Zinc in PDB 6mm1: Structure of the Cysteine-Rich Region From Human EHMT2

All present enzymatic activity of Structure of the Cysteine-Rich Region From Human EHMT2:
2.1.1.43;

The structure of Structure of the Cysteine-Rich Region From Human EHMT2, PDB code: 6mm1 was solved by K.M.Kerchner, T.C.Mou, S.R.Sprang, K.Briknarova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.51 / 1.90
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	47.996, 54.358, 59.317, 91.68, 100.92, 96.89
R / Rfree (%)	17.4 / 22.3

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Zinc atom in the Structure of the Cysteine-Rich Region From Human EHMT2 (pdb code 6mm1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 16 binding sites of Zinc where determined in the Structure of the Cysteine-Rich Region From Human EHMT2, PDB code: 6mm1:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:14.8 occ:1.00 ND1 A:HIS75 1.9 17.2 1.0 ND1 A:HIS119 2.1 14.8 1.0 SG A:CYS10 2.3 17.7 1.0 SG A:CYS12 2.3 14.4 1.0 CE1 A:HIS75 2.7 16.1 1.0 CG A:HIS75 3.0 17.4 1.0 CE1 A:HIS119 3.1 14.8 1.0 CB A:CYS10 3.1 17.1 1.0 CB A:CYS12 3.2 14.5 1.0 CG A:HIS119 3.2 22.9 1.0 CB A:HIS119 3.5 15.0 1.0 CB A:HIS75 3.6 15.3 1.0 NE2 A:HIS75 3.9 20.0 1.0 CA A:HIS75 4.0 15.0 1.0 CD2 A:HIS75 4.1 15.1 1.0 NE2 A:HIS119 4.2 19.7 1.0 CA A:HIS119 4.2 14.9 1.0 CD2 A:HIS119 4.3 15.0 1.0 N A:CYS12 4.3 17.1 1.0 CA A:CYS12 4.4 16.6 1.0 O A:HOH640 4.5 15.2 1.0 CA A:CYS10 4.5 17.1 1.0 O A:HOH673 4.5 32.8 1.0 CG A:PRO79 4.9 17.1 1.0 C A:CYS10 4.9 21.0 1.0 N A:HIS75 4.9 15.1 1.0

Zinc binding site 2 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:20.4 occ:1.00 SG A:CYS81 2.3 19.9 1.0 SG A:CYS107 2.3 21.1 1.0 SG A:CYS78 2.4 15.3 1.0 ND1 A:HIS104 2.6 17.7 1.0 CB A:CYS78 3.1 18.1 1.0 CB A:CYS107 3.2 22.0 1.0 CG A:HIS104 3.3 14.9 1.0 CB A:CYS81 3.4 24.1 1.0 CE1 A:HIS104 3.5 16.5 1.0 CB A:HIS104 3.5 18.7 1.0 N A:CYS81 3.6 23.1 1.0 CA A:CYS81 4.1 24.9 1.0 N A:HIS104 4.1 17.3 1.0 O A:HOH726 4.2 28.3 1.0 O A:HOH739 4.2 39.1 1.0 CD2 A:HIS104 4.3 15.1 1.0 NE2 A:HIS104 4.4 21.2 1.0 C A:GLY80 4.4 20.2 1.0 CA A:HIS104 4.4 18.4 1.0 CA A:GLY80 4.5 14.5 1.0 CA A:CYS78 4.5 14.5 1.0 N A:GLY80 4.5 14.3 1.0 CA A:CYS107 4.7 20.8 1.0 C A:CYS78 4.9 14.6 1.0 O A:CYS78 4.9 15.2 1.0 C A:CYS81 5.0 21.2 1.0

