Zinc in PDB 8aow: Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands

The structure of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands also contains other interesting chemical elements:

Magnesium

(Mg)

24 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Zinc atom in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands (pdb code 8aow). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 12 binding sites of Zinc where determined in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands, PDB code: 8aow:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:93.7 occ:1.00 OE2 A:GLU129 1.9 60.7 1.0 SG A:CYS141 2.3 58.7 1.0 NE2 A:HIS79 2.3 42.6 1.0 SG A:CYS134 2.3 68.9 1.0 CB A:CYS141 2.9 45.4 1.0 CD A:GLU129 3.0 61.7 1.0 CE1 A:HIS79 3.2 45.0 1.0 CB A:CYS134 3.3 57.9 1.0 CD2 A:HIS79 3.3 45.2 1.0 OE1 A:GLU129 3.7 61.1 1.0 CA A:CYS141 3.8 47.6 1.0 CG2 A:VAL81 4.1 38.0 1.0 CB A:GLN143 4.2 54.6 1.0 CG A:GLU129 4.2 61.1 1.0 N A:ARG142 4.3 60.4 1.0 ND1 A:HIS79 4.4 44.8 1.0 N A:GLN143 4.4 53.5 1.0 CG A:HIS79 4.4 42.0 1.0 C A:CYS141 4.4 53.4 1.0 ND1 A:HIS136 4.5 52.2 1.0 CG1 A:VAL81 4.5 40.0 1.0 CB A:HIS136 4.6 48.9 1.0 CA A:CYS134 4.7 55.6 1.0 CB A:VAL81 4.8 38.6 1.0 CG A:HIS136 5.0 52.9 1.0 CA A:GLN143 5.0 53.5 1.0 N A:CYS141 5.0 48.2 1.0

Zinc binding site 2 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn602 b:94.4 occ:1.00 OE2 C:GLU129 1.9 62.0 1.0 NE2 C:HIS79 2.3 40.8 1.0 SG C:CYS141 2.3 49.5 1.0 SG C:CYS134 2.3 65.2 1.0 CB C:CYS141 3.0 39.7 1.0 CD C:GLU129 3.1 63.4 1.0 CB C:CYS134 3.2 54.5 1.0 CE1 C:HIS79 3.2 44.6 1.0 CD2 C:HIS79 3.3 44.9 1.0 OE1 C:GLU129 3.8 63.7 1.0 CA C:CYS141 3.8 42.8 1.0 CG2 C:VAL81 4.1 40.0 1.0 CG C:GLU129 4.2 62.2 1.0 CB C:GLN143 4.2 60.0 1.0 N C:ARG142 4.4 62.6 1.0 ND1 C:HIS79 4.4 44.1 1.0 CG C:HIS79 4.4 41.8 1.0 N C:GLN143 4.4 56.4 1.0 CG1 C:VAL81 4.5 42.1 1.0 C C:CYS141 4.5 48.4 1.0 ND1 C:HIS136 4.5 50.2 1.0 CB C:HIS136 4.6 47.1 1.0 CA C:CYS134 4.7 50.6 1.0 CB C:VAL81 4.7 42.9 1.0 CA C:GLN143 5.0 57.9 1.0 CG C:HIS136 5.0 49.0 1.0

