Zinc in PDB 2z4g: Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8

All present enzymatic activity of Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8:
3.1.3.15;

The structure of Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8, PDB code: 2z4g was solved by R.Omi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.99 / 1.80
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	84.961, 96.786, 74.716, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 26.8

The structure of Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8 also contains other interesting chemical elements:

Iron

(Fe)

4 atoms

The binding sites of Zinc atom in the Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8 (pdb code 2z4g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8, PDB code: 2z4g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:28.9 occ:1.00 NE2 A:HIS38 2.1 20.3 1.0 NE2 A:HIS13 2.1 22.9 1.0 NE2 A:HIS226 2.2 22.9 1.0 CE1 A:HIS226 2.9 23.1 1.0 CD2 A:HIS38 2.9 20.9 1.0 CD2 A:HIS13 3.0 20.7 1.0 O A:HOH631 3.1 21.4 1.0 CE1 A:HIS38 3.1 21.5 1.0 CE1 A:HIS13 3.2 21.1 1.0 CD2 A:HIS226 3.3 21.9 1.0 O A:HOH682 4.1 40.3 1.0 ND1 A:HIS226 4.1 22.9 1.0 CG A:HIS38 4.1 20.8 1.0 ND1 A:HIS38 4.2 21.2 1.0 CE1 A:HIS7 4.2 21.3 1.0 NE2 A:HIS7 4.2 20.7 1.0 CG A:HIS13 4.2 23.5 1.0 ND1 A:HIS13 4.3 22.3 1.0 ND1 A:HIS7 4.3 19.4 1.0 CG A:HIS226 4.3 22.4 1.0 CD2 A:HIS7 4.4 18.1 1.0 CG A:HIS7 4.4 20.4 1.0 SG A:CYS11 4.5 20.2 1.0 FE A:FE503 4.6 24.9 1.0

Zinc binding site 2 out of 2 in the Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1501 b:27.2 occ:1.00 NE2 B:HIS38 2.1 19.5 1.0 NE2 B:HIS226 2.1 20.8 1.0 NE2 B:HIS13 2.2 20.5 1.0 O B:HOH1504 2.9 15.0 1.0 CD2 B:HIS13 3.0 21.1 1.0 CE1 B:HIS38 3.1 17.6 1.0 CD2 B:HIS226 3.1 17.9 1.0 CD2 B:HIS38 3.1 16.7 1.0 CE1 B:HIS226 3.2 18.8 1.0 CE1 B:HIS13 3.3 19.4 1.0 ND1 B:HIS38 4.2 14.9 1.0 CE1 B:HIS7 4.2 19.6 1.0 CG B:HIS38 4.2 17.7 1.0 CG B:HIS13 4.2 22.4 1.0 ND1 B:HIS226 4.2 19.8 1.0 CG B:HIS226 4.2 20.3 1.0 NE2 B:HIS7 4.3 19.3 1.0 ND1 B:HIS7 4.3 19.5 1.0 ND1 B:HIS13 4.3 20.2 1.0 CD2 B:HIS7 4.5 21.1 1.0 CG B:HIS7 4.5 19.4 1.0 SG B:CYS11 4.6 21.3 1.0 O B:HOH1537 4.6 27.7 1.0 FE B:FE1503 4.7 25.2 1.0

R.Omi, M.Goto, I.Miyahara, M.Manzoku, A.Ebihara, K.Hirotsu. Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase From Thermus Thermophilus HB8. Biochemistry V. 46 12618 2007.
ISSN: ISSN 0006-2960
PubMed: 17929834
DOI: 10.1021/BI701204R