Zinc binding site 3 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:22.1 occ:1.00 ND1 A:HIS68 2.0 20.9 1.0 SG A:CYS65 2.3 23.6 1.0 SG A:CYS43 2.3 26.7 1.0 SG A:CYS30 2.3 20.1 1.0 CE1 A:HIS68 3.0 18.9 1.0 CG A:HIS68 3.1 20.0 1.0 CB A:CYS30 3.1 21.3 1.0 CB A:CYS43 3.3 21.6 1.0 CB A:CYS65 3.4 23.1 1.0 CB A:HIS68 3.5 17.3 1.0 N A:CYS65 4.0 17.6 1.0 NE2 A:HIS68 4.1 20.4 1.0 CD2 A:HIS68 4.2 21.6 1.0 CB A:ALA32 4.2 18.2 1.0 CA A:CYS65 4.2 21.8 1.0 N A:HIS68 4.4 18.1 1.0 CA A:HIS68 4.6 15.9 1.0 CA A:CYS30 4.6 19.8 1.0 CB A:ALA45 4.7 23.3 1.0 CA A:CYS43 4.7 23.7 1.0 C A:CYS65 4.8 20.6 1.0 O A:CYS65 4.9 17.6 1.0 N A:ALA45 5.0 25.8 1.0

Zinc binding site 4 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn504 b:19.6 occ:1.00 ND1 A:HIS101 2.1 15.7 1.0 SG A:CYS117 2.3 16.6 1.0 SG A:CYS120 2.3 23.1 1.0 SG A:CYS93 2.4 23.0 1.0 CE1 A:HIS101 3.1 18.6 1.0 CB A:CYS117 3.2 18.5 1.0 CG A:HIS101 3.2 16.1 1.0 CB A:CYS93 3.3 22.2 1.0 CB A:CYS120 3.4 21.4 1.0 CB A:HIS101 3.5 16.5 1.0 N A:CYS120 3.8 18.6 1.0 CA A:CYS120 4.1 19.4 1.0 NE2 A:HIS101 4.2 16.7 1.0 CD2 A:HIS101 4.3 15.6 1.0 CB A:HIS119 4.4 15.0 1.0 CA A:CYS117 4.6 19.0 1.0 CB A:GLU122 4.7 40.5 1.0 CA A:CYS93 4.7 22.9 1.0 C A:CYS120 4.8 24.5 1.0 N A:GLY121 4.8 26.8 1.0 C A:HIS119 4.8 18.3 1.0 CD A:PRO95 4.9 20.9 1.0 N A:GLU122 4.9 25.7 1.0 C A:CYS93 4.9 22.3 1.0 O A:HOH674 4.9 32.6 1.0 CG A:PRO95 4.9 24.5 1.0 CA A:HIS101 5.0 15.6 1.0 N A:HIS119 5.0 15.0 1.0 CA A:HIS119 5.0 14.9 1.0

Zinc binding site 5 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:16.6 occ:1.00 ND1 B:HIS119 2.1 17.5 1.0 ND1 B:HIS75 2.2 16.9 1.0 SG B:CYS12 2.3 16.8 1.0 SG B:CYS10 2.4 16.4 1.0 CE1 B:HIS119 3.0 17.2 1.0 CB B:CYS10 3.1 16.1 1.0 CE1 B:HIS75 3.1 17.9 1.0 CB B:CYS12 3.1 17.2 1.0 CG B:HIS119 3.2 19.2 1.0 CG B:HIS75 3.2 18.0 1.0 CB B:HIS119 3.5 16.7 1.0 CB B:HIS75 3.6 17.0 1.0 CA B:HIS75 4.0 17.2 1.0 NE2 B:HIS119 4.2 16.5 1.0 NE2 B:HIS75 4.2 20.0 1.0 N B:CYS12 4.3 17.0 1.0 CD2 B:HIS119 4.3 18.9 1.0 CA B:CYS12 4.3 17.3 1.0 CD2 B:HIS75 4.3 18.3 1.0 CA B:HIS119 4.4 15.7 1.0 CA B:CYS10 4.5 16.0 1.0 O B:HOH664 4.6 17.2 1.0 CG B:PRO79 4.9 16.4 1.0 N B:HIS75 5.0 17.5 1.0 C B:HIS75 5.0 17.1 1.0 C B:CYS10 5.0 16.3 1.0

