Zinc in PDB 7k7t: Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp

The structure of Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp, PDB code: 7k7t was solved by B.J.Klein, A.H.Tencer, T.G.Kutateladze, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.11 / 2.94
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	52.424, 109.934, 70.390, 90.00, 95.95, 90.00
R / Rfree (%)	23.7 / 26.4

The structure of Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp (pdb code 7k7t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp, PDB code: 7k7t:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:41.9 occ:1.00 CB A:CYS432 1.9 35.7 1.0 SG A:CYS453 2.3 44.5 1.0 SG A:CYS464 2.3 41.2 1.0 SG A:CYS429 2.3 34.0 1.0 SG A:CYS432 2.4 36.8 1.0 CB A:CYS429 3.1 36.4 1.0 CB A:CYS464 3.2 43.9 1.0 CB A:CYS453 3.2 47.3 1.0 CA A:CYS432 3.4 37.4 1.0 CA A:CYS464 3.6 45.9 1.0 N A:CYS432 3.9 35.6 1.0 N A:CYS453 3.9 45.2 1.0 CA A:CYS453 4.2 49.9 1.0 C A:CYS432 4.3 37.4 1.0 N A:CYS464 4.5 50.2 1.0 O A:CYS464 4.5 45.1 1.0 CA A:CYS429 4.6 36.4 1.0 C A:CYS464 4.6 45.8 1.0 N A:LEU433 4.8 35.4 1.0 O A:CYS432 4.9 37.5 1.0 C A:GLU431 4.9 34.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human MORC4 Atpase-Cw in Complex with Amppnp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:67.5 occ:1.00 CB B:CYS432 1.9 57.6 1.0 SG B:CYS453 2.3 68.6 1.0 SG B:CYS464 2.3 79.7 1.0 SG B:CYS429 2.3 59.1 1.0 SG B:CYS432 2.4 58.8 1.0 CB B:CYS429 3.1 53.9 1.0 CB B:CYS464 3.4 71.6 1.0 CA B:CYS432 3.4 57.2 1.0 CB B:CYS453 3.4 75.7 1.0 CA B:CYS464 3.7 71.0 1.0 N B:CYS432 3.9 62.4 1.0 N B:CYS453 4.2 77.7 1.0 C B:CYS432 4.3 53.4 1.0 CA B:CYS453 4.4 71.1 1.0 N B:CYS464 4.5 71.8 1.0 CA B:CYS429 4.6 50.4 1.0 N B:LEU433 4.7 52.4 1.0 C B:CYS464 4.8 70.9 1.0 NH2 B:ARG436 4.8 65.1 1.0 O B:CYS464 4.9 69.5 1.0 C B:GLU431 4.9 63.8 1.0 O B:CYS432 5.0 56.1 1.0

A.H.Tencer, K.L.Cox, G.M.Wright, Y.Zhang, C.J.Petell, B.J.Klein, B.D.Strahl, J.C.Black, M.G.Poirier, T.G.Kutateladze. Molecular Mechanism of the MORC4 Atpase Activation. Nat Commun V. 11 5466 2020.
ISSN: ESSN 2041-1723
PubMed: 33122719
DOI: 10.1038/S41467-020-19278-8