Zinc in PDB 1z3j: Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh)

All present enzymatic activity of Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh):
3.4.24.65;

The structure of Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh) also contains other interesting chemical elements:

Calcium

(Ca)

3 atoms

The binding sites of Zinc atom in the Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh) (pdb code 1z3j). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh), PDB code: 1z3j:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn264 b:0.0 occ:1.00 NE2 A:HIS218 2.1 0.0 1.0 NE2 A:HIS222 2.1 0.0 1.0 O4 A:NGH269 2.1 0.0 1.0 NE2 A:HIS228 2.1 0.0 1.0 CE1 A:HIS218 2.9 0.0 1.0 HE1 A:HIS218 2.9 0.0 1.0 O5 A:NGH269 3.0 0.0 1.0 CD2 A:HIS228 3.0 0.0 1.0 N1 A:NGH269 3.0 0.0 1.0 CD2 A:HIS222 3.1 0.0 1.0 CE1 A:HIS222 3.1 0.0 1.0 CD2 A:HIS218 3.2 0.0 1.0 HD2 A:HIS228 3.2 0.0 1.0 CE1 A:HIS228 3.2 0.0 1.0 HD2 A:HIS222 3.2 0.0 1.0 HA A:PRO238 3.4 0.0 1.0 HE1 A:HIS222 3.4 0.0 1.0 C11 A:NGH269 3.4 0.0 1.0 HD2 A:HIS218 3.4 0.0 1.0 HE1 A:HIS228 3.5 0.0 1.0 HN1 A:NGH269 3.9 0.0 1.0 ND1 A:HIS218 4.1 0.0 1.0 CG A:HIS228 4.2 0.0 1.0 H92 A:NGH269 4.2 0.0 1.0 CG A:HIS218 4.2 0.0 1.0 CG A:HIS222 4.3 0.0 1.0 ND1 A:HIS228 4.3 0.0 1.0 ND1 A:HIS222 4.3 0.0 1.0 CA A:PRO238 4.4 0.0 1.0 HB3 A:PRO238 4.5 0.0 1.0 H5 A:NGH269 4.6 0.0 1.0 O A:PHE237 4.6 0.0 1.0 OE1 A:GLU219 4.9 0.0 1.0 C10 A:NGH269 4.9 0.0 1.0 HD1 A:HIS218 4.9 0.0 1.0 CB A:PRO238 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of MMP12 in the Presence of N-Isobutyl-N- 4-Methoxyphenylsulfonyl]Glycyl Hydroxamic Acid (Nngh) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn265 b:0.0 occ:1.00 OD1 A:ASP170 2.1 0.0 1.0 OD2 A:ASP170 2.2 0.0 1.0 NE2 A:HIS183 2.2 0.0 1.0 ND1 A:HIS196 2.3 0.0 1.0 NE2 A:HIS168 2.3 0.0 1.0 CG A:ASP170 2.5 0.0 1.0 CD2 A:HIS183 3.0 0.0 1.0 CE1 A:HIS168 3.0 0.0 1.0 HD2 A:HIS183 3.1 0.0 1.0 CE1 A:HIS196 3.2 0.0 1.0 CD2 A:HIS168 3.2 0.0 1.0 HE1 A:HIS168 3.3 0.0 1.0 CG A:HIS196 3.3 0.0 1.0 CE1 A:HIS183 3.3 0.0 1.0 HE1 A:HIS196 3.5 0.0 1.0 HD2 A:HIS168 3.6 0.0 1.0 HB2 A:HIS196 3.8 0.0 1.0 HE1 A:HIS183 3.8 0.0 1.0 HB3 A:HIS196 3.9 0.0 1.0 CB A:ASP170 3.9 0.0 1.0 CB A:HIS196 3.9 0.0 1.0 HB2 A:ASP170 4.0 0.0 1.0 ND1 A:HIS168 4.0 0.0 1.0 HA A:ALA173 4.1 0.0 1.0 CG A:HIS168 4.1 0.0 1.0 CG A:HIS183 4.2 0.0 1.0 NE2 A:HIS196 4.3 0.0 1.0 CD2 A:HIS196 4.3 0.0 1.0 HB3 A:ASP170 4.3 0.0 1.0 ND1 A:HIS183 4.3 0.0 1.0 HG12 A:ILE191 4.7 0.0 1.0 HD13 A:ILE191 4.9 0.0 1.0 HD1 A:HIS168 4.9 0.0 1.0

I.Bertini, V.Calderone, M.Cosenza, M.Fragai, Y.M.Lee, C.Luchinat, S.Mangani, B.Terni, P.Turano. Conformational Variability of Matrix Metalloproteinases: Beyond A Single 3D Structure. Proc.Natl.Acad.Sci.Usa V. 102 5334 2005.
ISSN: ISSN 0027-8424
PubMed: 15809432
DOI: 10.1073/PNAS.0407106102