Zinc in PDB 9ey6: Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)

Protein crystallography data

The structure of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1), PDB code: 9ey6 was solved by Y.M.Ng, M.Soler-Lopez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.97 / 2.23
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 103.754, 103.754, 140.988, 90, 90, 120
R / Rfree (%) 17 / 21.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) (pdb code 9ey6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1), PDB code: 9ey6:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 9ey6

Go back to Zinc Binding Sites List in 9ey6
Zinc binding site 1 out of 5 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn506

b:34.1
occ:1.00
NE2 A:HIS192 2.0 29.4 1.0
NE2 A:HIS215 2.1 40.7 1.0
NE2 A:HIS224 2.1 31.4 1.0
O A:HOH716 2.2 28.3 1.0
CE1 A:HIS192 3.0 35.6 1.0
CE1 A:HIS215 3.0 43.2 1.0
CD2 A:HIS192 3.0 32.9 1.0
CE1 A:HIS224 3.0 31.6 1.0
CD2 A:HIS215 3.1 38.5 1.0
CD2 A:HIS224 3.2 34.0 1.0
ZN A:ZN507 3.6 35.0 1.0
CE2 A:PHE400 4.0 36.4 1.0
CZ A:PHE400 4.0 38.6 1.0
O A:HOH763 4.0 54.0 1.0
ND1 A:HIS192 4.1 31.3 1.0
ND1 A:HIS215 4.1 39.5 1.0
NE2 A:HIS404 4.1 33.6 1.0
CG A:HIS192 4.2 28.2 1.0
ND1 A:HIS224 4.2 27.1 1.0
CG A:HIS215 4.2 39.2 1.0
CG A:HIS224 4.3 30.5 1.0
O A:HOH698 4.3 50.5 1.0
CE1 A:HIS404 4.6 34.1 1.0
CE1 A:PHE220 4.9 36.6 1.0
NE2 A:HIS377 4.9 36.2 1.0
CD2 A:HIS404 5.0 31.0 1.0

Zinc binding site 2 out of 5 in 9ey6

Go back to Zinc Binding Sites List in 9ey6
Zinc binding site 2 out of 5 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn507

b:35.0
occ:1.00
O A:HOH716 1.6 28.3 1.0
NE2 A:HIS404 2.0 33.6 1.0
NE2 A:HIS377 2.0 36.2 1.0
NE2 A:HIS381 2.1 39.4 1.0
CE1 A:HIS404 2.9 34.1 1.0
CD2 A:HIS377 3.0 37.7 1.0
CE1 A:HIS381 3.0 39.9 1.0
CD2 A:HIS404 3.0 31.0 1.0
CD2 A:HIS381 3.0 38.9 1.0
CE1 A:HIS377 3.1 36.8 1.0
ZN A:ZN506 3.6 34.1 1.0
O A:HOH763 3.9 54.0 1.0
CE2 A:PHE400 4.0 36.4 1.0
ND1 A:HIS404 4.0 31.2 1.0
ND1 A:HIS381 4.1 39.6 1.0
CG A:HIS404 4.1 33.9 1.0
CG A:HIS377 4.2 31.6 1.0
CG A:HIS381 4.2 36.7 1.0
ND1 A:HIS377 4.2 33.7 1.0
O A:HOH698 4.2 50.5 1.0
NE2 A:HIS224 4.3 31.4 1.0
CZ A:PHE400 4.5 38.6 1.0
CD2 A:HIS224 4.5 34.0 1.0
CD2 A:PHE400 4.6 37.4 1.0
CD2 A:LEU403 4.6 37.8 1.0
CE1 A:PHE220 4.6 36.6 1.0
CZ A:PHE220 4.9 33.2 1.0
NE2 A:HIS215 4.9 40.7 1.0

Zinc binding site 3 out of 5 in 9ey6

Go back to Zinc Binding Sites List in 9ey6
Zinc binding site 3 out of 5 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn508

b:54.5
occ:1.00
NE2 A:HIS75 1.9 51.3 1.0
NE2 A:HIS81 2.0 95.3 1.0
OE2 A:GLU88 2.1 64.1 1.0
OE1 A:GLU88 2.2 65.9 1.0
CD A:GLU88 2.5 58.1 1.0
CE1 A:HIS75 2.9 58.3 1.0
CD2 A:HIS75 3.0 53.4 1.0
CD2 A:HIS81 3.0 84.2 1.0
CE1 A:HIS81 3.0 94.5 1.0
CG A:GLU88 4.0 59.6 1.0
ND1 A:HIS75 4.0 46.4 1.0
ND1 A:HIS81 4.1 101.8 1.0
CG A:HIS81 4.1 97.6 1.0
CG A:HIS75 4.1 51.9 1.0
CD1 A:ILE432 4.6 43.9 1.0
CA A:GLY83 4.6 87.3 1.0
OE1 A:GLN78 4.9 82.4 1.0

Zinc binding site 4 out of 5 in 9ey6

Go back to Zinc Binding Sites List in 9ey6
Zinc binding site 4 out of 5 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn509

b:51.4
occ:1.00
OE2 A:GLU329 2.1 79.0 1.0
OE1 A:GLU329 2.2 66.5 1.0
CD A:GLU329 2.5 60.2 1.0
CG A:GLU329 4.0 59.8 1.0
NE A:ARG326 4.7 74.7 1.0

Zinc binding site 5 out of 5 in 9ey6

Go back to Zinc Binding Sites List in 9ey6
Zinc binding site 5 out of 5 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn510

b:54.0
occ:0.50
O A:HOH615 1.9 65.6 1.0
OE2 A:GLU241 2.0 71.7 1.0
OE1 A:GLU241 2.1 69.4 1.0
CD A:GLU241 2.3 70.7 1.0
CE1 A:HIS143 2.4 63.0 1.0
O A:HOH605 2.6 73.0 1.0
O A:HOH770 2.8 67.3 1.0
ND1 A:HIS143 3.2 67.6 1.0
O1 A:GOL505 3.3 86.4 1.0
NE2 A:HIS143 3.4 69.7 1.0
CG A:GLU241 3.8 62.5 1.0
CG A:HIS143 4.4 63.5 1.0
CD2 A:HIS143 4.4 68.2 1.0
O A:HOH664 4.5 58.6 1.0
C1 A:GOL505 4.7 74.1 1.0
O A:HOH694 4.8 44.3 1.0
CB A:GLU241 5.0 52.9 1.0

Reference:

C.Faure, Y.M.Ng, C.Belle, M.Soler-Lopez, L.Khettabi, M.Saidi, N.Berthet, M.Maresca, C.Philouze, W.Rachidi, M.Reglier, A.Du Moullinet D'hardemare, H.Jamet. Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons From Experimental and Theoretical Studies. Chembiochem 00235 2024.
ISSN: ESSN 1439-7633
PubMed: 38642076
DOI: 10.1002/CBIC.202400235
Page generated: Thu Oct 31 15:28:56 2024

Last articles

Zn in 9FD2
Zn in 9GUW
Zn in 9GUX
Zn in 9F7C
Zn in 9GUR
Zn in 9F7A
Zn in 9DDE
Zn in 9DBY
Zn in 9EBZ
Zn in 9DGG
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy