Zinc in PDB 7jm5: Crystal Structure of KDM4B in Complex with QC6352

All present enzymatic activity of Crystal Structure of KDM4B in Complex with QC6352:
1.14.11.66;

The structure of Crystal Structure of KDM4B in Complex with QC6352, PDB code: 7jm5 was solved by S.W.White, M.Yun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.03 / 2.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	59.825, 97.107, 80.068, 90, 106.52, 90
R / Rfree (%)	19.6 / 24.4

The structure of Crystal Structure of KDM4B in Complex with QC6352 also contains other interesting chemical elements:

Nickel

(Ni)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of KDM4B in Complex with QC6352 (pdb code 7jm5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of KDM4B in Complex with QC6352, PDB code: 7jm5:

Zinc binding site 1 out of 1 in the Crystal Structure of KDM4B in Complex with QC6352


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of KDM4B in Complex with QC6352 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:122.0 occ:1.00 NE2 B:HIS241 2.0 156.3 1.0 CD2 B:HIS241 2.9 149.2 1.0 CE1 B:HIS241 3.1 153.3 1.0 CG B:HIS241 4.1 144.6 1.0 ND1 B:HIS241 4.1 150.7 1.0 CA B:PHE238 4.8 125.1 1.0

S.Singh, A.Abu-Zaid, H.Jin, J.Fang, Q.Wu, T.Wang, H.Feng, W.Quarni, Y.Shao, L.Maxham, A.Abdolvahabi, M.K.Yun, S.Vaithiyalingam, H.Tan, J.Bowling, V.Honnell, B.Young, Y.Guo, R.Bajpai, S.M.Pruett-Miller, G.C.Grosveld, M.Hatley, B.Xu, Y.Fan, G.Wu, E.Y.Chen, T.Chen, P.W.Lewis, Z.Rankovic, Y.Li, A.J.Murphy, J.Easton, J.Peng, X.Chen, R.Wang, S.W.White, A.M.Davidoff, J.Yang. Targeting KDM4 For Treating PAX3-FOXO1-Driven Alveolar Rhabdomyosarcoma. Sci Transl Med V. 14 Q2096 2022.
ISSN: ESSN 1946-6242
PubMed: 35857643
DOI: 10.1126/SCITRANSLMED.ABQ2096