Zinc in PDB 2mls: Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face

All present enzymatic activity of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face:
3.4.24.65;

The structure of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face also contains other interesting chemical elements:

Calcium

(Ca)

42 atoms

The binding sites of Zinc atom in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face (pdb code 2mls). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face, PDB code: 2mls:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:0.0 occ:1.00 ND1 A:HIS218 2.3 0.0 1.0 CE1 A:HIS218 3.0 0.0 1.0 HE1 A:HIS218 3.0 0.0 1.0 CG A:HIS218 3.5 0.0 1.0 HE1 A:HIS228 3.8 0.0 1.0 HA A:MET236 3.9 0.0 1.0 HB3 A:HIS218 3.9 0.0 1.0 O A:PHE237 3.9 0.0 1.0 HB2 A:HIS218 4.1 0.0 1.0 NE2 A:HIS218 4.1 0.0 1.0 CB A:HIS218 4.2 0.0 1.0 O A:VAL235 4.3 0.0 1.0 HA A:PRO238 4.3 0.0 1.0 CE1 A:HIS228 4.3 0.0 1.0 CD2 A:HIS218 4.4 0.0 1.0 ND1 A:HIS228 4.5 0.0 1.0 O A:PRO238 4.6 0.0 1.0 HE2 A:HIS222 4.7 0.0 1.0 CA A:MET236 4.9 0.0 1.0 HE2 A:HIS218 4.9 0.0 1.0 O A:MET236 4.9 0.0 1.0

Zinc binding site 2 out of 2 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Beta- Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:0.0 occ:1.00 OD2 A:ASP170 1.9 0.0 1.0 OD1 A:ASP170 2.0 0.0 1.0 ND1 A:HIS172 2.1 0.0 1.0 NE2 A:HIS168 2.2 0.0 1.0 ND1 A:HIS183 2.2 0.0 1.0 CG A:ASP170 2.4 0.0 1.0 CE1 A:HIS172 2.9 0.0 1.0 CE1 A:HIS168 3.0 0.0 1.0 HE1 A:HIS168 3.0 0.0 1.0 CE1 A:HIS183 3.1 0.0 1.0 CG A:HIS172 3.1 0.0 1.0 HE1 A:HIS172 3.2 0.0 1.0 HE1 A:HIS183 3.3 0.0 1.0 CG A:HIS183 3.4 0.0 1.0 CD2 A:HIS168 3.5 0.0 1.0 HB3 A:HIS172 3.5 0.0 1.0 HB3 A:HIS183 3.6 0.0 1.0 HB2 A:HIS183 3.8 0.0 1.0 CB A:HIS172 3.8 0.0 1.0 O A:GLY169 3.9 0.0 1.0 CB A:HIS183 3.9 0.0 1.0 CB A:ASP170 3.9 0.0 1.0 HD2 A:HIS168 3.9 0.0 1.0 NE2 A:HIS172 4.0 0.0 1.0 HZ A:PHE185 4.0 0.0 1.0 CD2 A:HIS172 4.1 0.0 1.0 ND1 A:HIS196 4.1 0.0 1.0 HB2 A:ASP170 4.2 0.0 1.0 ND1 A:HIS168 4.2 0.0 1.0 NE2 A:HIS183 4.3 0.0 1.0 H A:ALA173 4.4 0.0 1.0 HB3 A:ASP170 4.4 0.0 1.0 CD2 A:HIS183 4.5 0.0 1.0 CG A:HIS168 4.5 0.0 1.0 HB2 A:HIS172 4.5 0.0 1.0 CE2 A:PHE174 4.6 0.0 1.0 CZ A:PHE174 4.6 0.0 1.0 HB2 A:HIS196 4.6 0.0 1.0 H A:HIS172 4.6 0.0 1.0 HB3 A:HIS196 4.8 0.0 1.0 HE2 A:PHE174 4.8 0.0 1.0 HZ A:PHE174 4.8 0.0 1.0 CZ A:PHE185 4.8 0.0 1.0 C A:GLY169 4.8 0.0 1.0 HE2 A:HIS172 4.8 0.0 1.0 HE1 A:HIS196 4.8 0.0 1.0 CA A:ASP170 4.9 0.0 1.0 CE1 A:HIS196 4.9 0.0 1.0 CA A:HIS172 4.9 0.0 1.0 HE1 A:PHE185 4.9 0.0 1.0 N A:ALA173 5.0 0.0 1.0

R.K.Koppisetti, Y.G.Fulcher, A.Jurkevich, S.H.Prior, J.Xu, M.Lenoir, M.Overduin, S.R.Van Doren. Ambidextrous Binding of Cell and Membrane Bilayers By Soluble Matrix Metalloproteinase-12. Nat Commun V. 5 5552 2014.
ISSN: ESSN 2041-1723
PubMed: 25412686
DOI: 10.1038/NCOMMS6552