Zinc in PDB 8f1d: Voltage-Gated Potassium Channel KV3.1 Apo

The structure of Voltage-Gated Potassium Channel KV3.1 Apo also contains other interesting chemical elements:

Potassium

(K)

4 atoms

The binding sites of Zinc atom in the Voltage-Gated Potassium Channel KV3.1 Apo (pdb code 8f1d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Voltage-Gated Potassium Channel KV3.1 Apo, PDB code: 8f1d:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Voltage-Gated Potassium Channel KV3.1 Apo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Voltage-Gated Potassium Channel KV3.1 Apo within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:252.0 occ:1.00 ND1 A:HIS77 2.0 179.9 1.0 SG A:CYS105 2.3 202.4 1.0 SG B:CYS83 2.3 207.6 1.0 SG A:CYS104 2.3 193.0 1.0 CB A:CYS105 2.8 195.0 1.0 CE1 A:HIS77 3.0 179.0 1.0 CG A:HIS77 3.1 179.9 1.0 CB B:CYS83 3.2 196.9 1.0 CB A:HIS77 3.4 180.7 1.0 N A:CYS105 3.6 192.8 1.0 CA A:CYS105 3.8 192.8 1.0 CB A:CYS104 4.0 190.3 1.0 C A:CYS104 4.0 190.2 1.0 CA A:HIS77 4.0 178.5 1.0 NE2 A:HIS77 4.1 178.4 1.0 CD2 A:HIS77 4.2 179.0 1.0 O A:CYS104 4.5 189.5 1.0 N A:CYS78 4.5 180.6 1.0 CA A:CYS104 4.5 190.4 1.0 CA B:CYS83 4.7 196.2 1.0 C A:HIS77 4.8 178.7 1.0 C A:CYS105 4.9 191.9 1.0 CB A:GLU102 5.0 184.0 1.0

Zinc binding site 2 out of 4 in the Voltage-Gated Potassium Channel KV3.1 Apo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Voltage-Gated Potassium Channel KV3.1 Apo within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:250.9 occ:1.00 ND1 B:HIS77 2.0 180.3 1.0 SG B:CYS105 2.3 203.0 1.0 SG C:CYS83 2.3 206.7 1.0 SG B:CYS104 2.3 193.7 1.0 CB B:CYS105 2.8 195.3 1.0 CE1 B:HIS77 3.0 179.3 1.0 CG B:HIS77 3.1 180.4 1.0 CB C:CYS83 3.2 196.2 1.0 CB B:HIS77 3.4 181.3 1.0 N B:CYS105 3.6 192.7 1.0 CA B:CYS105 3.8 193.1 1.0 CB B:CYS104 4.0 190.9 1.0 C B:CYS104 4.0 190.4 1.0 CA B:HIS77 4.0 178.9 1.0 NE2 B:HIS77 4.1 178.7 1.0 CD2 B:HIS77 4.2 179.6 1.0 O B:CYS104 4.5 189.9 1.0 N B:CYS78 4.5 181.8 1.0 CA B:CYS104 4.5 190.8 1.0 CA C:CYS83 4.7 195.7 1.0 C B:HIS77 4.8 179.3 1.0 C B:CYS105 4.9 192.1 1.0 CB B:GLU102 5.0 184.7 1.0

Zinc binding site 3 out of 4 in the Voltage-Gated Potassium Channel KV3.1 Apo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Voltage-Gated Potassium Channel KV3.1 Apo within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn601 b:248.5 occ:1.00 ND1 C:HIS77 2.1 180.0 1.0 SG C:CYS105 2.3 202.4 1.0 SG D:CYS83 2.3 206.4 1.0 SG C:CYS104 2.3 193.6 1.0 CB C:CYS105 2.8 195.0 1.0 CE1 C:HIS77 3.0 179.1 1.0 CG C:HIS77 3.1 180.1 1.0 CB D:CYS83 3.2 196.0 1.0 CB C:HIS77 3.4 180.8 1.0 N C:CYS105 3.6 192.7 1.0 CA C:CYS105 3.8 192.9 1.0 CB C:CYS104 4.0 191.1 1.0 C C:CYS104 4.0 190.5 1.0 CA C:HIS77 4.0 178.3 1.0 NE2 C:HIS77 4.1 178.6 1.0 CD2 C:HIS77 4.2 179.4 1.0 O C:CYS104 4.5 189.8 1.0 N C:CYS78 4.5 180.9 1.0 CA C:CYS104 4.5 191.0 1.0 CA D:CYS83 4.7 195.5 1.0 C C:HIS77 4.8 178.8 1.0 C C:CYS105 4.9 192.2 1.0 CB C:GLU102 5.0 185.2 1.0

Zinc binding site 4 out of 4 in the Voltage-Gated Potassium Channel KV3.1 Apo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Voltage-Gated Potassium Channel KV3.1 Apo within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn601 b:249.6 occ:1.00 ND1 D:HIS77 2.1 179.5 1.0 SG D:CYS105 2.3 201.6 1.0 SG D:CYS104 2.3 194.1 1.0 SG A:CYS83 2.3 206.5 1.0 CB D:CYS105 2.8 194.1 1.0 CE1 D:HIS77 3.0 178.7 1.0 CG D:HIS77 3.1 179.6 1.0 CB A:CYS83 3.2 196.1 1.0 CB D:HIS77 3.4 180.5 1.0 N D:CYS105 3.6 191.9 1.0 CA D:CYS105 3.8 191.8 1.0 CB D:CYS104 4.0 190.8 1.0 C D:CYS104 4.0 190.3 1.0 CA D:HIS77 4.0 178.1 1.0 NE2 D:HIS77 4.1 178.2 1.0 CD2 D:HIS77 4.2 178.9 1.0 O D:CYS104 4.5 189.4 1.0 N D:CYS78 4.5 179.4 1.0 CA D:CYS104 4.5 190.6 1.0 CA A:CYS83 4.7 195.8 1.0 C D:HIS77 4.8 178.2 1.0 C D:CYS105 4.9 191.0 1.0 CB D:GLU102 5.0 183.3 1.0

Y.T.Chen, M.R.Hong, X.J.Zhang, J.Kostas, Y.Li, R.L.Kraus, V.P.Santarelli, D.Wang, Y.Gomez-Llorente, A.Brooun, C.Strickland, S.M.Soisson, D.J.Klein, A.T.Ginnetti, M.J.Marino, S.J.Stachel, A.Ishchenko. Identification and Structural and Biophysical Characterization of A Positive Modulator of Human KV3.1 Channels. Proc.Natl.Acad.Sci.Usa V. 120 29120 2023.
ISSN: ESSN 1091-6490
PubMed: 37812700
DOI: 10.1073/PNAS.2220029120