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Zinc in PDB 7tsc: Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine
Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine:
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine, PDB code: 7tsc
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 39.53 / 1.80 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 48.904, 114.293, 164.16, 90, 90, 90 |
| R / Rfree (%) | 21.1 / 25.3 |
Other elements in 7tsc:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine also contains other interesting chemical elements:
| Iron | (Fe) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine
(pdb code 7tsc). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine, PDB code: 7tsc:
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine, PDB code: 7tsc:
Zinc binding site 1 out of 1 in 7tsc
Go back to
Zinc Binding Sites List in 7tsc
Zinc binding site 1 out
of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-Methyl-6-(3-(4-Methylpiperazin-1-Yl)Propyl) Pyridin-2-Amine within 5.0Å range:
|
Reference:
D.Vasu,
H.Li,
C.D.Hardy,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Shortened Amino Sidechain As Potent, Selective, and Highly Permeable Human Neuronal Nitric Oxide Synthase Inhibitors. Bioorg.Med.Chem. V. 69 16878 2022.
ISSN: ESSN 1464-3391
PubMed: 35772285
DOI: 10.1016/J.BMC.2022.116878
Page generated: Wed Oct 30 11:45:24 2024
ISSN: ESSN 1464-3391
PubMed: 35772285
DOI: 10.1016/J.BMC.2022.116878
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