Zinc in PDB 7nic: Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)

Enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)

All present enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class):
3.6.4.13;

Other elements in 7nic:

The structure of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Aluminium (Al) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) (pdb code 7nic). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class), PDB code: 7nic:

Zinc binding site 1 out of 1 in 7nic

Go back to Zinc Binding Sites List in 7nic
Zinc binding site 1 out of 1 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1103

b:199.2
occ:1.00
HG A:CYS962 1.2 161.7 1.0
HB3 A:CYS964 2.3 164.8 1.0
SG A:CYS907 2.3 144.4 1.0
SG A:CYS910 2.3 149.6 1.0
SG A:CYS964 2.3 164.8 1.0
SG A:CYS962 2.3 161.7 1.0
CB A:CYS964 2.8 164.8 1.0
H A:CYS910 3.0 149.6 1.0
HB3 A:GLN966 3.0 151.9 1.0
H A:CYS964 3.0 164.8 1.0
HB3 A:CYS907 3.2 144.4 1.0
HE2 A:MET912 3.2 147.2 1.0
CB A:CYS907 3.2 144.4 1.0
HB2 A:CYS907 3.4 144.4 1.0
CB A:CYS962 3.4 161.7 1.0
HB3 A:CYS962 3.4 161.7 1.0
HB2 A:CYS962 3.4 161.7 1.0
HB2 A:GLN966 3.5 151.9 1.0
HB3 A:CYS910 3.5 149.6 1.0
HB2 A:CYS964 3.5 164.8 1.0
H A:GLN966 3.5 151.9 1.0
CB A:CYS910 3.5 149.6 1.0
CB A:GLN966 3.7 151.9 1.0
HB3 A:ASN909 3.7 150.1 1.0
HE1 A:TRP968 3.7 142.6 1.0
N A:CYS964 3.7 164.8 1.0
N A:CYS910 3.7 149.6 1.0
HZ2 A:TRP968 3.8 142.6 1.0
CA A:CYS964 3.8 164.8 1.0
CE A:MET912 4.0 147.2 1.0
HB3 A:MET912 4.1 147.2 1.0
CA A:CYS910 4.1 149.6 1.0
HE1 A:MET912 4.2 147.2 1.0
O A:CYS910 4.2 149.6 1.0
N A:GLN966 4.3 151.9 1.0
HB2 A:CYS910 4.3 149.6 1.0
H A:GLY965 4.4 158.6 1.0
HE3 A:MET912 4.4 147.2 1.0
NE1 A:TRP968 4.4 142.6 1.0
H A:LYS963 4.5 156.3 1.0
HG2 A:GLN966 4.5 151.9 1.0
CZ2 A:TRP968 4.6 142.6 1.0
HA A:CYS964 4.6 164.8 1.0
C A:CYS910 4.6 149.6 1.0
C A:CYS964 4.6 164.8 1.0
H A:ASN909 4.6 150.1 1.0
CA A:GLN966 4.6 151.9 1.0
N A:GLY965 4.7 158.6 1.0
H A:LYS908 4.7 139.5 1.0
CB A:ASN909 4.7 150.1 1.0
CA A:CYS907 4.7 144.4 1.0
CG A:GLN966 4.7 151.9 1.0
HB2 A:MET912 4.7 147.2 1.0
H A:MET912 4.8 147.2 1.0
CA A:CYS962 4.8 161.7 1.0
N A:LYS963 4.9 156.3 1.0
CE2 A:TRP968 4.9 142.6 1.0
C A:ASN909 4.9 150.1 1.0
CB A:MET912 4.9 147.2 1.0
HD21 A:ASN909 4.9 150.1 1.0
C A:LYS963 5.0 156.3 1.0

Reference:

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5
Page generated: Thu Nov 25 10:56:57 2021

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