Zinc in PDB 8qhg: Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid)

Protein crystallography data

The structure of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid), PDB code: 8qhg was solved by C.Baroni, M.Ferraroni, F.Carta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 78.67 / 1.91
Space group I 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 157.33, 157.33, 157.33, 90, 90, 90
R / Rfree (%) 19.2 / 22

Other elements in 8qhg:

The structure of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) also contains other interesting chemical elements:

Nickel (Ni) 1 atom
Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) (pdb code 8qhg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid), PDB code: 8qhg:

Zinc binding site 1 out of 1 in 8qhg

Go back to Zinc Binding Sites List in 8qhg
Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:24.6
occ:1.00
NE2 A:HIS94 2.0 22.8 1.0
NE2 A:HIS96 2.0 23.9 1.0
N11 A:V8I301 2.0 25.1 1.0
ND1 A:HIS119 2.0 27.5 1.0
CE1 A:HIS94 3.0 23.6 1.0
CE1 A:HIS119 3.0 27.7 1.0
CD2 A:HIS96 3.0 26.4 1.0
CE1 A:HIS96 3.0 24.3 1.0
CD2 A:HIS94 3.0 22.9 1.0
CG A:HIS119 3.1 27.5 1.0
S10 A:V8I301 3.1 26.6 1.0
O13 A:V8I301 3.1 26.7 1.0
CB A:HIS119 3.5 27.6 1.0
OG1 A:THR199 3.9 24.3 1.0
C7 A:V8I301 3.9 29.1 1.0
OE1 A:GLU106 4.0 29.4 1.0
C6 A:V8I301 4.0 25.6 1.0
ND1 A:HIS94 4.1 24.8 1.0
NE2 A:HIS119 4.1 28.3 1.0
ND1 A:HIS96 4.1 26.6 1.0
CG A:HIS94 4.1 23.6 1.0
CG A:HIS96 4.1 25.7 1.0
CD2 A:HIS119 4.2 28.7 1.0
O12 A:V8I301 4.2 25.9 1.0
CD A:GLU106 4.8 24.3 1.0
CA A:HIS119 5.0 25.8 1.0

Reference:

C.Baroni, M.Ferraroni, F.Carta. Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4-Dichloro 5-Sulfamoyl Benzoic Acid) To Be Published.
Page generated: Thu Oct 31 10:04:24 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy