Zinc in PDB 8uh6: Degrader-Induced Complex Between PTPN2 and Crbn-DDB1

Enzymatic activity of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1

All present enzymatic activity of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1:
3.1.3.48;

Other elements in 8uh6:

The structure of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 (pdb code 8uh6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1, PDB code: 8uh6:

Zinc binding site 1 out of 1 in 8uh6

Go back to Zinc Binding Sites List in 8uh6
Zinc binding site 1 out of 1 in the Degrader-Induced Complex Between PTPN2 and Crbn-DDB1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Degrader-Induced Complex Between PTPN2 and Crbn-DDB1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn502

b:254.2
occ:1.00
CB B:CYS394 1.9 180.5 1.0
SG B:CYS323 2.3 160.6 1.0
SG B:CYS326 2.3 140.0 1.0
SG B:CYS391 2.3 164.5 1.0
SG B:CYS394 2.3 186.4 1.0
CB B:CYS323 3.2 150.8 1.0
CA B:CYS394 3.3 178.5 1.0
N B:CYS394 3.7 178.0 1.0
O B:CYS394 3.8 179.4 1.0
C B:CYS394 3.9 177.7 1.0
OG B:SER396 4.0 148.7 1.0
CB B:CYS391 4.0 161.1 1.0
CG B:GLN325 4.1 139.6 1.0
CB B:CYS326 4.1 138.9 1.0
NE2 B:GLN325 4.2 142.0 1.0
N B:CYS326 4.4 139.9 1.0
CD B:GLN325 4.5 141.8 1.0
CG2 B:THR329 4.5 151.4 1.0
CA B:CYS323 4.7 151.6 1.0
CA B:CYS326 4.8 139.9 1.0
C B:ILE393 4.9 161.8 1.0
O B:CYS326 4.9 142.6 1.0

Reference:

Q.Hao, M.K.Rathinaswamy, K.L.Klinge, M.Bratkowski, A.Mafi, C.K.Baumgartner, K.M.Hamel, G.K.Veits, R.Jain, C.Catalano, M.Fitzgerald, A.W.Hird, E.Park, H.U.Vora, J.A.Henderson, K.Longenecker, C.W.Hutchins, W.Qiu, G.Scapin, Q.Sun, V.S.Stoll, C.Sun, P.Li, D.Eaton, D.Stokoe, S.L.Fisher, C.G.Nasveschuk, M.Paddock, M.E.Kort. Mechanistic Insights Into A Heterobifunctional Degrader-Induced PTPN2/N1 Complex. Commun Chem V. 7 183 2024.
ISSN: ESSN 2399-3669
PubMed: 39152201
DOI: 10.1038/S42004-024-01263-7
Page generated: Thu Oct 31 12:15:17 2024

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