Zinc in PDB 1g7a: 1.2 A Structure of T3R3 Human Insulin at 100 K

The structure of 1.2 A Structure of T3R3 Human Insulin at 100 K, PDB code: 1g7a was solved by G.D.Smith, W.A.Pangborn, R.H.Blessing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.20 / 1.20
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	80.127, 80.127, 71.582, 90.00, 90.00, 120.00
R / Rfree (%)	16.9 / 19.3

The structure of 1.2 A Structure of T3R3 Human Insulin at 100 K also contains other interesting chemical elements:

Chlorine

(Cl)

7 atoms

The binding sites of Zinc atom in the 1.2 A Structure of T3R3 Human Insulin at 100 K (pdb code 1g7a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 7 binding sites of Zinc where determined in the 1.2 A Structure of T3R3 Human Insulin at 100 K, PDB code: 1g7a:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7;

Zinc binding site 1 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn901 b:10.8 occ:0.33 NE2 B:HIS10 2.0 11.5 1.0 CL B:CL902 2.2 18.7 0.3 CE1 B:HIS10 2.9 11.7 1.0 CD2 B:HIS10 3.1 10.7 1.0 HE1 B:HIS10 3.2 14.2 1.0 HD2 B:HIS10 3.3 13.7 1.0 ND1 B:HIS10 4.1 12.3 1.0 CG B:HIS10 4.2 11.2 1.0 O B:HOH1214 4.2 33.7 0.3 HD1 B:HIS10 5.0 10.5 1.0 O B:HOH1271 5.0 38.7 1.0

Zinc binding site 2 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn951 b:16.3 occ:0.60 HE2 B:HIS5 1.6 20.1 0.4 NE2 B:HIS5 1.9 14.6 0.6 HE1 B:HIS5 2.1 21.0 0.4 NE2 B:HIS5 2.2 20.2 0.4 O B:HOH952 2.2 12.3 0.6 O B:HOH953 2.4 17.1 0.6 CE1 B:HIS5 2.5 21.4 0.4 CE1 B:HIS5 2.9 16.1 0.6 CD2 B:HIS5 3.0 15.2 0.6 HE1 B:HIS5 3.1 17.3 0.6 HD13 A:ILE10 3.2 20.3 1.0 HD2 B:HIS5 3.3 15.9 0.6 CD2 B:HIS5 3.6 19.5 0.4 ND1 B:HIS5 3.7 19.8 0.4 HG13 A:ILE10 4.0 21.2 1.0 ND1 B:HIS5 4.0 14.7 0.6 CG B:HIS5 4.1 11.6 0.6 CD1 A:ILE10 4.2 23.6 1.0 HD2 B:HIS5 4.2 19.9 0.4 CG B:HIS5 4.3 19.4 0.4 HD12 A:ILE10 4.4 20.9 1.0 O B:HOH962 4.5 13.7 0.4 CG1 A:ILE10 4.6 22.2 1.0 O B:HOH1810 4.7 26.4 0.6 ZN B:ZN961 4.8 20.1 0.4 HD1 B:HIS5 4.9 16.0 0.6 HD11 A:ILE10 5.0 22.6 1.0 HA A:SER9 5.0 19.7 1.0

Zinc binding site 3 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn961 b:20.1 occ:0.40 O B:HOH962 1.7 13.7 0.4 HD2 B:HIS5 1.8 15.9 0.6 ND1 B:HIS5 1.8 19.8 0.4 O B:HOH963 2.2 15.9 0.4 O B:HOH1811 2.2 27.4 0.6 O B:HOH964 2.2 23.0 0.4 CE1 B:HIS5 2.6 21.4 0.4 O B:HOH1810 2.7 26.4 0.6 HE1 B:HIS5 2.7 21.0 0.4 CD2 B:HIS5 2.8 15.2 0.6 HB2 B:HIS5 2.8 14.0 0.6 CG B:HIS5 3.0 19.4 0.4 HB2 B:HIS5 3.1 16.8 0.4 H B:HIS5 3.3 15.5 0.6 H B:HIS5 3.3 15.5 0.4 CG B:HIS5 3.4 11.6 0.6 CB B:HIS5 3.6 16.9 0.4 CB B:HIS5 3.6 15.1 0.6 NE2 B:HIS5 3.7 20.2 0.4 CD2 B:HIS5 3.9 19.5 0.4 NE2 B:HIS5 3.9 14.6 0.6 O B:HOH952 4.1 12.3 0.6 N B:HIS5 4.2 14.2 0.6 N B:HIS5 4.2 15.2 0.4 HB3 B:HIS5 4.4 15.2 0.6 HB3 B:HIS5 4.4 17.6 0.4 HB2 B:GLN4 4.4 21.3 1.0 CA B:HIS5 4.5 11.7 0.6 CA B:HIS5 4.5 14.1 0.4 HE2 B:HIS5 4.5 20.1 0.4 ND1 B:HIS5 4.7 14.7 0.6 ZN B:ZN951 4.8 16.3 0.6 CE1 B:HIS5 4.9 16.1 0.6 HD2 B:HIS5 5.0 19.9 0.4 HA B:GLN4 5.0 20.0 1.0

