Zinc in PDB 7av0: LTA4 Hydrolase in Complex with Compound R(13)

Enzymatic activity of LTA4 Hydrolase in Complex with Compound R(13)

All present enzymatic activity of LTA4 Hydrolase in Complex with Compound R(13):
3.3.2.6;

Protein crystallography data

The structure of LTA4 Hydrolase in Complex with Compound R(13), PDB code: 7av0 was solved by H.Srinivas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.82 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.151, 87.057, 99.611, 90, 90, 90
R / Rfree (%) 15.5 / 19.4

Other elements in 7av0:

The structure of LTA4 Hydrolase in Complex with Compound R(13) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Ytterbium (Yb) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the LTA4 Hydrolase in Complex with Compound R(13) (pdb code 7av0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the LTA4 Hydrolase in Complex with Compound R(13), PDB code: 7av0:

Zinc binding site 1 out of 1 in 7av0

Go back to Zinc Binding Sites List in 7av0
Zinc binding site 1 out of 1 in the LTA4 Hydrolase in Complex with Compound R(13)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of LTA4 Hydrolase in Complex with Compound R(13) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:31.9
occ:1.00
OE1 A:GLU318 2.0 23.6 1.0
NE2 A:HIS295 2.1 16.8 1.0
NE2 A:HIS299 2.1 15.9 1.0
O25 A:RZB708 2.4 28.8 1.0
CD A:GLU318 2.6 29.0 1.0
OE2 A:GLU318 2.6 21.6 1.0
C24 A:RZB708 2.8 29.8 1.0
O26 A:RZB708 2.9 35.0 1.0
CD2 A:HIS295 2.9 16.9 1.0
CE1 A:HIS299 3.1 15.4 1.0
CD2 A:HIS299 3.2 15.4 1.0
CE1 A:HIS295 3.2 16.4 1.0
CE2 A:TYR383 3.6 19.3 1.0
C23 A:RZB708 3.9 27.1 1.0
CG A:GLU318 4.0 19.9 1.0
OH A:TYR383 4.1 27.0 1.0
CG A:HIS295 4.1 16.6 1.0
CG2 A:THR321 4.2 14.2 1.0
ND1 A:HIS299 4.2 16.4 1.0
CG A:HIS299 4.3 14.6 1.0
CZ A:TYR383 4.3 26.8 1.0
ND1 A:HIS295 4.3 17.4 1.0
N22 A:RZB708 4.3 19.3 1.0
O A:HOH817 4.4 28.1 1.0
CD2 A:TYR383 4.5 18.4 1.0
C21 A:RZB708 4.7 21.7 1.0
CB A:THR321 4.7 16.6 1.0
OE1 A:GLU271 4.7 19.7 1.0
CB A:GLU318 4.8 15.4 1.0
OE1 A:GLU296 4.8 22.8 1.0
O A:HOH1248 4.8 55.0 1.0
OE2 A:GLU271 5.0 17.4 1.0
CA A:GLU318 5.0 14.4 1.0

Reference:

C.Markert, G.Thoma, H.Srinivas, B.Bollbuck, R.M.Luond, W.Miltz, R.Wal̈Chli, R.Wolf, J.Hinrichs, C.Bergsdorf, K.Azzaoui, C.A.Penno, K.Klein, N.Wack, P.Jag̈Er, F.Hasler, C.Beerli, P.Loetscher, J.Dawson, G.Wieczorek, S.Numao, A.Littlewood-Evans, T.A.Rohn. Discovery of LYS006, A Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
Page generated: Wed Mar 3 16:18:47 2021

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