Zinc in PDB 7jn3: Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048

All present enzymatic activity of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048:
2.7.7.49; 2.7.7.7; 3.1.26.4;

The structure of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 also contains other interesting chemical elements:

Fluorine	(F)	2 atoms
Magnesium	(Mg)	4 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Zinc atom in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 (pdb code 7jn3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048, PDB code: 7jn3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:106.4 occ:1.00 ND1 A:HIS13 2.1 56.2 1.0 NE2 A:HIS9 2.1 61.0 1.0 SG A:CYS40 2.3 74.7 1.0 SG A:CYS37 2.3 75.6 1.0 CB A:CYS37 2.5 75.6 1.0 CE1 A:HIS13 2.6 56.2 1.0 CD2 A:HIS9 3.0 61.0 1.0 CE1 A:HIS9 3.1 61.0 1.0 CG A:HIS13 3.3 56.2 1.0 CB A:CYS40 3.7 74.7 1.0 NE2 A:HIS13 3.9 56.2 1.0 CA A:CYS37 4.0 75.6 1.0 CB A:HIS13 4.0 56.2 1.0 CG A:HIS9 4.1 61.0 1.0 ND1 A:HIS9 4.1 61.0 1.0 N A:CYS40 4.2 74.7 1.0 CD2 A:HIS13 4.2 56.2 1.0 CA A:HIS13 4.3 56.2 1.0 CA A:CYS40 4.5 74.7 1.0 O A:CYS37 4.6 75.6 1.0 C A:CYS37 4.6 75.6 1.0 N A:CYS37 4.7 75.6 1.0 O A:HIS9 4.8 61.0 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn301 b:80.9 occ:1.00 ND1 E:HIS13 2.1 51.9 1.0 NE2 E:HIS9 2.1 60.3 1.0 SG E:CYS40 2.3 66.3 1.0 SG E:CYS37 2.3 67.7 1.0 CB E:CYS37 2.5 67.7 1.0 CE1 E:HIS13 2.5 51.9 1.0 CD2 E:HIS9 2.9 60.3 1.0 CE1 E:HIS9 3.1 60.3 1.0 CG E:HIS13 3.4 51.9 1.0 CB E:CYS40 3.7 66.3 1.0 NE2 E:HIS13 3.8 51.9 1.0 CA E:CYS37 4.0 67.7 1.0 CB E:HIS13 4.1 51.9 1.0 CG E:HIS9 4.1 60.3 1.0 ND1 E:HIS9 4.1 60.3 1.0 N E:CYS40 4.2 66.3 1.0 CD2 E:HIS13 4.2 51.9 1.0 CA E:HIS13 4.3 51.9 1.0 CA E:CYS40 4.4 66.3 1.0 O E:CYS37 4.5 67.7 1.0 C E:CYS37 4.5 67.7 1.0 N E:CYS37 4.7 67.7 1.0 O E:HIS9 4.8 60.3 1.0

K.K.Pandey, S.Bera, K.Shi, H.Aihara, D.P.Grandgenett, M.J.Rau, A.V.Oleru, J.A.J.Fitzpatrick, A.N.Engelman. Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 Commun Biol 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-01855-2