Zinc in PDB 9cbt: Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10

The structure of Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10, PDB code: 9cbt was solved by M.K.Fenwick, H.J.Young, H.Lin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.43 / 1.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.433, 63.193, 114.608, 90, 90.79, 90
R / Rfree (%)	19.8 / 23.9

The binding sites of Zinc atom in the Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10 (pdb code 9cbt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10, PDB code: 9cbt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:36.9 occ:1.00 SG A:CYS259 2.3 34.9 1.0 SG A:CYS283 2.3 36.0 1.0 SG A:CYS256 2.3 34.6 1.0 SG A:CYS280 2.3 36.3 1.0 CB A:CYS280 3.0 36.8 1.0 CB A:CYS256 3.2 36.2 1.0 CB A:CYS259 3.2 33.1 1.0 CB A:CYS283 3.6 34.2 1.0 N A:CYS259 3.7 28.5 1.0 CA A:CYS259 4.0 31.7 1.0 N A:CYS283 4.1 35.5 1.0 CA A:CYS283 4.3 32.0 1.0 N A:GLY285 4.4 35.3 1.0 CA A:CYS280 4.5 36.8 1.0 CB A:VAL258 4.7 37.5 1.0 CA A:CYS256 4.7 34.8 1.0 CA A:GLY285 4.7 37.2 1.0 C A:CYS283 4.7 35.4 1.0 C A:CYS259 4.8 35.5 1.0 NH1 A:ARG261 4.8 41.7 1.0 C A:VAL258 4.8 40.2 1.0 N A:THR284 4.9 39.1 1.0 CB A:ARG261 5.0 40.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:46.0 occ:1.00 SG B:CYS283 2.3 44.2 1.0 SG B:CYS256 2.3 44.5 1.0 SG B:CYS259 2.3 45.5 1.0 SG B:CYS280 2.3 44.3 1.0 CB B:CYS280 3.0 45.4 1.0 CB B:CYS259 3.2 42.5 1.0 CB B:CYS256 3.3 39.8 1.0 CB B:CYS283 3.3 46.0 1.0 N B:CYS259 3.7 40.5 1.0 N B:CYS283 3.9 46.6 1.0 CA B:CYS259 4.0 41.1 1.0 CA B:CYS283 4.1 48.7 1.0 CA B:CYS280 4.5 46.1 1.0 N B:GLY285 4.6 47.3 1.0 CB B:VAL258 4.6 45.0 1.0 C B:CYS283 4.6 49.5 1.0 CA B:CYS256 4.8 38.1 1.0 NH1 B:ARG261 4.8 48.5 1.0 C B:CYS259 4.8 39.1 1.0 N B:THR284 4.8 58.9 1.0 C B:VAL258 4.8 47.4 1.0 CA B:GLY285 4.9 45.8 1.0 CB B:ARG261 5.0 43.4 1.0 CB B:VAL282 5.0 54.4 1.0 CD B:ARG261 5.0 47.8 1.0

M.K.Fenwick, J.H.Young, H.Lin. Crystal Structure of Human Sirtuin 3 Fragment (Residues 118-399) Bound to Intermediates From Reaction with Nad and Inhibitor NH6-10 To Be Published.