Zinc binding site 3 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn602 b:97.6 occ:1.00 OE2 E:GLU129 1.9 57.1 1.0 SG E:CYS134 2.3 65.2 1.0 SG E:CYS141 2.3 48.2 1.0 NE2 E:HIS79 2.3 43.5 1.0 CD E:GLU129 3.0 59.7 1.0 CB E:CYS141 3.1 34.2 1.0 CB E:CYS134 3.2 54.5 1.0 CE1 E:HIS79 3.2 46.1 1.0 CD2 E:HIS79 3.3 44.4 1.0 OE1 E:GLU129 3.6 59.0 1.0 CA E:CYS141 3.8 40.0 1.0 CG2 E:VAL81 4.1 43.4 1.0 CG E:GLU129 4.2 60.1 1.0 CB E:GLN143 4.2 53.2 1.0 ND1 E:HIS79 4.4 44.5 1.0 N E:ARG142 4.4 57.7 1.0 CG E:HIS79 4.4 42.3 1.0 ND1 E:HIS136 4.5 48.0 1.0 N E:GLN143 4.5 54.4 1.0 C E:CYS141 4.6 46.3 1.0 CB E:HIS136 4.6 43.6 1.0 CA E:CYS134 4.6 51.5 1.0 CG1 E:VAL81 4.6 41.2 1.0 CB E:VAL81 4.8 42.1 1.0 CG E:HIS136 4.9 45.9 1.0

Zinc binding site 4 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn602 b:94.4 occ:1.00 OE2 G:GLU129 1.9 63.6 1.0 SG G:CYS134 2.3 68.8 1.0 NE2 G:HIS79 2.3 41.8 1.0 SG G:CYS141 2.3 58.1 1.0 CB G:CYS141 3.0 45.1 1.0 CD G:GLU129 3.0 64.8 1.0 CE1 G:HIS79 3.2 45.3 1.0 CD2 G:HIS79 3.3 44.1 1.0 CB G:CYS134 3.3 57.4 1.0 OE1 G:GLU129 3.6 64.0 1.0 CA G:CYS141 3.7 47.0 1.0 CG2 G:VAL81 4.1 38.3 1.0 N G:ARG142 4.2 63.5 1.0 CB G:GLN143 4.2 54.3 1.0 CG G:GLU129 4.2 64.4 1.0 N G:GLN143 4.4 52.9 1.0 ND1 G:HIS79 4.4 44.1 1.0 C G:CYS141 4.4 53.2 1.0 CG G:HIS79 4.4 41.4 1.0 ND1 G:HIS136 4.5 50.3 1.0 CG1 G:VAL81 4.6 39.8 1.0 CB G:HIS136 4.6 47.8 1.0 CA G:CYS134 4.7 54.8 1.0 CB G:VAL81 4.8 37.7 1.0 CA G:GLN143 4.9 53.0 1.0

Zinc binding site 5 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn602 b:92.0 occ:1.00 OE2 I:GLU129 1.9 61.5 1.0 SG I:CYS134 2.3 63.8 1.0 SG I:CYS141 2.3 52.9 1.0 NE2 I:HIS79 2.3 39.4 1.0 CB I:CYS141 3.0 43.6 1.0 CD I:GLU129 3.1 62.8 1.0 CE1 I:HIS79 3.2 43.8 1.0 CB I:CYS134 3.2 53.5 1.0 CD2 I:HIS79 3.3 44.3 1.0 OE1 I:GLU129 3.7 62.8 1.0 CA I:CYS141 3.8 46.6 1.0 CG2 I:VAL81 4.1 41.7 1.0 CG I:GLU129 4.2 62.4 1.0 CB I:GLN143 4.2 58.0 1.0 N I:ARG142 4.3 63.9 1.0 ND1 I:HIS79 4.4 44.3 1.0 CG I:HIS79 4.4 40.4 1.0 N I:GLN143 4.4 54.4 1.0 ND1 I:HIS136 4.5 49.5 1.0 C I:CYS141 4.5 52.4 1.0 CG1 I:VAL81 4.5 43.0 1.0 CB I:HIS136 4.6 46.3 1.0 CA I:CYS134 4.6 48.9 1.0 CB I:VAL81 4.7 44.9 1.0 CG I:HIS136 5.0 48.2 1.0 CA I:GLN143 5.0 56.1 1.0 CA I:VAL81 5.0 45.5 1.0

