HIS119 2.9 18.6 1.0
HE1 H:HIS119 3.0 18.4 1.0
HZ1 L:LYS9 3.1 32.6 0.5
CG L:ASP1A 3.1 58.6 1.0
CD2 H:HIS119 3.2 20.6 1.0
H1 H:HOH856 3.4 39.9 1.0
H2 H:HOH856 3.5 39.0 1.0
HD2 H:HIS119 3.6 21.3 1.0
CE L:LYS9 3.6 30.1 0.5
H2 H:HOH1206 3.6 62.3 1.0
OD1 L:ASP1A 3.6 60.3 1.0
HE2 L:LYS9 3.7 30.2 0.5
HE3 L:LYS9 3.8 30.3 0.5
HD2 H:PHE114 3.8 30.5 1.0
H2 L:HOH1195 3.9 63.9 1.0
ND1 H:HIS119 4.1 18.6 1.0
HB3 L:ASP1A 4.2 55.2 1.0
HG3 L:PRO5 4.2 14.6 1.0
CB L:ASP1A 4.3 54.9 1.0
CG H:HIS119 4.3 23.6 1.0
HE3 L:LYS9 4.3 30.3 0.4
O L:HOH1195 4.4 63.0 1.0
O H:HOH1206 4.4 62.3 1.0
H1 H:HOH1206 4.5 62.2 1.0
HB2 L:ASP1A 4.6 55.8 1.0
O L:HOH1211 4.6 61.9 1.0
H1 L:HOH1195 4.6 63.9 1.0
HB2 H:PHE114 4.7 34.2 1.0
CD2 H:PHE114 4.7 30.6 1.0
HD3 L:LYS9 4.9 27.9 0.5
CD L:LYS9 4.9 29.4 0.5
HB3 H:PHE114 4.9 33.7 1.0
HZ2 L:LYS9 4.9 32.6 0.4
HD1 H:HIS119 5.0 19.2 1.0

Reference:

B.A.Katz, K.Elrod, C.Luong, M.J.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer, J.Hataye, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris, E.Verner, W.Young. A Novel Serine Protease Inhibition Motif Involving A Multi-Centered Short Hydrogen Bonding Network at the Active Site. J.Mol.Biol. V. 307 1451 2001.
ISSN: ISSN 0022-2836
PubMed: 11292354
DOI: 10.1006/JMBI.2001.4516
Page generated: Sun Oct 13 01:31:20 2024

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