Zinc in PDB 1eh7: Methylated Human O6-Alkylguanine-Dna Alkyltransferase

All present enzymatic activity of Methylated Human O6-Alkylguanine-Dna Alkyltransferase:
2.1.1.63;

The structure of Methylated Human O6-Alkylguanine-Dna Alkyltransferase, PDB code: 1eh7 was solved by D.S.Daniels, J.A.Tainer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.23 / 2.00
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	71.401, 71.401, 76.325, 90.00, 90.00, 120.00
R / Rfree (%)	19.9 / 22.9

The binding sites of Zinc atom in the Methylated Human O6-Alkylguanine-Dna Alkyltransferase (pdb code 1eh7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Methylated Human O6-Alkylguanine-Dna Alkyltransferase, PDB code: 1eh7:

Zinc binding site 1 out of 1 in the Methylated Human O6-Alkylguanine-Dna Alkyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Methylated Human O6-Alkylguanine-Dna Alkyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn208 b:35.3 occ:0.70 NE2 A:HIS29 2.1 33.9 1.0 ND1 A:HIS85 2.1 33.6 1.0 SG A:CYS24 2.4 32.3 1.0 SG A:CYS5 2.4 43.6 1.0 CD2 A:HIS29 3.0 32.9 1.0 CE1 A:HIS85 3.0 33.6 1.0 CE1 A:HIS29 3.1 33.6 1.0 CG A:HIS85 3.1 33.1 1.0 CB A:HIS85 3.5 32.0 1.0 CB A:CYS24 3.7 32.3 1.0 O A:HIS85 3.9 32.1 1.0 CB A:CYS5 4.1 45.6 1.0 CG A:HIS29 4.2 32.1 1.0 NE2 A:HIS85 4.2 33.8 1.0 ND1 A:HIS29 4.2 33.0 1.0 CD2 A:HIS85 4.3 33.3 1.0 C A:HIS85 4.5 31.6 1.0 CB A:GLN26 4.6 33.7 1.0 O A:GLY27 4.7 28.5 1.0 CA A:HIS85 4.7 31.3 1.0 N A:CYS24 4.7 31.3 1.0 CA A:CYS24 4.8 32.2 1.0 CA A:CYS5 4.9 45.6 1.0

D.S.Daniels, C.D.Mol, A.S.Arvai, S.Kanugula, A.E.Pegg, J.A.Tainer. Active and Alkylated Human Agt Structures: A Novel Zinc Site, Inhibitor and Extrahelical Base Binding. Embo J. V. 19 1719 2000.
ISSN: ISSN 0261-4189
PubMed: 10747039
DOI: 10.1093/EMBOJ/19.7.1719