Zinc binding site 6 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn502 b:22.9 occ:1.00 ND1 B:HIS104 2.2 18.4 1.0 SG B:CYS81 2.3 18.8 1.0 SG B:CYS78 2.3 16.0 1.0 SG B:CYS107 2.3 21.1 1.0 CE1 B:HIS104 3.1 20.6 1.0 CB B:CYS78 3.1 17.4 1.0 CB B:CYS81 3.2 19.9 1.0 CG B:HIS104 3.3 18.4 1.0 CB B:CYS107 3.3 17.9 1.0 N B:CYS81 3.5 26.2 1.0 CB B:HIS104 3.6 18.7 1.0 CA B:CYS81 4.0 22.5 1.0 N B:HIS104 4.1 23.0 1.0 O B:HOH715 4.2 58.7 1.0 NE2 B:HIS104 4.3 18.6 1.0 CD2 B:HIS104 4.4 18.5 1.0 C B:GLY80 4.4 22.9 1.0 CA B:HIS104 4.5 19.5 1.0 CA B:GLY80 4.5 20.3 1.0 CA B:CYS78 4.6 16.2 1.0 N B:GLY80 4.6 21.2 1.0 CA B:CYS107 4.7 19.3 1.0 C B:CYS81 4.8 22.1 1.0 C B:CYS78 4.9 18.2 1.0 N B:GLY82 4.9 18.2 1.0 O B:CYS78 4.9 16.2 1.0 O B:HOH704 5.0 34.9 1.0

Zinc binding site 7 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn503 b:23.9 occ:1.00 ND1 B:HIS68 2.0 27.6 1.0 SG B:CYS65 2.3 24.7 1.0 SG B:CYS30 2.3 20.5 1.0 SG B:CYS43 2.4 26.2 1.0 CE1 B:HIS68 2.9 29.3 1.0 CB B:CYS30 3.1 20.6 1.0 CG B:HIS68 3.1 26.1 1.0 CB B:CYS43 3.3 27.2 1.0 CB B:CYS65 3.4 23.7 1.0 CB B:HIS68 3.6 24.7 1.0 N B:CYS65 4.0 21.9 1.0 NE2 B:HIS68 4.0 28.8 1.0 CD2 B:HIS68 4.2 27.6 1.0 CA B:CYS65 4.3 24.8 1.0 CB B:ALA32 4.3 20.7 1.0 N B:HIS68 4.4 24.6 1.0 CA B:CYS30 4.5 23.8 1.0 CA B:HIS68 4.7 24.4 1.0 CA B:CYS43 4.7 26.9 1.0 CB B:ALA45 4.8 25.4 1.0 C B:CYS65 4.9 24.6 1.0 O B:CYS65 4.9 20.5 1.0

Zinc binding site 8 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn504 b:15.8 occ:1.00 ND1 B:HIS101 2.2 21.1 1.0 SG B:CYS120 2.3 17.0 1.0 SG B:CYS117 2.3 15.5 1.0 SG B:CYS93 2.4 18.1 1.0 CG B:HIS101 3.1 19.1 1.0 CB B:CYS117 3.2 25.4 1.0 CE1 B:HIS101 3.2 16.6 1.0 CB B:CYS93 3.3 17.3 1.0 CB B:HIS101 3.3 16.1 1.0 CB B:CYS120 3.4 15.8 1.0 N B:CYS120 3.8 15.6 1.0 CA B:CYS120 4.1 15.6 1.0 CD2 B:HIS101 4.2 16.1 1.0 NE2 B:HIS101 4.3 18.3 1.0 CB B:HIS119 4.4 16.7 1.0 CG B:PRO95 4.4 22.6 1.0 CA B:CYS93 4.6 18.6 1.0 CA B:CYS117 4.6 19.7 1.0 CB B:GLU122 4.6 29.1 1.0 CD B:PRO95 4.7 21.6 1.0 O B:CYS93 4.7 20.0 1.0 C B:HIS119 4.7 15.7 1.0 C B:CYS93 4.8 20.5 1.0 O B:HOH682 4.8 35.9 1.0 C B:CYS120 4.8 15.3 1.0 CA B:HIS101 4.8 16.6 1.0 N B:GLU122 4.9 23.2 1.0 CB B:PRO95 4.9 26.4 1.0 N B:GLY121 4.9 15.2 1.0 CA B:HIS119 4.9 15.7 1.0 N B:HIS119 5.0 16.2 1.0