Zinc binding site 4 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn911 b:9.2 occ:0.45 O D:HOH1814 0.7 9.2 0.6 NE2 D:HIS10 2.0 8.5 0.5 CL D:CL912 2.2 10.9 0.5 O D:HOH1812 2.5 12.1 0.6 CD2 D:HIS10 3.0 9.8 0.5 CE1 D:HIS10 3.1 11.8 0.5 HD2 D:HIS10 3.1 11.2 0.5 HE1 D:HIS10 3.3 14.3 0.5 O D:HOH1801 3.4 19.0 0.6 HB3 D:LEU6 3.8 12.3 1.0 HD22 D:LEU6 4.0 15.1 1.0 HD13 D:LEU6 4.1 15.9 1.0 CG D:HIS10 4.1 9.6 0.5 ND1 D:HIS10 4.1 14.7 0.5 HB2 D:HIS10 4.4 11.1 0.6 CB D:LEU6 4.7 10.8 1.0 O D:HOH1225 4.8 34.0 1.0 O D:LEU6 4.8 10.2 1.0 CD2 D:LEU6 4.8 13.7 1.0 HD21 D:LEU6 4.9 14.2 1.0 CD1 D:LEU6 5.0 14.1 1.0

Zinc binding site 5 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn921 b:9.6 occ:0.55 NE2 D:HIS10 2.0 7.8 0.6 CL D:CL923 2.2 12.8 0.6 CL D:CL922 2.3 10.6 0.6 CD2 D:HIS10 3.0 7.0 0.6 CE1 D:HIS10 3.0 9.3 0.6 HD2 D:HIS10 3.2 12.8 0.6 HE1 D:HIS10 3.3 10.8 0.6 O C:HOH1138 3.8 20.7 1.0 HB3 D:ALA14 4.0 10.7 1.0 ND1 D:HIS10 4.1 10.0 0.6 CG D:HIS10 4.1 7.4 0.6 HB3 D:HIS10 4.3 9.7 0.5 HG21 C:ILE10 4.4 20.9 1.0 O D:HOH1179 4.5 27.6 1.0 HB2 D:ALA14 4.7 9.8 1.0 HD11 C:LEU16 4.8 14.6 1.0 HD22 D:LEU11 4.8 15.2 1.0 CB D:ALA14 4.8 9.3 1.0 O C:HOH1935 4.9 14.0 0.3 O C:HOH1114 5.0 14.9 1.0 HD1 D:HIS10 5.0 11.1 0.6

Zinc binding site 6 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn931 b:9.3 occ:0.33 NE2 F:HIS10 2.0 9.1 1.0 CL F:CL932 2.1 15.3 0.5 O F:HOH933 2.4 14.4 0.5 CE1 F:HIS10 2.9 12.6 1.0 CD2 F:HIS10 3.1 7.5 1.0 HE1 F:HIS10 3.2 14.9 1.0 HD2 F:HIS10 3.3 11.1 1.0 H22 F:ACN992 3.7 21.2 1.0 ND1 F:HIS10 4.1 12.1 1.0 O F:HOH1803 4.1 25.6 0.5 CG F:HIS10 4.2 8.2 1.0 HE2 D:PHE1 4.2 21.5 0.5 O F:HOH1804 4.4 18.8 0.5 C2 F:ACN992 4.8 24.3 1.0 HD1 F:HIS10 5.0 13.2 1.0

Zinc binding site 7 out of 7 in the 1.2 A Structure of T3R3 Human Insulin at 100 K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of 1.2 A Structure of T3R3 Human Insulin at 100 K within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn941 b:11.4 occ:0.33 NE2 H:HIS10 2.0 10.9 1.0 CL H:CL942 2.3 14.6 0.3 CE1 H:HIS10 3.0 13.8 1.0 CD2 H:HIS10 3.0 10.9 1.0 HE1 H:HIS10 3.2 14.1 1.0 HD2 H:HIS10 3.2 14.7 1.0 HB3 H:LEU6 3.7 17.6 1.0 ND1 H:HIS10 4.1 13.5 1.0 CG H:HIS10 4.1 9.7 1.0 HD12 H:LEU6 4.5 19.6 1.0 HD23 H:LEU6 4.6 17.9 1.0 CB H:LEU6 4.7 17.0 1.0 O H:LEU6 4.8 12.9 1.0 HD1 H:HIS10 5.0 14.4 1.0

G.D.Smith, W.A.Pangborn, R.H.Blessing. Phase Changes in T(3)R(3)(F) Human Insulin: Temperature or Pressure Induced? Acta Crystallogr.,Sect.D V. 57 1091 2001.
ISSN: ISSN 0907-4449
PubMed: 11468392
DOI: 10.1107/S0907444901007685