Zinc binding site 6 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn602 b:95.6 occ:1.00 OE2 K:GLU129 1.9 55.4 1.0 SG K:CYS134 2.3 62.6 1.0 SG K:CYS141 2.3 47.2 1.0 NE2 K:HIS79 2.3 42.5 1.0 CB K:CYS141 2.9 33.9 1.0 CD K:GLU129 3.0 57.7 1.0 CE1 K:HIS79 3.2 45.8 1.0 CB K:CYS134 3.3 50.7 1.0 CD2 K:HIS79 3.3 44.2 1.0 OE1 K:GLU129 3.6 56.3 1.0 CA K:CYS141 3.8 40.0 1.0 CG2 K:VAL81 4.1 41.4 1.0 CB K:GLN143 4.2 52.7 1.0 CG K:GLU129 4.2 58.3 1.0 N K:ARG142 4.3 52.5 1.0 ND1 K:HIS79 4.3 44.8 1.0 N K:GLN143 4.4 52.3 1.0 C K:CYS141 4.4 44.7 1.0 CG K:HIS79 4.5 43.0 1.0 ND1 K:HIS136 4.5 46.8 1.0 CG1 K:VAL81 4.5 39.0 1.0 CB K:HIS136 4.6 41.6 1.0 CA K:CYS134 4.7 47.7 1.0 CB K:VAL81 4.8 40.1 1.0 CG K:HIS136 4.9 44.0 1.0 CA K:GLN143 5.0 51.8 1.0 N K:CYS141 5.0 37.3 1.0

Zinc binding site 7 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ M:Zn602 b:93.3 occ:1.00 OE2 M:GLU129 1.9 63.6 1.0 SG M:CYS134 2.3 70.2 1.0 SG M:CYS141 2.3 57.7 1.0 NE2 M:HIS79 2.3 41.5 1.0 CD M:GLU129 3.0 64.5 1.0 CB M:CYS141 3.1 47.0 1.0 CB M:CYS134 3.2 58.1 1.0 CE1 M:HIS79 3.2 44.3 1.0 CD2 M:HIS79 3.3 44.4 1.0 OE1 M:GLU129 3.6 64.1 1.0 CA M:CYS141 3.8 49.0 1.0 CG2 M:VAL81 4.1 36.4 1.0 CG M:GLU129 4.2 64.4 1.0 CB M:GLN143 4.2 56.6 1.0 N M:ARG142 4.3 63.7 1.0 ND1 M:HIS79 4.3 44.5 1.0 CG M:HIS79 4.4 41.8 1.0 ND1 M:HIS136 4.4 53.0 1.0 N M:GLN143 4.5 54.6 1.0 C M:CYS141 4.5 54.3 1.0 CG1 M:VAL81 4.5 39.0 1.0 CB M:HIS136 4.6 49.8 1.0 CA M:CYS134 4.6 55.9 1.0 CB M:VAL81 4.8 36.7 1.0 CG M:HIS136 4.9 53.6 1.0

Zinc binding site 8 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ O:Zn602 b:94.6 occ:1.00 OE2 O:GLU129 1.9 63.6 1.0 SG O:CYS141 2.3 54.4 1.0 NE2 O:HIS79 2.3 40.9 1.0 SG O:CYS134 2.3 65.9 1.0 CB O:CYS141 2.9 44.7 1.0 CD O:GLU129 3.1 64.4 1.0 CB O:CYS134 3.2 54.8 1.0 CE1 O:HIS79 3.2 44.1 1.0 CD2 O:HIS79 3.3 46.2 1.0 OE1 O:GLU129 3.7 64.0 1.0 CA O:CYS141 3.7 47.3 1.0 CG2 O:VAL81 3.8 45.5 1.0 CG O:GLU129 4.2 65.3 1.0 CB O:GLN143 4.2 59.2 1.0 ND1 O:HIS79 4.4 45.1 1.0 N O:ARG142 4.4 61.2 1.0 CG O:HIS79 4.4 42.2 1.0 C O:CYS141 4.4 51.9 1.0 N O:GLN143 4.5 54.3 1.0 ND1 O:HIS136 4.5 49.6 1.0 CB O:HIS136 4.6 46.4 1.0 CA O:CYS134 4.6 50.7 1.0 CB O:VAL81 4.9 48.1 1.0 CG O:HIS136 5.0 48.3 1.0 N O:CYS141 5.0 45.8 1.0 CA O:GLN143 5.0 56.9 1.0

