Zinc in PDB 5ofa: Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R

The structure of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R, PDB code: 5ofa was solved by C.H.Douse, Y.Liu, Y.Modis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	80.75 / 2.57
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	69.610, 125.730, 81.530, 90.00, 97.91, 90.00
R / Rfree (%)	21.1 / 23.9

The structure of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R (pdb code 5ofa). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R, PDB code: 5ofa:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:81.6 occ:1.00 SG B:CYS525 1.9 69.8 1.0 SG B:CYS499 2.0 75.2 1.0 SG B:CYS502 2.5 71.0 1.0 CB B:CYS499 2.7 75.5 1.0 SG B:CYS536 2.7 77.3 1.0 CB B:CYS525 3.1 70.3 1.0 CB B:CYS536 3.5 67.3 1.0 N B:CYS525 3.6 66.3 1.0 CA B:CYS536 3.6 71.4 1.0 CB B:CYS502 3.7 64.5 1.0 CA B:CYS525 3.9 71.2 1.0 N B:CYS502 3.9 70.8 1.0 CA B:CYS499 4.2 74.2 1.0 N B:CYS536 4.3 78.7 1.0 CA B:CYS502 4.4 69.4 1.0 CB B:LEU501 4.6 74.5 1.0 C B:VAL524 4.7 69.5 1.0 C B:CYS499 4.8 68.5 1.0 C B:CYS536 4.8 73.3 1.0 O B:CYS536 4.9 72.8 1.0 CA B:VAL524 5.0 71.6 1.0 C B:LEU501 5.0 69.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:0.1 occ:1.00 SG A:CYS536 2.0 0.3 1.0 SG A:CYS525 2.1 0.0 1.0 SG A:CYS502 2.6 0.0 1.0 SG A:CYS499 2.6 0.6 1.0 CB A:CYS536 2.9 0.8 1.0 CB A:CYS525 3.0 0.5 1.0 CA A:CYS536 3.1 0.9 1.0 CB A:CYS499 3.3 0.4 1.0 CB A:CYS502 3.5 0.8 1.0 N A:CYS525 3.7 0.8 1.0 N A:CYS536 3.8 0.3 1.0 CA A:CYS525 3.9 0.1 1.0 N A:CYS502 4.1 0.5 1.0 C A:CYS536 4.4 0.0 1.0 CA A:CYS502 4.4 0.9 1.0 O A:CYS536 4.5 0.5 1.0 CG2 A:VAL524 4.6 0.2 1.0 C A:ARG535 4.7 0.8 1.0 CA A:CYS499 4.8 0.3 1.0 NH2 A:ARG506 4.9 0.1 1.0 CB A:LEU501 4.9 0.7 1.0 C A:VAL524 4.9 0.3 1.0 O A:ARG535 4.9 0.4 1.0

C.H.Douse, S.Bloor, Y.Liu, M.Shamin, I.A.Tchasovnikarova, R.T.Timms, P.J.Lehner, Y.Modis. Neuropathic MORC2 Mutations Perturb Ghkl Atpase Dimerization Dynamics and Epigenetic Silencing By Multiple Structural Mechanisms. Nat Commun V. 9 651 2018.
ISSN: ESSN 2041-1723
PubMed: 29440755
DOI: 10.1038/S41467-018-03045-X