Zinc in PDB 7p4o: Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc

Enzymatic activity of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc

All present enzymatic activity of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc:
3.1.4.39;

Protein crystallography data

The structure of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc, PDB code: 7p4o was solved by M.C.Eymery, A.A.Mccarthy, J.Hausmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.29 / 1.69
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 53.841, 62.361, 64.356, 103.7, 98.37, 93.44
R / Rfree (%) 17.1 / 20.6

Other elements in 7p4o:

The structure of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Iodine (I) 12 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc (pdb code 7p4o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc, PDB code: 7p4o:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7p4o

Go back to Zinc Binding Sites List in 7p4o
Zinc binding site 1 out of 2 in the Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn902

b:22.1
occ:0.92
NE2 A:HIS315 2.0 19.1 1.0
NE2 A:HIS474 2.0 16.6 1.0
OD1 A:ASP311 2.3 26.0 1.0
O A:HOH1010 2.4 28.9 1.0
OD2 A:ASP311 2.4 24.0 1.0
O A:HOH1363 2.6 34.6 1.0
CG A:ASP311 2.7 22.6 1.0
CD2 A:HIS315 3.0 20.6 1.0
CE1 A:HIS474 3.0 19.6 1.0
CE1 A:HIS315 3.0 21.0 1.0
CD2 A:HIS474 3.0 19.2 1.0
O A:HOH1083 4.0 22.3 1.0
CE1 A:HIS359 4.1 19.2 1.0
ND1 A:HIS474 4.1 16.9 1.0
ND1 A:HIS315 4.1 22.1 1.0
CG A:HIS315 4.1 18.3 1.0
CG A:HIS474 4.2 15.1 1.0
CB A:ASP311 4.2 22.7 1.0
O A:HOH1060 4.3 41.4 1.0
NE2 A:HIS359 4.3 18.8 1.0
CE A:MET361 4.4 18.3 1.0
O A:HOH1024 4.5 39.4 1.0
OD1 A:ASP171 4.6 27.4 1.0
ZN A:ZN903 4.6 15.9 0.4
OG1 A:THR209 4.6 19.8 1.0
O A:ASP311 4.9 22.8 1.0

Zinc binding site 2 out of 2 in 7p4o

Go back to Zinc Binding Sites List in 7p4o
Zinc binding site 2 out of 2 in the Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Autotaxin and 9(R)-DELTA6A,10A-Thc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn903

b:15.9
occ:0.42
OD1 A:ASP171 1.8 27.4 1.0
OG1 A:THR209 2.0 19.8 1.0
NE2 A:HIS359 2.0 18.8 1.0
OD2 A:ASP358 2.1 23.9 1.0
O A:HOH1010 2.5 28.9 1.0
CG A:ASP171 2.6 33.6 1.0
CD2 A:HIS359 2.8 19.5 1.0
OD2 A:ASP171 2.9 35.5 1.0
CG A:ASP358 3.0 20.1 1.0
CB A:THR209 3.0 17.7 1.0
CE1 A:HIS359 3.1 19.2 1.0
OD1 A:ASP358 3.3 20.0 1.0
CA A:THR209 3.4 17.1 1.0
CG2 A:THR209 3.4 23.1 1.0
H A:GLY172 3.6 23.4 1.0
N A:THR209 3.9 14.1 1.0
CB A:ASP171 4.0 25.9 1.0
CG A:HIS359 4.0 15.9 1.0
ND1 A:HIS359 4.0 15.9 1.0
O A:HOH1060 4.1 41.4 1.0
N A:GLY172 4.1 19.4 1.0
O A:HOH1083 4.1 22.3 1.0
OD1 A:ASP311 4.3 26.0 1.0
CA A:ASP171 4.3 21.2 1.0
CE1 A:HIS474 4.3 19.6 1.0
CB A:ASP358 4.3 14.3 1.0
CG A:ASP311 4.5 22.6 1.0
ZN A:ZN902 4.6 22.1 0.9
C A:ASP171 4.6 22.2 1.0
NE2 A:HIS474 4.7 16.6 1.0
C A:LYS208 4.7 16.7 1.0
HA2 A:GLY172 4.8 22.7 1.0
C A:THR209 4.8 15.5 1.0
OD2 A:ASP311 4.8 24.0 1.0
CA A:GLY172 4.9 18.9 1.0
HA3 A:GLY172 5.0 22.7 1.0
CB A:ASP311 5.0 22.7 1.0

Reference:

M.C.Eymery, A.A.Andrew, J.Hausmann. Linking the Endocannabinoid System and Medicinal Cannabis to Autotaxin-Lysophosphatic Acid Signaling To Be Published.
Page generated: Sat Apr 8 01:18:34 2023

Last articles

Cd in 2W5E
Cd in 2W5F
Cd in 2W2C
Cd in 2VZO
Cd in 2W0O
Cd in 2VZU
Cd in 2VZT
Cd in 2VZS
Cd in 2V2S
Cd in 2V4B
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy