Zinc in PDB 8tqc: Structure of the Human CDK8 Kinase Module

The binding sites of Zinc atom in the Structure of the Human CDK8 Kinase Module (pdb code 8tqc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of the Human CDK8 Kinase Module, PDB code: 8tqc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of the Human CDK8 Kinase Module


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Human CDK8 Kinase Module within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2201 b:62.6 occ:1.00 NE2 C:HIS1729 2.0 24.3 1.0 ND1 C:HIS1727 2.0 22.0 1.0 SG D:CYS1899 2.3 28.0 1.0 SG D:CYS1896 2.3 34.4 1.0 CD2 C:HIS1729 2.6 24.3 1.0 CB D:CYS1896 2.6 34.4 1.0 CG C:HIS1727 3.0 22.0 1.0 CE1 C:HIS1729 3.1 24.3 1.0 CE1 C:HIS1727 3.1 22.0 1.0 CB C:HIS1727 3.2 22.0 1.0 CG C:HIS1729 3.7 24.3 1.0 CA C:HIS1727 3.7 22.0 1.0 O C:HIS1727 3.7 22.0 1.0 ND1 C:HIS1729 3.9 24.3 1.0 C C:HIS1727 3.9 22.0 1.0 CB D:CYS1899 4.0 28.0 1.0 CA D:CYS1896 4.1 34.4 1.0 CD2 C:HIS1727 4.1 22.0 1.0 NE2 C:HIS1727 4.1 22.0 1.0 N D:CYS1899 4.3 28.0 1.0 CA D:CYS1899 4.7 28.0 1.0 N C:THR1728 4.8 23.1 1.0 C D:CYS1896 4.9 34.4 1.0 N D:CYS1896 4.9 34.4 1.0 CB C:HIS1729 4.9 24.3 1.0 N C:HIS1729 4.9 24.3 1.0

Zinc binding site 2 out of 2 in the Structure of the Human CDK8 Kinase Module


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Human CDK8 Kinase Module within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2201 b:34.5 occ:1.00 SG D:CYS1096 2.3 24.6 1.0 SG D:CYS1124 2.3 27.9 1.0 SG D:CYS1122 2.3 33.0 1.0 SG D:CYS1098 2.3 33.9 1.0 CB D:CYS1098 3.4 33.9 1.0 CB D:CYS1122 3.4 33.0 1.0 CB D:CYS1124 3.6 27.9 1.0 CA D:CYS1122 3.7 33.0 1.0 N D:CYS1124 3.7 27.9 1.0 N D:CYS1098 3.8 33.9 1.0 CB D:CYS1096 3.8 24.6 1.0 C D:CYS1122 4.0 33.0 1.0 CA D:CYS1124 4.2 27.9 1.0 N D:THR1123 4.2 33.6 1.0 CA D:CYS1098 4.2 33.9 1.0 N D:VAL1097 4.3 27.0 1.0 CA D:CYS1096 4.3 24.6 1.0 C D:CYS1096 4.5 24.6 1.0 C D:CYS1124 4.6 27.9 1.0 O D:CYS1122 4.7 33.0 1.0 O D:CYS1124 4.7 27.9 1.0 C D:THR1123 4.8 33.6 1.0 C D:VAL1097 4.9 27.0 1.0 NE2 D:GLN2061 4.9 20.7 1.0 CB D:PHE1126 5.0 17.3 1.0

T.C.Chao, S.F.Chen, H.J.Kim, H.C.Tang, H.C.Tseng, A.Xu, L.Palao 3Rd, S.Khadka, T.Li, M.F.Huang, D.F.Lee, K.Murakami, T.G.Boyer, K.L.Tsai. Structural Basis of the Human Transcriptional Mediator Regulated By Its Dissociable Kinase Module. Mol.Cell 2024.
ISSN: ISSN 1097-2765
PubMed: 39321804
DOI: 10.1016/J.MOLCEL.2024.09.001