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Zinc in PDB 1eou: Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate

Enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate

All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate:
4.2.1.1;

Protein crystallography data

The structure of Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate, PDB code: 1eou was solved by R.Recacha, M.J.Costanzo, B.E.Maryanoff, D.Chattopadhyay, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.99 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.275, 41.390, 72.509, 90.00, 104.11, 90.00
R / Rfree (%) 17.6 / 22.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate (pdb code 1eou). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate, PDB code: 1eou:

Zinc binding site 1 out of 1 in 1eou

Go back to Zinc Binding Sites List in 1eou
Zinc binding site 1 out of 1 in the Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anticonvulsant Sugar Sulfamate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn300

b:9.5
occ:1.00
 NE2 A:HIS94 2.0 3.5 1.0
ND1 A:HIS119 2.0 5.8 1.0
NE2 A:HIS96 2.1 8.0 1.0
N1 A:SMS301 2.1 7.8 1.0
CD2 A:HIS96 2.8 7.6 1.0
CD2 A:HIS94 2.9 4.1 1.0
CE1 A:HIS119 2.9 5.7 1.0
CE1 A:HIS94 3.0 3.9 1.0
CG A:HIS119 3.1 5.8 1.0
O10 A:SMS301 3.1 7.9 1.0
S2 A:SMS301 3.1 8.3 1.0
CE1 A:HIS96 3.2 7.8 1.0
CB A:HIS119 3.5 5.4 1.0
O8 A:SMS301 3.6 9.3 1.0
OG1 A:THR198 3.8 7.5 1.0
OE1 A:GLU106 4.0 5.7 1.0
ND1 A:HIS94 4.1 3.2 1.0
CG A:HIS96 4.1 7.1 1.0
CG A:HIS94 4.1 4.2 1.0
NE2 A:HIS119 4.1 5.7 1.0
CD2 A:HIS119 4.2 5.7 1.0
C9 A:SMS301 4.2 13.2 1.0
ND1 A:HIS96 4.2 6.0 1.0
O9 A:SMS301 4.3 8.4 1.0
CD A:GLU106 4.9 5.8 1.0
C1 A:SMS301 4.9 10.8 1.0
CH2 A:TRP208 4.9 5.5 1.0
CA A:HIS119 5.0 5.7 1.0

Reference:

R.Recacha, M.J.Costanzo, B.E.Maryanoff, D.Chattopadhyay. Crystal Structure of Human Carbonic Anhydrase II Complexed with An Anti-Convulsant Sugar Sulphamate. Biochem.J. V. 361 437 2002.
ISSN: ISSN 0264-6021
PubMed: 11802772
DOI: 10.1042/0264-6021:3610437
Page generated: Sun Oct 13 00:21:47 2024

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