Zinc in PDB 7rip: Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Enzymatic activity of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
All present enzymatic activity of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp:
2.7.7.6;
2.7.7.6;
Protein crystallography data
The structure of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp, PDB code: 7rip
was solved by
J.Oh,
P.B.Dervan,
D.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.23 / 3.30 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 168.158, 223.041, 193.464, 90, 100.67, 90 |
| R / Rfree (%) | 21.9 / 26.1 |
Other elements in 7rip:
The structure of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
(pdb code 7rip). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp, PDB code: 7rip:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Zinc where determined in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp, PDB code: 7rip:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Zinc binding site 1 out of 8 in 7rip
Go back to
Zinc Binding Sites List in 7rip
Zinc binding site 1 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 2 out of 8 in 7rip
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Zinc Binding Sites List in 7rip
Zinc binding site 2 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 3 out of 8 in 7rip
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Zinc Binding Sites List in 7rip
Zinc binding site 3 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 4 out of 8 in 7rip
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Zinc Binding Sites List in 7rip
Zinc binding site 4 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 5 out of 8 in 7rip
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Zinc Binding Sites List in 7rip
Zinc binding site 5 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 6 out of 8 in 7rip
Go back to
Zinc Binding Sites List in 7rip
Zinc binding site 6 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 7 out of 8 in 7rip
Go back to
Zinc Binding Sites List in 7rip
Zinc binding site 7 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Zinc binding site 8 out of 8 in 7rip
Go back to
Zinc Binding Sites List in 7rip
Zinc binding site 8 out
of 8 in the Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Rna Polymerase II Elongation Complex with Hairpin Polyamide Py-Im 1, Scaffold 1 Soaked with Ctp within 5.0Å range:
|
Reference:
J.Oh,
T.Jia,
J.Xu,
J.Chong,
P.B.Dervan,
D.Wang.
Rna Polymerase II Trapped on A Molecular Treadmill: Structural Basis of Persistent Transcriptional Arrest By A Minor Groove Dna Binder. Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
PubMed: 35022237
DOI: 10.1073/PNAS.2114065119
Page generated: Wed Oct 30 10:22:09 2024
ISSN: ESSN 1091-6490
PubMed: 35022237
DOI: 10.1073/PNAS.2114065119
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