Zinc in PDB 7k36: Cryo-Em Structure of Stripak Complex

All present enzymatic activity of Cryo-Em Structure of Stripak Complex:
3.1.3.16;

The structure of Cryo-Em Structure of Stripak Complex also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Cryo-Em Structure of Stripak Complex (pdb code 7k36). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Stripak Complex, PDB code: 7k36:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Stripak Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Stripak Complex within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn301 b:166.3 occ:1.00 ND1 H:HIS127 2.0 147.4 1.0 NE2 H:HIS113 2.0 141.5 1.0 SG H:CYS110 2.2 140.3 1.0 SG H:CYS119 2.3 145.4 1.0 CG H:HIS127 2.4 147.4 1.0 CB H:HIS127 2.4 147.4 1.0 CD2 H:HIS113 2.7 141.5 1.0 CB H:CYS110 2.9 140.3 1.0 CE1 H:HIS113 3.1 141.5 1.0 CE1 H:HIS127 3.2 147.4 1.0 CB H:CYS119 3.5 145.4 1.0 O H:ASP123 3.6 146.3 1.0 CD2 H:HIS127 3.6 147.4 1.0 CG H:HIS113 3.9 141.5 1.0 CA H:HIS127 3.9 147.4 1.0 NE2 H:HIS127 4.0 147.4 1.0 ND1 H:HIS113 4.0 141.5 1.0 CA H:TYR124 4.2 142.1 1.0 C H:ASP123 4.3 146.3 1.0 CA H:CYS110 4.4 140.3 1.0 N H:HIS127 4.5 147.4 1.0 N H:TYR124 4.5 142.1 1.0 O H:TYR124 4.6 142.1 1.0 CB H:ALA112 4.6 143.8 1.0 C H:HIS127 4.7 147.4 1.0 N H:HIS113 4.7 141.5 1.0 C H:TYR124 4.8 142.1 1.0 CA H:CYS119 4.8 145.4 1.0 N H:ALA112 4.8 143.8 1.0 O H:CYS119 4.9 145.4 1.0 C H:CYS110 4.9 140.3 1.0 N H:THR128 4.9 141.8 1.0 N H:ALA111 5.0 139.2 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Stripak Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Stripak Complex within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn302 b:188.8 occ:1.00 NE2 H:HIS169 2.0 154.8 1.0 NE2 H:HIS174 2.1 159.9 1.0 SG H:CYS97 2.3 170.8 1.0 SG H:CYS92 2.4 171.1 1.0 CE1 H:HIS169 2.9 154.8 1.0 CD2 H:HIS174 2.9 159.9 1.0 CD2 H:HIS169 3.0 154.8 1.0 CE1 H:HIS174 3.0 159.9 1.0 CB H:CYS97 3.3 170.8 1.0 CD1 H:LEU88 3.6 158.0 1.0 CB H:CYS92 3.7 171.1 1.0 CD2 H:LEU88 3.8 158.0 1.0 CG H:LEU88 4.0 158.0 1.0 ND1 H:HIS169 4.0 154.8 1.0 CG H:HIS174 4.0 159.9 1.0 ND1 H:HIS174 4.1 159.9 1.0 CA H:CYS92 4.1 171.1 1.0 CG H:HIS169 4.1 154.8 1.0 CB H:ALA121 4.2 143.3 1.0 CA H:CYS97 4.4 170.8 1.0 CB H:HIS173 4.6 156.5 1.0 C H:CYS92 4.7 171.1 1.0 O H:CYS92 4.9 171.1 1.0

B.C.Jeong, S.J.Bae, L.Ni, X.Zhang, X.C.Bai, X.Luo. Cryo-Em Structure of the Hippo Signaling Integrator Human Stripak. Nat.Struct.Mol.Biol. 2021.
ISSN: ESSN 1545-9985
PubMed: 33633399
DOI: 10.1038/S41594-021-00564-Y