Zinc in PDB 7a6u: Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6

The binding sites of Zinc atom in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 (pdb code 7a6u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6, PDB code: 7a6u:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2000 b:0.8 occ:1.00 ND1 A:HIS249 2.0 0.8 1.0 SG A:CYS255 2.3 0.5 1.0 SG A:CYS253 2.3 0.4 1.0 CB A:CYS253 2.5 0.4 1.0 CE1 A:HIS249 2.9 0.8 1.0 CG A:HIS249 3.1 0.8 1.0 CB A:CYS258 3.2 0.5 1.0 CB A:HIS249 3.5 0.8 1.0 CB A:CYS255 3.7 0.5 1.0 CA A:CYS253 3.9 0.4 1.0 SG A:CYS258 4.0 0.5 1.0 NE2 A:HIS249 4.1 0.8 1.0 N A:CYS255 4.1 0.5 1.0 CD2 A:HIS249 4.2 0.8 1.0 C A:CYS253 4.2 0.4 1.0 CA A:CYS255 4.4 0.5 1.0 CA A:CYS258 4.4 0.5 1.0 N A:CYS258 4.5 0.5 1.0 O A:CYS253 4.5 0.4 1.0 O A:CYS255 4.6 0.5 1.0 N A:LYS254 4.7 0.0 1.0 N A:CYS253 4.8 0.4 1.0 C A:CYS255 4.9 0.5 1.0 CA A:HIS249 4.9 0.8 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2000 b:0.3 occ:1.00 ND1 B:HIS249 2.0 0.1 1.0 SG B:CYS255 2.3 0.6 1.0 SG B:CYS253 2.3 0.6 1.0 CB B:CYS253 2.5 0.6 1.0 CE1 B:HIS249 2.9 0.1 1.0 CG B:HIS249 3.1 0.1 1.0 CB B:CYS258 3.2 0.6 1.0 CB B:HIS249 3.5 0.1 1.0 CB B:CYS255 3.7 0.6 1.0 CA B:CYS253 3.9 0.6 1.0 SG B:CYS258 4.0 0.6 1.0 NE2 B:HIS249 4.1 0.1 1.0 N B:CYS255 4.1 0.6 1.0 CD2 B:HIS249 4.2 0.1 1.0 C B:CYS253 4.2 0.6 1.0 CA B:CYS255 4.4 0.6 1.0 CA B:CYS258 4.4 0.6 1.0 N B:CYS258 4.5 0.6 1.0 O B:CYS253 4.5 0.6 1.0 O B:CYS255 4.6 0.6 1.0 N B:LYS254 4.7 0.5 1.0 N B:CYS253 4.8 0.6 1.0 C B:CYS255 4.9 0.6 1.0 CA B:HIS249 4.9 0.1 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2000 b:0.7 occ:1.00 ND1 C:HIS249 2.0 0.1 1.0 SG C:CYS255 2.3 0.7 1.0 SG C:CYS253 2.3 0.7 1.0 CB C:CYS253 2.5 0.7 1.0 CE1 C:HIS249 2.9 0.1 1.0 CG C:HIS249 3.1 0.1 1.0 CB C:CYS258 3.2 0.4 1.0 CB C:HIS249 3.5 0.1 1.0 CB C:CYS255 3.7 0.7 1.0 CA C:CYS253 3.9 0.7 1.0 SG C:CYS258 4.0 0.4 1.0 NE2 C:HIS249 4.1 0.1 1.0 N C:CYS255 4.1 0.7 1.0 CD2 C:HIS249 4.2 0.1 1.0 C C:CYS253 4.2 0.7 1.0 CA C:CYS255 4.4 0.7 1.0 CA C:CYS258 4.4 0.4 1.0 N C:CYS258 4.5 0.4 1.0 O C:CYS253 4.5 0.7 1.0 O C:CYS255 4.6 0.7 1.0 N C:LYS254 4.7 0.3 1.0 N C:CYS253 4.8 0.7 1.0 C C:CYS255 4.9 0.7 1.0 CA C:HIS249 4.9 0.1 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2000 b:0.1 occ:1.00 ND1 D:HIS249 2.0 0.8 1.0 SG D:CYS255 2.3 0.2 1.0 SG D:CYS253 2.3 0.5 1.0 CB D:CYS253 2.5 0.5 1.0 CE1 D:HIS249 2.9 0.8 1.0 CG D:HIS249 3.1 0.8 1.0 CB D:CYS258 3.2 1.0 1.0 CB D:HIS249 3.5 0.8 1.0 CB D:CYS255 3.7 0.2 1.0 CA D:CYS253 3.9 0.5 1.0 SG D:CYS258 4.0 1.0 1.0 NE2 D:HIS249 4.1 0.8 1.0 N D:CYS255 4.1 0.2 1.0 CD2 D:HIS249 4.2 0.8 1.0 C D:CYS253 4.2 0.5 1.0 CA D:CYS255 4.4 0.2 1.0 CA D:CYS258 4.4 1.0 1.0 N D:CYS258 4.5 1.0 1.0 O D:CYS253 4.5 0.5 1.0 O D:CYS255 4.6 0.2 1.0 N D:LYS254 4.7 0.1 1.0 N D:CYS253 4.8 0.5 1.0 C D:CYS255 4.9 0.2 1.0 CA D:HIS249 4.9 0.8 1.0

M.Grieben, E.P.Carpenter. Cryo-Em Structure of the Cytoplasmic Domain of Human TRPC6 To Be Published.