Zinc in PDB 7c2k: Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex

All present enzymatic activity of Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex:
2.7.7.48;

The binding sites of Zinc atom in the Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex (pdb code 7c2k). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex, PDB code: 7c2k:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:53.2 occ:1.00 ND1 A:HIS295 2.6 26.9 1.0 CB A:CYS306 2.8 31.6 1.0 SG A:CYS310 2.8 27.1 1.0 CE1 A:HIS295 3.0 26.9 1.0 SG A:CYS306 3.2 31.6 1.0 SG A:CYS301 3.3 30.7 1.0 O A:CYS306 3.4 31.6 1.0 CA A:CYS306 3.5 31.6 1.0 C A:CYS306 3.6 31.6 1.0 CB A:CYS301 3.7 30.7 1.0 CG A:HIS295 3.9 26.9 1.0 CA A:CYS301 3.9 30.7 1.0 NE2 A:HIS295 4.3 26.9 1.0 N A:LEU302 4.4 30.4 1.0 CB A:CYS310 4.4 27.1 1.0 O A:THR293 4.4 30.3 1.0 CB A:HIS295 4.6 26.9 1.0 N A:ILE307 4.6 27.5 1.0 C A:CYS301 4.7 30.7 1.0 CD2 A:HIS295 4.7 26.9 1.0 N A:HIS295 4.9 26.9 1.0 N A:CYS306 4.9 31.6 1.0 ND1 A:HIS309 4.9 26.8 1.0 CG A:LEU302 5.0 30.4 1.0

Zinc binding site 2 out of 2 in the Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Covid-19 Rna-Dependent Rna Polymerase Pre-Translocated Catalytic Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:46.6 occ:1.00 ND1 A:HIS642 2.6 30.9 1.0 SG A:CYS646 2.8 34.5 1.0 SG A:CYS487 2.8 31.1 1.0 SG A:CYS645 2.9 36.1 1.0 CB A:HIS642 3.0 30.9 1.0 CG A:HIS642 3.1 30.9 1.0 CB A:CYS646 3.3 34.5 1.0 CE1 A:HIS642 3.7 30.9 1.0 CE1 A:PHE571 3.7 28.7 1.0 N A:CYS646 4.0 34.5 1.0 CB A:CYS487 4.1 31.1 1.0 CB A:CYS645 4.2 36.1 1.0 CA A:HIS642 4.2 30.9 1.0 CA A:CYS646 4.3 34.5 1.0 CD2 A:HIS642 4.3 30.9 1.0 CD1 A:PHE571 4.3 28.7 1.0 C A:CYS645 4.4 36.1 1.0 N A:CYS487 4.5 31.1 1.0 NE2 A:HIS642 4.6 30.9 1.0 CZ A:PHE571 4.6 28.7 1.0 O A:CYS645 4.8 36.1 1.0 O A:HIS642 4.8 30.9 1.0 CA A:CYS645 4.9 36.1 1.0 CA A:CYS487 4.9 31.1 1.0 C A:HIS642 4.9 30.9 1.0 NZ A:LYS532 4.9 29.0 1.0

Q.Wang, J.Wu, H.Wang, Y.Gao, Q.Liu, A.Mu, W.Ji, L.Yan, Y.Zhu, C.Zhu, X.Fang, H.Yang, Y.Huang, H.Gao, F.Liu, J.Ge, Q.Sun, X.Yang, W.Xu, Z.Liu, H.Yang, Z.Lou, B.Jiang, L.W.Guddat, P.Gong, Z.Rao. Structural Basis For Rna Replication By the Sars-Cov-2 Polymerase Cell(Cambridge,Mass.) 2020.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2020.05.034