Zinc in PDB 9ey5: Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
Protein crystallography data
The structure of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine, PDB code: 9ey5
was solved by
Y.M.Ng,
M.Soler-Lopez,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
48.33 /
2.61
|
Space group
|
P 32 2 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
103.152,
103.152,
138.509,
90,
90,
120
|
R / Rfree (%)
|
19.6 /
23.8
|
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
(pdb code 9ey5). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the
Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine, PDB code: 9ey5:
Jump to Zinc binding site number:
1;
2;
3;
4;
Zinc binding site 1 out
of 4 in 9ey5
Go back to
Zinc Binding Sites List in 9ey5
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn506
b:47.8
occ:1.00
|
O
|
A:HOH625
|
2.0
|
48.8
|
1.0
|
NE2
|
A:HIS224
|
2.2
|
48.5
|
1.0
|
NE2
|
A:HIS192
|
2.2
|
45.6
|
1.0
|
NE2
|
A:HIS215
|
2.2
|
50.5
|
1.0
|
CE1
|
A:HIS224
|
3.0
|
49.7
|
1.0
|
CD2
|
A:HIS215
|
3.1
|
47.7
|
1.0
|
CD2
|
A:HIS192
|
3.2
|
50.2
|
1.0
|
CE1
|
A:HIS192
|
3.2
|
55.4
|
1.0
|
CE1
|
A:HIS215
|
3.3
|
51.0
|
1.0
|
CD2
|
A:HIS224
|
3.3
|
52.4
|
1.0
|
ZN
|
A:ZN507
|
3.5
|
48.8
|
1.0
|
CZ
|
A:PHE400
|
3.9
|
49.4
|
1.0
|
OH
|
A:OTY502
|
3.9
|
62.7
|
1.0
|
CE2
|
A:PHE400
|
4.0
|
51.4
|
1.0
|
ND1
|
A:HIS224
|
4.2
|
51.0
|
1.0
|
NE2
|
A:HIS404
|
4.3
|
48.8
|
1.0
|
CG
|
A:HIS215
|
4.3
|
52.0
|
1.0
|
ND1
|
A:HIS192
|
4.3
|
59.8
|
1.0
|
CG
|
A:HIS192
|
4.3
|
50.3
|
1.0
|
ND1
|
A:HIS215
|
4.3
|
50.9
|
1.0
|
CG
|
A:HIS224
|
4.4
|
50.8
|
1.0
|
CE1
|
A:HIS404
|
4.4
|
46.2
|
1.0
|
CE2
|
A:OTY502
|
4.4
|
65.8
|
1.0
|
CZ
|
A:OTY502
|
4.6
|
70.0
|
1.0
|
CE1
|
A:PHE220
|
4.8
|
48.4
|
1.0
|
NE2
|
A:HIS377
|
4.9
|
45.8
|
1.0
|
|
Zinc binding site 2 out
of 4 in 9ey5
Go back to
Zinc Binding Sites List in 9ey5
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn507
b:48.8
occ:1.00
|
O
|
A:HOH625
|
1.9
|
48.8
|
1.0
|
NE2
|
A:HIS377
|
2.2
|
45.8
|
1.0
|
NE2
|
A:HIS404
|
2.2
|
48.8
|
1.0
|
NE2
|
A:HIS381
|
2.2
|
55.6
|
1.0
|
CE1
|
A:HIS404
|
2.7
|
46.2
|
1.0
|
CD2
|
A:HIS377
|
3.0
|
45.6
|
1.0
|
CE1
|
A:HIS381
|
3.1
|
52.0
|
1.0
|
CD2
|
A:HIS381
|
3.2
|
53.3
|
1.0
|
CE1
|
A:HIS377
|
3.3
|
46.3
|
1.0
|
CD2
|
A:HIS404
|
3.5
|
47.0
|
1.0
|
ZN
|
A:ZN506
|
3.5
|
47.8
|
1.0
|
CE2
|
A:OTY502
|
3.9
|
65.8
|
1.0
|
ND1
|
A:HIS404
|
4.0
|
46.4
|
1.0
|
CE2
|
A:PHE400
|
4.0
|
51.4
|
1.0
|
OH
|
A:OTY502
|
4.1
|
62.7
|
1.0
|
ND1
|
A:HIS381
|
4.1
|
57.8
|
1.0
|
CG
|
A:HIS377
|
4.2
|
46.9
|
1.0
|
CZ
|
A:OTY502
|
4.2
|
70.0
|
1.0
|
CG
|
