Zinc in PDB 7r47: Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map)

All present enzymatic activity of Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map):
1.6.5.3; 1.6.99.3; 7.1.1.2;

The structure of Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map) also contains other interesting chemical elements:

Iodine	(I)	2 atoms
Potassium	(K)	1 atom
Magnesium	(Mg)	1 atom
Chlorine	(Cl)	2 atoms
Iron	(Fe)	28 atoms

The binding sites of Zinc atom in the Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map) (pdb code 7r47). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map), PDB code: 7r47:

Zinc binding site 1 out of 1 in the Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Complex I in the Presence of IM1761092, Deactive Class III (Composite Map) within 5.0Å range: probe atom residue distance (Å) B Occ R:Zn201 b:45.4 occ:1.00 NE2 R:HIS68 2.0 26.1 1.0 SG R:CYS84 2.2 30.1 1.0 SG R:CYS87 2.3 29.2 1.0 SG R:CYS59 2.3 29.9 1.0 CE1 R:HIS68 2.8 26.1 1.0 CD2 R:HIS68 3.1 26.1 1.0 CB R:CYS84 3.2 30.1 1.0 CB R:CYS87 3.4 29.2 1.0 CB R:CYS59 3.4 29.9 1.0 N R:GLY61 3.7 28.9 1.0 N R:CYS87 3.8 29.2 1.0 CA R:GLY61 3.8 28.9 1.0 ND1 R:HIS68 4.0 26.1 1.0 CA R:CYS87 4.1 29.2 1.0 CG R:HIS68 4.2 26.1 1.0 C R:CYS59 4.4 29.9 1.0 CB R:TYR86 4.5 25.3 1.0 C R:ASP60 4.5 28.9 1.0 CA R:CYS59 4.6 29.9 1.0 O R:CYS59 4.6 29.9 1.0 CA R:CYS84 4.7 30.1 1.0 N R:ASP60 4.7 28.9 1.0 C R:TYR86 4.8 25.3 1.0 C R:CYS87 4.8 29.2 1.0 N R:GLY88 5.0 30.7 1.0 N R:TYR86 5.0 25.3 1.0 CA R:TYR86 5.0 25.3 1.0 CA R:ASP60 5.0 28.9 1.0

H.R.Bridges, J.N.Blaza, Z.Yin, I.Chung, M.N.Pollak, J.Hirst. Structural Basis of Mammalian Respiratory Complex I Inhibition By Medicinal Biguanides. Science V. 379 351 2023.
ISSN: ESSN 1095-9203
PubMed: 36701435
DOI: 10.1126/SCIENCE.ADE3332