Zinc in PDB 8wpn: Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs

The structure of Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Zinc atom in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs (pdb code 8wpn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs, PDB code: 8wpn:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:151.8 occ:1.00 ND1 A:HIS172 2.1 95.0 1.0 SG A:CYS176 2.3 112.7 1.0 SG A:CYS178 2.3 126.2 1.0 SG A:CYS181 2.3 113.8 1.0 CB A:CYS178 2.3 122.0 1.0 CE1 A:HIS172 2.5 93.0 1.0 CG A:HIS172 3.0 91.2 1.0 NE2 A:HIS172 3.5 90.8 1.0 CA A:CYS178 3.6 122.3 1.0 CD2 A:HIS172 3.7 89.7 1.0 CB A:HIS172 3.7 88.0 1.0 N A:CYS178 3.7 122.2 1.0 CB A:CYS176 4.0 111.2 1.0 CB A:CYS181 4.0 112.9 1.0 C A:CYS178 4.7 122.7 1.0 CA A:HIS172 4.9 85.8 1.0 N A:ASN177 5.0 124.3 1.0 N A:CYS181 5.0 114.4 1.0 C A:ASN177 5.0 123.6 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:151.8 occ:1.00 ND1 B:HIS172 2.1 95.0 1.0 SG B:CYS176 2.3 112.7 1.0 SG B:CYS178 2.3 126.2 1.0 SG B:CYS181 2.3 113.8 1.0 CB B:CYS178 2.3 122.0 1.0 CE1 B:HIS172 2.5 93.0 1.0 CG B:HIS172 3.0 91.2 1.0 NE2 B:HIS172 3.5 90.8 1.0 CA B:CYS178 3.6 122.3 1.0 CD2 B:HIS172 3.7 89.7 1.0 CB B:HIS172 3.7 88.0 1.0 N B:CYS178 3.7 122.2 1.0 CB B:CYS176 4.0 111.2 1.0 CB B:CYS181 4.0 112.9 1.0 C B:CYS178 4.7 122.7 1.0 CA B:HIS172 4.9 85.8 1.0 N B:ASN177 5.0 124.3 1.0 N B:CYS181 5.0 114.4 1.0 C B:ASN177 5.0 123.6 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1002 b:151.8 occ:1.00 ND1 C:HIS172 2.1 95.0 1.0 SG C:CYS176 2.3 112.7 1.0 SG C:CYS178 2.3 126.2 1.0 SG C:CYS181 2.3 113.8 1.0 CB C:CYS178 2.3 122.0 1.0 CE1 C:HIS172 2.5 93.0 1.0 CG C:HIS172 3.0 91.2 1.0 NE2 C:HIS172 3.5 90.8 1.0 CA C:CYS178 3.6 122.3 1.0 CD2 C:HIS172 3.7 89.7 1.0 CB C:HIS172 3.7 88.0 1.0 N C:CYS178 3.7 122.2 1.0 CB C:CYS176 4.0 111.2 1.0 CB C:CYS181 4.0 112.9 1.0 C C:CYS178 4.7 122.7 1.0 CA C:HIS172 4.9 85.8 1.0 N C:ASN177 5.0 124.3 1.0 N C:CYS181 5.0 114.4 1.0 C C:ASN177 5.0 123.6 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of the Human TRPC4 in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1003 b:151.8 occ:1.00 ND1 D:HIS172 2.1 95.0 1.0 SG D:CYS176 2.3 112.7 1.0 SG D:CYS178 2.3 126.2 1.0 SG D:CYS181 2.3 113.8 1.0 CB D:CYS178 2.3 122.0 1.0 CE1 D:HIS172 2.5 93.0 1.0 CG D:HIS172 3.0 91.2 1.0 NE2 D:HIS172 3.5 90.8 1.0 CA D:CYS178 3.6 122.3 1.0 CD2 D:HIS172 3.7 89.7 1.0 CB D:HIS172 3.7 88.0 1.0 N D:CYS178 3.7 122.2 1.0 CB D:CYS176 4.0 111.2 1.0 CB D:CYS181 4.0 112.9 1.0 C D:CYS178 4.7 122.7 1.0 CA D:HIS172 4.9 85.8 1.0 N D:ASN177 5.0 124.3 1.0 N D:CYS181 5.0 114.4 1.0 C D:ASN177 5.0 123.6 1.0

J.Won, H.Jeong, H.H.Lee. Structure of A Trp Channel To Be Published.