Zinc in PDB 8c9g: Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin

All present enzymatic activity of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin:
6.1.1.5;

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g was solved by A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	60.39 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	66.82, 144.28, 108.37, 90, 95.64, 90
R / Rfree (%)	20 / 25.8

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin also contains other interesting chemical elements:

Sodium	(Na)	3 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Zinc atom in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin (pdb code 8c9g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:51.9 occ:1.00 SG A:CYS890 2.3 59.1 1.0 SG A:CYS910 2.3 63.3 1.0 SG A:CYS887 2.3 47.8 1.0 SG A:CYS907 2.3 58.1 1.0 CB A:CYS910 3.1 59.8 1.0 CB A:CYS887 3.2 49.8 1.0 CB A:CYS890 3.2 54.7 1.0 N A:CYS890 3.6 53.4 1.0 CB A:CYS907 3.8 53.5 1.0 CA A:CYS890 4.0 46.5 1.0 N A:CYS907 4.0 49.2 1.0 NH1 A:ARG909 4.2 55.0 1.0 N A:CYS910 4.3 61.0 1.0 CA A:CYS910 4.3 59.3 1.0 CG1 A:VAL892 4.4 55.2 1.0 CA A:CYS907 4.5 60.9 1.0 CB A:ARG889 4.5 52.4 1.0 CA A:CYS887 4.7 53.0 1.0 C A:CYS890 4.7 47.7 1.0 C A:ARG889 4.7 50.5 1.0 CZ A:ARG909 4.9 60.3 1.0 N A:TRP891 4.9 52.6 1.0 N A:ARG889 4.9 53.2 1.0 CA A:ARG889 4.9 46.7 1.0

Zinc binding site 2 out of 2 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:71.2 occ:1.00 SG B:CYS890 2.3 49.9 1.0 SG B:CYS910 2.3 71.7 1.0 SG B:CYS907 2.3 57.6 1.0 SG B:CYS887 2.3 52.1 1.0 CB B:CYS910 3.2 65.5 1.0 CB B:CYS887 3.3 68.5 1.0 CB B:CYS890 3.6 53.6 1.0 CB B:CYS907 3.6 65.6 1.0 N B:CYS890 3.7 67.7 1.0 N B:CYS907 3.9 63.6 1.0 N B:CYS910 4.2 74.6 1.0 NH2 B:ARG909 4.2 81.4 1.0 CA B:CYS890 4.2 57.6 1.0 CB B:ARG889 4.3 65.7 1.0 CA B:CYS910 4.3 71.9 1.0 CA B:CYS907 4.3 60.6 1.0 CG1 B:VAL892 4.4 66.5 1.0 NE B:ARG909 4.4 56.1 1.0 CA B:CYS887 4.7 67.9 1.0 C B:ARG889 4.7 66.6 1.0 CZ B:ARG909 4.8 74.0 1.0 N B:ARG889 4.9 68.8 1.0 CA B:ARG889 4.9 65.1 1.0 C B:CYS890 4.9 62.8 1.0 C B:CYS907 4.9 66.9 1.0

A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj. Antibiotic Hyper-Resistance in A Class I Aminoacyl-Trna Synthetase with Altered Active Site Signature Motif To Be Published.