Zinc binding site 9 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ Q:Zn602 b:95.2 occ:1.00 OE2 Q:GLU129 1.9 54.6 1.0 SG Q:CYS134 2.3 63.1 1.0 SG Q:CYS141 2.3 50.6 1.0 NE2 Q:HIS79 2.3 42.8 1.0 CB Q:CYS141 2.9 36.5 1.0 CD Q:GLU129 3.0 57.6 1.0 CB Q:CYS134 3.2 50.8 1.0 CE1 Q:HIS79 3.2 45.5 1.0 CD2 Q:HIS79 3.3 44.0 1.0 OE1 Q:GLU129 3.6 56.6 1.0 CA Q:CYS141 3.8 42.3 1.0 CG2 Q:VAL81 4.1 43.1 1.0 CB Q:GLN143 4.2 54.9 1.0 CG Q:GLU129 4.2 57.5 1.0 ND1 Q:HIS79 4.4 44.2 1.0 N Q:ARG142 4.4 57.2 1.0 CG Q:HIS79 4.4 42.7 1.0 N Q:GLN143 4.4 54.7 1.0 C Q:CYS141 4.5 47.2 1.0 ND1 Q:HIS136 4.5 48.0 1.0 CG1 Q:VAL81 4.5 42.0 1.0 CB Q:HIS136 4.6 44.3 1.0 CA Q:CYS134 4.6 47.4 1.0 CB Q:VAL81 4.8 42.5 1.0 CG Q:HIS136 5.0 46.5 1.0 CA Q:GLN143 5.0 54.1 1.0

Zinc binding site 10 out of 12 in the Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Cryoem Structure of the Chikungunya Virus NSP1 Capping Pores in Complex with M7GTP and Sah Ligands within 5.0Å range: probe atom residue distance (Å) B Occ S:Zn602 b:91.2 occ:1.00 OE2 S:GLU129 1.9 64.0 1.0 NE2 S:HIS79 2.3 42.7 1.0 SG S:CYS141 2.3 58.1 1.0 SG S:CYS134 2.3 68.0 1.0 CB S:CYS141 2.9 47.1 1.0 CD S:GLU129 3.1 64.8 1.0 CD2 S:HIS79 3.3 44.9 1.0 CE1 S:HIS79 3.3 45.5 1.0 CB S:CYS134 3.3 57.9 1.0 OE1 S:GLU129 3.7 64.0 1.0 CA S:CYS141 3.7 48.7 1.0 CG2 S:VAL81 4.0 37.1 1.0 CG S:GLU129 4.2 64.1 1.0 CB S:GLN143 4.2 56.8 1.0 N S:ARG142 4.3 61.9 1.0 ND1 S:HIS79 4.4 45.4 1.0 CG S:HIS79 4.4 42.4 1.0 N S:GLN143 4.4 55.3 1.0 C S:CYS141 4.4 54.0 1.0 ND1 S:HIS136 4.5 54.7 1.0 CG1 S:VAL81 4.5 39.9 1.0 CB S:HIS136 4.6 51.2 1.0 CA S:CYS134 4.7 54.9 1.0 CB S:VAL81 4.8 38.9 1.0 CG S:HIS136 5.0 54.5 1.0 N S:CYS141 5.0 48.5 1.0

R.Jones, M.Hons, N.Rabah, N.Zamarreno, R.Arranz, J.Reguera. Structural Basis and Dynamics of Chikungunya Alphavirus Rna Capping By NSP1 Capping Pores. Proc.Natl.Acad.Sci.Usa V. 120 34120 2023.
ISSN: ESSN 1091-6490
PubMed: 36913573
DOI: 10.1073/PNAS.2213934120