Zinc in PDB 7uoe: Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State:
2.7.7.48;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State (pdb code 7uoe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State, PDB code: 7uoe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:73.1 occ:1.00 ND1 A:HIS295 2.2 37.6 1.0 SG A:CYS310 2.3 28.7 1.0 SG A:CYS306 2.3 49.4 1.0 SG A:CYS301 2.3 24.2 1.0 CE1 A:HIS295 3.1 29.4 1.0 CG A:HIS295 3.2 32.8 1.0 O A:CYS306 3.3 44.8 1.0 CB A:CYS301 3.3 29.9 1.0 CB A:CYS310 3.5 22.2 1.0 CB A:HIS295 3.6 25.0 1.0 CA A:CYS301 3.7 28.0 1.0 CB A:CYS306 3.7 22.4 1.0 C A:CYS306 3.8 28.2 1.0 N A:HIS295 4.2 28.3 1.0 NE2 A:HIS295 4.2 27.7 1.0 CA A:CYS306 4.2 23.9 1.0 O A:HOH1193 4.3 36.8 1.0 CD2 A:HIS295 4.3 29.4 1.0 CA A:HIS295 4.5 19.1 1.0 N A:CYS301 4.5 34.7 1.0 N A:ILE307 4.5 31.9 1.0 O A:THR293 4.6 43.7 1.0 CA A:CYS310 4.7 23.9 1.0 N A:CYS310 4.7 36.2 1.0 N A:LEU302 4.8 38.2 1.0 C A:CYS301 4.8 31.8 1.0 CA A:ILE307 4.8 20.1 1.0 ND1 A:HIS309 4.9 32.4 1.0 O A:HIS295 5.0 30.1 1.0

Zinc binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre- Catalytic State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:75.7 occ:1.00 ND1 A:HIS642 2.0 30.6 1.0 SG A:CYS645 2.3 31.5 1.0 SG A:CYS646 2.3 36.7 1.0 SG A:CYS487 2.3 43.3 1.0 CG A:HIS642 3.0 24.1 1.0 CE1 A:HIS642 3.1 26.1 1.0 CB A:HIS642 3.3 28.0 1.0 CB A:CYS646 3.5 31.7 1.0 CB A:CYS645 3.6 34.3 1.0 CB A:CYS487 3.6 40.1 1.0 N A:CYS487 3.6 38.1 1.0 N A:CYS646 3.8 36.5 1.0 CE1 A:PHE571 3.9 32.4 1.0 C A:CYS645 4.1 44.6 1.0 CD2 A:HIS642 4.1 22.6 1.0 CA A:CYS487 4.2 33.9 1.0 NE2 A:HIS642 4.2 26.6 1.0 CA A:CYS646 4.2 29.8 1.0 CA A:HIS642 4.2 31.5 1.0 CA A:CYS645 4.4 42.2 1.0 CD1 A:PHE571 4.5 30.3 1.0 C A:GLY486 4.5 38.2 1.0 NZ A:LYS532 4.6 44.3 1.0 O A:HOH1106 4.6 40.1 1.0 O A:CYS645 4.6 47.7 1.0 CA A:GLY486 4.6 30.1 1.0 CZ A:PHE571 4.7 24.6 1.0 O A:HIS642 4.7 41.4 1.0 CE A:LYS532 4.8 40.4 1.0 C A:HIS642 4.9 35.0 1.0 N A:CYS645 5.0 49.7 1.0

B.F.Malone, S.A.Darst. Sars-Cov-2 Replication-Transcription Complex Bound to Ctp, in A Pre-Catalytic State To Be Published.