Zinc in PDB 7riy: Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Enzymatic activity of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
All present enzymatic activity of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp:
2.7.7.6;
2.7.7.6;
Protein crystallography data
The structure of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp, PDB code: 7riy
was solved by
J.Oh,
P.B.Dervan,
D.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.53 / 3.70 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 167.775, 222.76, 192.956, 90, 100.54, 90 |
| R / Rfree (%) | 23.2 / 28.1 |
Other elements in 7riy:
The structure of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
(pdb code 7riy). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp, PDB code: 7riy:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Zinc where determined in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp, PDB code: 7riy:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Zinc binding site 1 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 1 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 2 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 2 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 3 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 3 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 4 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 4 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 5 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 5 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 6 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 6 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 7 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 7 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Zinc binding site 8 out of 8 in 7riy
Go back to
Zinc Binding Sites List in 7riy
Zinc binding site 8 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 2 Soaked with Utp within 5.0Å range:
|
Reference:
J.Oh,
T.Jia,
J.Xu,
J.Chong,
P.B.Dervan,
D.Wang.
Rna Polymerase II Trapped on A Molecular Treadmill: Structural Basis of Persistent Transcriptional Arrest By A Minor Groove Dna Binder. Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
PubMed: 35022237
DOI: 10.1073/PNAS.2114065119
Page generated: Wed Oct 30 10:22:50 2024
ISSN: ESSN 1091-6490
PubMed: 35022237
DOI: 10.1073/PNAS.2114065119
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