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Zinc in PDB 3blo: Tgt Mutant in Complex with Queuine

Enzymatic activity of Tgt Mutant in Complex with Queuine

All present enzymatic activity of Tgt Mutant in Complex with Queuine:
2.4.2.29;

Protein crystallography data

The structure of Tgt Mutant in Complex with Queuine, PDB code: 3blo was solved by N.Tidten, A.Heine, K.Reuter, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 1.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.380, 64.780, 70.320, 90.00, 95.91, 90.00
R / Rfree (%) 18 / 21.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Tgt Mutant in Complex with Queuine (pdb code 3blo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Tgt Mutant in Complex with Queuine, PDB code: 3blo:

Zinc binding site 1 out of 1 in 3blo

Go back to Zinc Binding Sites List in 3blo
Zinc binding site 1 out of 1 in the Tgt Mutant in Complex with Queuine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Tgt Mutant in Complex with Queuine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn500

b:21.0
occ:1.00
ND1 A:HIS349 2.2 19.2 1.0
SG A:CYS323 2.2 21.1 1.0
SG A:CYS318 2.3 22.9 1.0
SG A:CYS320 2.3 22.0 1.0
CE1 A:HIS349 2.9 19.1 1.0
CB A:CYS318 3.2 24.6 1.0
CB A:CYS323 3.3 17.5 1.0
CB A:CYS320 3.3 25.2 1.0
CG A:HIS349 3.3 18.8 1.0
CB A:HIS349 3.8 18.2 1.0
N A:CYS323 3.9 19.0 1.0
CA A:HIS349 4.2 17.5 1.0
NE2 A:HIS349 4.2 21.4 1.0
N A:CYS320 4.2 19.6 1.0
CA A:CYS323 4.2 20.8 1.0
CA A:CYS320 4.2 21.1 1.0
CD2 A:HIS349 4.3 17.8 1.0
CA A:CYS318 4.6 20.8 1.0
O A:HIS349 4.6 17.8 1.0
C A:CYS320 4.7 18.0 1.0
O A:CYS320 4.7 21.6 1.0
C A:CYS318 4.7 22.7 1.0
C A:HIS349 4.8 16.0 1.0
CB A:VAL322 4.8 22.5 1.0
C A:VAL322 4.9 23.0 1.0
O A:CYS318 4.9 25.8 1.0

Reference:

I.Biela, N.Tidten-Luksch, F.Immekus, S.Glinca, T.X.Nguyen, H.D.Gerber, A.Heine, G.Klebe, K.Reuter. Investigation of Specificity Determinants in Bacterial Trna-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, As Inhibitor Plos One V. 8 64240 2013.
ISSN: ESSN 1932-6203
PubMed: 23704982
DOI: 10.1371/JOURNAL.PONE.0064240
Page generated: Thu Oct 24 11:35:34 2024

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