A:HIS381
|
4.2
|
59.3
|
1.0
|
NE2
|
A:HIS224
|
4.2
|
48.5
|
1.0
|
ND1
|
A:HIS377
|
4.3
|
49.9
|
1.0
|
CZ
|
A:PHE400
|
4.3
|
49.4
|
1.0
|
CG
|
A:HIS404
|
4.4
|
48.9
|
1.0
|
CD2
|
A:LEU403
|
4.5
|
45.5
|
1.0
|
CE1
|
A:PHE220
|
4.6
|
48.4
|
1.0
|
CD2
|
A:HIS224
|
4.6
|
52.4
|
1.0
|
CD2
|
A:OTY502
|
4.7
|
80.0
|
1.0
|
CD2
|
A:PHE400
|
4.8
|
53.9
|
1.0
|
CZ
|
A:PHE220
|
4.9
|
43.7
|
1.0
|
CE1
|
A:HIS224
|
4.9
|
49.7
|
1.0
|
|
Zinc binding site 3 out
of 4 in 9ey5
Go back to
Zinc Binding Sites List in 9ey5
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn508
b:54.9
occ:1.00
|
OE2
|
A:GLU66
|
2.0
|
57.5
|
1.0
|
ND1
|
A:HIS100
|
2.3
|
60.6
|
1.0
|
O
|
A:HOH629
|
2.4
|
55.2
|
1.0
|
O
|
A:HOH616
|
2.4
|
59.7
|
1.0
|
CE1
|
A:HIS100
|
3.1
|
59.9
|
1.0
|
CG
|
A:HIS100
|
3.2
|
57.6
|
1.0
|
CD
|
A:GLU66
|
3.2
|
61.1
|
1.0
|
CB
|
A:HIS100
|
3.6
|
56.5
|
1.0
|
OE1
|
A:GLU66
|
3.9
|
64.6
|
1.0
|
NH1
|
A:ARG64
|
4.1
|
55.3
|
1.0
|
OD1
|
A:ASN102
|
4.2
|
58.3
|
1.0
|
NE2
|
A:HIS100
|
4.2
|
67.3
|
1.0
|
O
|
A:HIS100
|
4.2
|
52.4
|
1.0
|
CG
|
A:GLU66
|
4.3
|
56.6
|
1.0
|
CD2
|
A:HIS100
|
4.3
|
59.0
|
1.0
|
CD
|
A:ARG64
|
4.5
|
50.2
|
1.0
|
C
|
A:HIS100
|
4.5
|
55.0
|
1.0
|
CB
|
A:ARG64
|
4.6
|
56.1
|
1.0
|
CA
|
A:HIS100
|
4.7
|
54.6
|
1.0
|
CG
|
A:ARG64
|
4.8
|
53.4
|
1.0
|
O
|
A:CYS101
|
5.0
|
58.7
|
1.0
|
|
Zinc binding site 4 out
of 4 in 9ey5
Go back to
Zinc Binding Sites List in 9ey5
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure of Human Tyrosinase-Related Protein 1 (TYRP1) in Complex with (S)-2,4-Dihydroxyphenylalanine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn509
b:69.8
occ:1.00
|
OE2
|
A:GLU88
|
2.1
|
72.5
|
1.0
|
NE2
|
A:HIS81
|
2.2
|
88.3
|
1.0
|
NE2
|
A:HIS75
|
2.2
|
69.4
|
1.0
|
CE1
|
A:HIS81
|
2.7
|
87.7
|
1.0
|
CD
|
A:GLU88
|
2.8
|
67.1
|
1.0
|
OE1
|
A:GLU88
|
2.8
|
66.0
|
1.0
|
CE1
|
A:HIS75
|
3.0
|
73.1
|
1.0
|
CD2
|
A:HIS81
|
3.3
|
93.8
|
1.0
|
CD2
|
A:HIS75
|
3.3
|
71.1
|
1.0
|
ND1
|
A:HIS81
|
3.9
|
90.7
|
1.0
|
CG
|
A:HIS81
|
4.2
|
97.3
|
1.0
|
ND1
|
A:HIS75
|
4.2
|
73.3
|
1.0
|
CG
|
A:GLU88
|
4.2
|
60.9
|
1.0
|
CG
|
A:HIS75
|
4.4
|
73.0
|
1.0
|
CD1
|
A:ILE432
|
4.5
|
57.0
|
1.0
|
CA
|
A:GLY83
|
4.6
|
87.2
|
1.0
|
|
Reference:
C.Faure,
Y.M.Ng,
C.Belle,
M.Soler-Lopez,
L.Khettabi,
M.Saidi,
N.Berthet,
M.Maresca,
C.Philouze,
W.Rachidi,
M.Reglier,
A.Du Moullinet D'hardemare,
H.Jamet.
Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons From Experimental and Theoretical Studies. Chembiochem 00235 2024.
ISSN: ESSN 1439-7633
PubMed: 38642076
DOI: 10.1002/CBIC.202400235
Page generated: Thu Oct 31 15:29:01 2024
|