Zinc binding site 9 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn501 b:17.7 occ:1.00 ND1 C:HIS75 2.0 17.9 1.0 ND1 C:HIS119 2.2 17.3 1.0 SG C:CYS12 2.3 19.9 1.0 SG C:CYS10 2.3 17.7 1.0 CE1 C:HIS75 2.9 20.6 1.0 CB C:CYS10 3.1 17.6 1.0 CB C:CYS12 3.1 22.6 1.0 CG C:HIS75 3.1 21.2 1.0 CG C:HIS119 3.2 19.3 1.0 CE1 C:HIS119 3.2 17.1 1.0 CB C:HIS119 3.4 17.9 1.0 CB C:HIS75 3.6 18.3 1.0 CA C:HIS75 4.0 16.8 1.0 NE2 C:HIS75 4.1 21.6 1.0 CA C:HIS119 4.1 18.1 1.0 CD2 C:HIS75 4.2 20.6 1.0 NE2 C:HIS119 4.3 17.2 1.0 N C:CYS12 4.3 22.7 1.0 CD2 C:HIS119 4.3 17.6 1.0 CA C:CYS12 4.3 23.4 1.0 O C:HOH634 4.5 22.1 1.0 CA C:CYS10 4.5 17.9 1.0 CG C:PRO79 4.7 17.9 1.0 O C:HOH713 4.9 44.0 1.0 N C:HIS75 4.9 16.7 1.0 C C:HIS119 4.9 18.9 1.0 C C:HIS75 5.0 20.7 1.0 C C:CYS10 5.0 17.8 1.0

Zinc binding site 10 out of 16 in the Structure of the Cysteine-Rich Region From Human EHMT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Structure of the Cysteine-Rich Region From Human EHMT2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn502 b:23.8 occ:1.00 ND1 C:HIS104 2.1 28.6 1.0 SG C:CYS81 2.3 21.6 1.0 SG C:CYS78 2.4 20.5 1.0 SG C:CYS107 2.4 24.2 1.0 CE1 C:HIS104 3.0 28.7 1.0 CG C:HIS104 3.1 28.9 1.0 CB C:CYS78 3.2 19.0 1.0 CB C:CYS107 3.3 23.7 1.0 CB C:CYS81 3.3 20.9 1.0 CB C:HIS104 3.5 27.2 1.0 N C:CYS81 3.5 21.9 1.0 CA C:CYS81 4.0 23.1 1.0 N C:HIS104 4.1 23.8 1.0 NE2 C:HIS104 4.1 29.6 1.0 O C:HOH719 4.1 60.4 1.0 CD2 C:HIS104 4.2 30.3 1.0 CA C:HIS104 4.4 26.6 1.0 C C:GLY80 4.4 24.9 1.0 CA C:CYS78 4.6 19.6 1.0 CA C:GLY80 4.6 18.1 1.0 N C:GLY80 4.6 22.2 1.0 CA C:CYS107 4.7 20.9 1.0 O C:CYS78 4.8 17.4 1.0 C C:CYS78 4.8 18.5 1.0 O C:HOH687 4.9 52.7 1.0 C C:CYS81 4.9 20.6 1.0

K.M.Kerchner, T.C.Mou, S.R.Sprang, K.Briknarova. Structure of the Cysteine-Rich Region From Human EHMT2 To Be Published.