Zinc in PDB 6wcz: Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex

The binding sites of Zinc atom in the Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex (pdb code 6wcz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex, PDB code: 6wcz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:0.2 occ:1.00 OE2 B:GLU439 2.1 0.5 1.0 NE2 B:HIS443 2.2 0.1 1.0 CE1 B:HIS443 2.4 0.1 1.0 SG B:CYS451 2.5 0.2 1.0 SG B:CYS448 2.6 0.4 1.0 CD B:GLU439 2.9 0.5 1.0 C B:SER450 3.1 0.1 1.0 O B:SER450 3.2 0.1 1.0 N B:SER450 3.3 0.1 1.0 N B:CYS451 3.3 0.2 1.0 CG B:GLU439 3.3 0.5 1.0 CB B:CYS451 3.5 0.2 1.0 CD2 B:HIS443 3.6 0.1 1.0 CA B:SER450 3.6 0.1 1.0 ND1 B:HIS443 3.7 0.1 1.0 OE1 B:GLU439 3.9 0.5 1.0 CA B:CYS451 3.9 0.2 1.0 CB B:SER450 4.1 0.1 1.0 CB B:CYS448 4.1 0.4 1.0 N B:HIS449 4.2 0.4 1.0 CG B:HIS443 4.3 0.1 1.0 C B:HIS449 4.4 0.4 1.0 CA B:CYS448 4.4 0.4 1.0 C B:CYS448 4.6 0.4 1.0 CB B:GLU439 4.9 0.5 1.0 CA B:HIS449 4.9 0.4 1.0

Zinc binding site 2 out of 2 in the Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryoem Structure of Full-Length Zikv NS5-HSTAT2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:0.2 occ:1.00 NE2 B:HIS714 2.1 0.4 1.0 ND2 B:ASN716 2.6 0.3 1.0 SG B:CYS849 2.9 0.7 1.0 CD2 B:HIS714 3.1 0.4 1.0 CE1 B:HIS714 3.2 0.4 1.0 SG B:CYS730 3.2 1.0 1.0 CG B:ASN716 3.8 0.3 1.0 CB B:CYS730 3.8 1.0 1.0 CD1 B:LEU841 4.1 0.5 1.0 CG B:HIS714 4.2 0.4 1.0 ND1 B:HIS714 4.2 0.4 1.0 CB B:CYS849 4.3 0.7 1.0 OD1 B:ASN716 4.3 0.3 1.0 O B:GLU845 4.6 0.5 1.0 NH2 B:ARG771 4.7 0.8 1.0 CB B:ASN716 4.9 0.3 1.0 CD2 B:LEU841 5.0 0.5 1.0

W.Boxiao, T.Stephanie, Z.Kang, T.S.Maria, F.Jian, L.Jiuwei, G.Linfeng, R.Wendan, C.Yanxiang, C.V.Ethan, H.Heajin, J.E.Matthew, E.O.Sean, G.S.Adolfo, Z.Hong, H.Rong, S.Jikui. Structural Basis For STAT2 Suppression By Flavivirus NS5 Nat.Struct.Mol.Biol. 2020.
ISSN: ESSN 1545-9985
PubMed: 32778820
DOI: 10.1038/S41594-020-0472-Y