Zinc in PDB 7ea8: Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations

All present enzymatic activity of Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations:
2.1.1.359;

The binding sites of Zinc atom in the Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations (pdb code 7ea8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations, PDB code: 7ea8:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn1801 b:42.6 occ:1.00 SG L:CYS1539 2.6 47.8 1.0 SG L:CYS1516 2.6 45.7 1.0 SG L:CYS1533 2.6 53.0 1.0 SG L:CYS1529 2.8 46.9 1.0 ZN L:ZN1802 3.3 51.8 1.0 OD1 L:ASN1541 3.5 48.3 1.0 SG L:CYS1499 3.6 47.2 1.0 CB L:CYS1539 3.7 47.8 1.0 CB L:CYS1516 3.7 45.7 1.0 CB L:CYS1529 3.8 46.9 1.0 CB L:CYS1533 4.0 53.0 1.0 ND2 L:ASN1535 4.2 53.0 1.0 CG L:ASN1541 4.5 48.3 1.0 SG L:CYS1520 4.7 43.6 1.0 CB L:CYS1499 4.7 47.2 1.0 CA L:CYS1539 4.8 47.8 1.0 CB L:ASN1541 5.0 48.3 1.0

Zinc binding site 2 out of 3 in the Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn1802 b:51.8 occ:1.00 SG L:CYS1520 2.5 43.6 1.0 SG L:CYS1499 2.6 47.2 1.0 SG L:CYS1516 2.6 45.7 1.0 SG L:CYS1501 2.8 51.5 1.0 CB L:CYS1499 3.0 47.2 1.0 ZN L:ZN1801 3.3 42.6 1.0 CB L:CYS1520 3.5 43.6 1.0 CB L:CYS1516 3.6 45.7 1.0 CB L:CYS1501 4.2 51.5 1.0 CA L:CYS1516 4.3 45.7 1.0 CA L:CYS1520 4.4 43.6 1.0 OD1 L:ASN1541 4.4 48.3 1.0 CA L:CYS1499 4.5 47.2 1.0 SG L:CYS1529 4.7 46.9 1.0 ND2 L:ASN1535 4.8 53.0 1.0 N L:LEU1521 4.9 38.0 1.0

Zinc binding site 3 out of 3 in the Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human SETD2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn1803 b:75.3 occ:1.00 SG L:CYS1678 2.7 67.6 1.0 CB L:CYS1678 2.7 67.6 1.0 SG L:CYS1685 2.8 57.1 1.0 SG L:CYS1680 3.1 56.4 1.0 SG L:CYS1631 3.3 60.1 1.0 CD2 L:HIS1629 3.8 62.7 1.0 N L:CYS1631 3.9 60.1 1.0 CB L:CYS1685 4.1 57.1 1.0 NE2 L:HIS1629 4.1 62.7 1.0 CA L:CYS1678 4.2 67.6 1.0 CA L:SER1630 4.3 59.1 1.0 CB L:CYS1631 4.3 60.1 1.0 C L:SER1630 4.4 59.1 1.0 CB L:CYS1680 4.5 56.4 1.0 C L:CYS1678 4.6 67.6 1.0 N L:GLY1687 4.6 59.6 1.0 CA L:CYS1685 4.6 57.1 1.0 CA L:CYS1631 4.6 60.1 1.0 O L:HIS1629 4.8 62.7 1.0 CA L:GLY1687 4.8 59.6 1.0 N L:CYS1680 4.8 56.4 1.0 N L:CYS1678 4.9 67.6 1.0 N L:SER1630 4.9 59.1 1.0 O L:CYS1678 5.0 67.6 1.0 CG L:HIS1629 5.0 62.7 1.0 N L:PHE1679 5.0 63.3 1.0

Y.Liu, Y.Zhang, H.Xue, M.Cao, G.Bai, Z.Mu, Y.Yao, S.Sun, D.Fang, J.Huang. Cryo-Em Structure of SETD2/SET2 Methyltransferase Bound to A Nucleosome Containing Oncohistone Mutations. Cell Discov V. 7 32 2021.
ISSN: ESSN 2056-5968
PubMed: 33972509
DOI: 10.1038/S41421-021-00261-6