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Zinc in PDB 1bzm: Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

Enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

All present enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I:
4.2.1.1;

Protein crystallography data

The structure of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1bzm was solved by S.Chakravarty, K.K.Kannan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 81.850, 75.310, 37.760, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I (pdb code 1bzm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1bzm:

Zinc binding site 1 out of 1 in 1bzm

Go back to Zinc Binding Sites List in 1bzm
Zinc binding site 1 out of 1 in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn261

b:6.7
occ:0.99
 NE2 A:HIS94 2.0 3.5 1.0
N1 A:MZM262 2.0 6.9 1.0
ND1 A:HIS119 2.1 6.0 1.0
NE2 A:HIS96 2.2 6.7 1.0
CD2 A:HIS94 2.9 5.8 1.0
CE1 A:HIS119 2.9 4.5 1.0
CD2 A:HIS96 3.0 5.8 1.0
CE1 A:HIS94 3.0 7.2 1.0
O1 A:MZM262 3.1 6.9 1.0
CG A:HIS119 3.1 6.1 1.0
S1 A:MZM262 3.1 7.3 1.0
CE1 A:HIS96 3.4 6.1 1.0
CB A:HIS119 3.6 5.1 1.0
NE2 A:HIS119 4.1 6.8 1.0
OE1 A:GLU106 4.1 8.3 1.0
O2 A:MZM262 4.1 7.0 0.9
CG A:HIS94 4.1 6.1 1.0
OG1 A:THR199 4.1 3.6 1.0
ND1 A:HIS94 4.1 4.6 1.0
C1 A:MZM262 4.2 7.8 0.7
CD2 A:HIS119 4.2 6.7 1.0
CG A:HIS96 4.2 6.0 1.0
NE2 A:HIS200 4.3 11.1 1.0
ND1 A:HIS96 4.4 5.9 1.0
O A:HOH305 4.7 7.8 1.0
O A:HOH304 4.8 9.9 1.0
CD2 A:HIS200 4.8 8.5 1.0
N3 A:MZM262 4.9 7.9 0.8

Reference:

S.Chakravarty, K.K.Kannan. Drug-Protein Interactions. Refined Structures of Three Sulfonamide Drug Complexes of Human Carbonic Anhydrase I Enzyme. J.Mol.Biol. V. 243 298 1994.
ISSN: ISSN 0022-2836
PubMed: 7932756
DOI: 10.1006/JMBI.1994.1655
Page generated: Sat Oct 12 22:49:02 2024

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