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Zinc in PDB 1aui: Human Calcineurin Heterodimer

Enzymatic activity of Human Calcineurin Heterodimer

All present enzymatic activity of Human Calcineurin Heterodimer:
3.1.3.16;

Protein crystallography data

The structure of Human Calcineurin Heterodimer, PDB code: 1aui was solved by C.R.Kissinger, H.E.Parge, D.R.Knighton, L.A.Pelletier, C.T.Lewis, A.Tempczyk, J.E.Villafranca, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.810, 104.340, 177.770, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / n/a

Other elements in 1aui:

The structure of Human Calcineurin Heterodimer also contains other interesting chemical elements:

Iron (Fe) 1 atom
Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Calcineurin Heterodimer (pdb code 1aui). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Calcineurin Heterodimer, PDB code: 1aui:

Zinc binding site 1 out of 1 in 1aui

Go back to Zinc Binding Sites List in 1aui
Zinc binding site 1 out of 1 in the Human Calcineurin Heterodimer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Calcineurin Heterodimer within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn522

b:63.8
occ:1.00
OD1 A:ASN150 2.1 28.1 1.0
ND1 A:HIS281 2.3 32.9 1.0
NE2 A:HIS199 2.3 35.8 1.0
O A:HOH778 2.4 57.4 1.0
OD2 A:ASP118 2.6 22.1 1.0
CG A:ASN150 3.1 20.7 1.0
FE A:FE523 3.1 37.3 1.0
CE1 A:HIS281 3.1 17.2 1.0
CD2 A:HIS199 3.3 21.1 1.0
CE1 A:HIS199 3.3 22.1 1.0
CG A:HIS281 3.4 18.3 1.0
CG A:ASP118 3.5 18.0 1.0
CA A:HIS281 3.5 30.9 1.0
ND2 A:ASN150 3.7 21.5 1.0
OD1 A:ASP118 3.8 20.9 1.0
CB A:HIS281 3.8 33.4 1.0
O A:HIS281 3.9 33.6 1.0
O A:HOH697 4.1 45.5 1.0
OD2 A:ASP90 4.2 29.2 1.0
C A:HIS281 4.2 25.5 1.0
O A:HOH796 4.3 60.5 1.0
CB A:ASN150 4.3 20.3 1.0
NE2 A:HIS281 4.4 25.9 1.0
CD2 A:HIS151 4.4 26.9 1.0
N A:ASN150 4.4 19.3 1.0
ND1 A:HIS199 4.4 23.3 1.0
CG A:HIS199 4.4 23.6 1.0
N A:HIS281 4.5 24.9 1.0
CD2 A:HIS281 4.5 27.4 1.0
O A:LEU231 4.7 28.4 1.0
CB A:ASP118 4.7 15.6 1.0
O A:HOH627 4.8 37.9 1.0
OD1 A:ASP90 4.8 22.8 1.0
NH1 A:ARG254 4.9 31.8 1.0
CG A:ASP90 4.9 30.3 1.0
CA A:ASN150 4.9 32.3 1.0
NE2 A:HIS151 4.9 19.7 1.0

Reference:

C.R.Kissinger, H.E.Parge, D.R.Knighton, C.T.Lewis, L.A.Pelletier, A.Tempczyk, V.J.Kalish, K.D.Tucker, R.E.Showalter, E.W.Moomaw, L.N.Gastinel, N.Habuka, X.Chen, F.Maldonado, J.E.Barker, R.Bacquet, J.E.Villafranca. Crystal Structures of Human Calcineurin and the Human FKBP12-FK506-Calcineurin Complex. Nature V. 378 641 1995.
ISSN: ISSN 0028-0836
PubMed: 8524402
DOI: 10.1038/378641A0
Page generated: Sat Oct 12 22:16:31 2024

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