Zinc in PDB 8t68: Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111

Enzymatic activity of Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111

All present enzymatic activity of Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111:
2.1.1.361; 2.1.1.362;

Protein crystallography data

The structure of Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111, PDB code: 8t68 was solved by H.Zeng, A.Dong, P.J.Brown, C.H.Arrowsmith, A.M.Edwards, L.Halabelian, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.76 / 1.90
Space group P 2 21 21
Cell size a, b, c (Å), α, β, γ (°) 36.149, 75.528, 96.807, 90, 90, 90
R / Rfree (%) 22.6 / 26.4

Other elements in 8t68:

The structure of Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111 (pdb code 8t68). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111, PDB code: 8t68:

Zinc binding site 1 out of 1 in 8t68

Go back to Zinc Binding Sites List in 8t68
Zinc binding site 1 out of 1 in the Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Set Domain of Human Histone-Lysine N- Methyltransferase SUV420H1 in Complex with RQ3-111 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:23.4
occ:1.00
 SG A:CYS319 2.3 22.8 1.0
SG A:CYS321 2.3 24.5 1.0
SG A:CYS275 2.4 23.5 1.0
SG A:CYS324 2.4 22.2 1.0
CB A:CYS319 3.2 20.9 1.0
CB A:CYS321 3.4 22.1 1.0
CB A:CYS324 3.4 23.7 1.0
CB A:CYS275 3.5 24.3 1.0
N A:CYS275 4.0 24.6 1.0
N A:CYS321 4.1 21.7 1.0
N A:CYS324 4.2 26.9 1.0
NE2 A:HIS273 4.2 21.8 1.0
CA A:CYS321 4.2 23.1 1.0
O A:HOH524 4.2 41.4 1.0
CD2 A:HIS273 4.3 19.8 1.0
CA A:CYS324 4.3 28.1 1.0
CA A:CYS275 4.4 24.3 1.0
CA A:CYS319 4.5 22.2 1.0
C A:CYS319 4.6 19.9 1.0
O A:CYS321 4.7 19.5 1.0
C A:CYS321 4.8 22.9 1.0
O A:CYS319 4.8 20.2 1.0
C A:ASP274 5.0 25.0 1.0
O A:HOH556 5.0 32.2 1.0

Reference:

H.Zeng, A.Dong, P.J.Brown, C.H.Arrowsmith, A.M.Edwards, L.Halabelian, Structural Genomics Consortium (Sgc). Crystal Structure of the Set Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 in Complex with RQ3-111. To Be Published.
Page generated: Tue Dec 10 21:52:46 2024

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